Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel quinuclidine derivatives and their use

A technology for quinucidine and derivatives, applied in the field of new quinucidine derivatives and their uses, capable of solving problems such as no reports on the effects of nicotine and/or monoamine receptors

Inactive Publication Date: 2005-09-28
NEUROSEARCH AS
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No effects on nicotinic and / or monoamine receptors reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel quinuclidine derivatives and their use
  • Novel quinuclidine derivatives and their use
  • Novel quinuclidine derivatives and their use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0188] The present invention is further described in detail with reference to the following examples, which are not intended to limit the scope of the invention claimed in the claims in any way.

[0189] General Notes: All reactions involving air-sensitive reagents or intermediates were performed under nitrogen with anhydrous reagents. Magnesium sulfate was used as a drying agent in the work-up procedure, and the solvent was evaporated under reduced pressure.

[0190] Method A

[0191] (±)-3-(Naphthalen-2-yloxy)-1-aza-bicyclo[2.2.2]octane fumarate

[0192] (Compound A1)

[0193] To 2-naphthol (5.0 g, 34.5 mmol), (±)-3-quinuclidinol (guinuclidinol) (2.94 g, 23.1 mmol), triphenylphosphine (9.0 g, 34.5 mmol) and THF (100 mL) was added to the mixture: diethyl azodicarboxylate (5.4 mL, 34.5 mmol) was added over 30 minutes at room temperature. The reaction mixture was stirred at 50 °C for 20 hours. Aqueous sodium hydroxide solution (100 mL, 1M) was added. The mixture w...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Description

technical field [0001] The present invention relates to novel quinucidine derivatives and their use as medicines. Due to their pharmaceutical properties, the compounds of the present invention can be used in the treatment of diseases or conditions associated with the cholinergic system of the central nervous system (CNS), peripheral nervous system (PNS), diseases or conditions associated with smooth muscle contraction, endocrine diseases or conditions, diseases or conditions associated with neurodegeneration, diseases or conditions associated with inflammation, pain, and withdrawal symptoms associated with cessation of chemical substance abuse. technical background [0002] The endogenous cholinergic neurotransmitter acetylcholine expresses its biological effects through two types of cholinergic receptors, the muscarinic acetylcholine receptors (mAChR) and the nicotinic acetylcholine receptors (nAChR). [0003] It is well established that muscarinic acetylcholine receptors ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/439A61K31/444A61K31/4709A61K31/498A61K31/501A61P1/14A61P3/00A61P3/04A61P5/14A61P5/24A61P9/06A61P9/10A61P9/12A61P11/06A61P15/06A61P15/08A61P15/10A61P17/00A61P21/00A61P21/04A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28C07D453/02
CPCC07D453/02A61P1/14A61P11/06A61P15/06A61P15/08A61P15/10A61P17/00A61P21/00A61P21/04A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P3/00A61P3/04A61P5/14A61P5/24A61P9/06A61P9/10A61P9/12
Inventor D·皮特斯G·M·奥尔森E·O·尼尔森P·K·阿林格T·D·乔根森
Owner NEUROSEARCH AS
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com