Quinoline compounds, synthesizing method, applications in synthesis of alkaloid of camptothecins
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
- Publication Date
- 2009-01-07
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] This patent relates to the field of organic synthesis. More specifically, it relates to a class of quinoline compounds that are intermediates for the synthesis of camptothecin alkaloids. Differently substituted quinoline compounds can be synthesized from simple and easy-to-obtain raw materials and used as synthetic intermediates It is used in the synthesis of camptothecin alkaloid drugs. Background technique
[0002] Quinolines are a major class of heterocyclic compounds, and many methods for their preparation have been developed since the late 19th century. Among them, the skeleton quinoline ring is commonly found in some natural products, drugs, and functional materials, especially in alkaloids. Therefore, the construction method of the quinoline ring is of great significance for the synthesis and design of many active molecules.
[0003] A variety of natural products contain quinoline structures, and camptothecin alkaloids are one of them. Campto...