107 results about "Adamantane derivatives" patented technology

The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I (which are quinuclidine derivatives), formula II (which are norbornane derivatives), formula III (which are adamantane derivatives), and formula IV (which are phenothiazine derivatives): wherein R1, R2 and R3 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy, halogeno, amino, phenyl, or R4NR5; R4 and R5 are each independently hydrogen, or (CH2)n-[NH(CH2)x]y-NHR6, or (CH2)n-[NH(CH2)x]y-NH-NHR6, or (CH2)n-[NH(CH2)x]y-(NR7=)CNHR6, or (CH2)n-[NH(CH2)x]y-NH(NR7=)CNHR6 wherein n is from 0-5, y is from 0-5 and each x is independently from 1-5; R6, and R7 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy, or halogeno; and pharmaceutically acceptable salts and optically active isomers thereof.

In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the formula (2):wherein R1 and R2 independently represents a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a cycloalkyl group; or R1 and R2 may bond together to form a double bond or an aromatic or non-aromatic ring; Y is O or OH and n=1 to 3;or the imide compound and a co-catalyst (e.g., a transition metal compound), an adamantane derivative having a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is oxidized with oxygen. According to the above method, an adamantane derivative having a hydroxyl group together with a functional group such as a nitro group, an amino group, a hydroxyl group, a carboxyl group, a hydroxymethyl group and an isocyanato group is efficiently obtained.

The invention relates to a chemical illumination immunity analysis method for checking human cTnT, which uses acridiniumester and/or alkaline phosphatase as label. The immunity reaction uses two-site immunoassay and/or competition law. The immunity reaction can use streptavidin-biotin two-site immunoassay to improve sensitivity. The invention uses NaOH and H2O2 as acridiniumester illumination initiating agent, uses 1, 2-dioxo cyclohexane derivative (adamantine derivative) as the illumination substrate of alkaline phosphatase, and uses fluorescein derivative and surface activator as illumination renforcing agent. The solid carrier is orifice plate, macromolecule polymer tube (ball) and ferriferrous oxide magnetic particles or the like.

The invention discloses star-shaped adamantane derivative molecular glasses having the following structure shown in the description, wherein substituents R1-R12 are respectively hydrogen, hydroxy, alkoxy or acid sensitivity substituents; the substituents R1-R12 can be different or the same, but the substituents at a same benzene ring cannot both be hydrogen. The invention also discloses a preparation method of the star-shaped adamantane derivative molecular glasses. The method is simple in synthesis process, products of the steps of a reaction all can be separated from the system through a recrystallization or precipitation method. The molecular glasses can be used as photoresist main body materials made into thin films, and also can be used for photoetching.

Disclosed herein is an adamantane derivative represented by the following general formula (I):

(wherein R represents a hydrogen atom, a fluorine atom, a methyl group or a trifluoromethyl group; Y represents a hydrogen atom, a hydroxyl group, ═O formed by two Ys together, a carboxyl group, or a hydrocarbon group having 1 to 20 carbon atoms or a cyclic hydrocarbon group having 3 to 20 carbon atoms; m is 13 and n is 3, or m is 12 and n is 4; and p is an integer of one or more), a production method thereof, a resin composition containing the adamantane derivative, and a cured product thereof. The present invention provides a cured product advantageous as various coating agents, a microlens, a film condenser, a colored composition for a liquid crystal color filter, a pattern organizer formed in nanoimprinting, and the like, having transparency, heat resistance, good mechanical properties, low volume shrinkage, and low coefficient of linear expansion, as well as liquid adamantyl group-containing (meth)acrylates to produce the cured product, the production method thereof, and the resin composition.

A homoadamantane derivative represented by the following formula (I): wherein R¹ and R² are independently a hydrogen atom or a linear, branched or cyclic hydrocarbon group having 1 to 6 carbon atoms, x is a hydroxyl group or a halogen atom, and n and m are independently an integer of 0 to 3, provided that n and m are not simultaneously 0.

The present invention is an adamantane derivative which provides optical characteristics such as transparency, (long term) light resistance and the like, long term heat resistance, electric characteristics such as dielectric constant and the like, and good mechanical properties; a production method thereof; and a resin composition containing the above-mentioned adamantane derivative that is an adamantane derivative represented by general formulae (I) to (III); for example, a production method of an adamantane derivative represented by the general formula (III) by reacting an adamantane derivative represented by the general formula (II) with acrylates, a resin composition containing an adamantane derivative represented by the general formula (II) and an epoxy resin curing agent, and a resin composition containing an adamantane derivative represented by the general formula (III) and a thermopolymerization initiator or a photopolymerization initiator.

In the formula, R¹ represents C_nH_2n+1 (n is an integer of 1 to 10); R² represents H, CH₃, F or CF₃; j is an integer of 1 to 4; k is an integer of 0 to 3; m is an integer of 2 to 5; and j+k+m≦6.

The present invention relates to an adamantane derivative compound and an organic light-emitting diode (OLED) including the same, and more particularly, to an adamantane derivative compound capable of being used in an OLED and an OLED having excellent properties such as low voltage and high efficiency using the compound.

The adamantane derivatives of the present invention which are represented by the general formula (1):

wherein X is a hydrogen atom, alkyl, halogen-containing alkyl, halogen, or hydroxyl-, halogen-, nitrile- or ether-containing hydrocarbyl, and a plurality of X groups, if any, may be the same or different from each other; n₁ is an integer of 1 to 14; R₁ to R₄ may be the same or different from each other and are independently alkyl or halogen-containing alkyl; and Y₁ and Y₂ may be the same or different from each other and are independently a hydrogen atom or a group represented by the general formula (2):

wherein R₅ to R₇ may be the same or different from each other and are independently a hydrogen atom, alkyl, halogen or halogen-containing alkyl, are excellent in optical properties, heat resistance and acid-dissociating property, and useful as crosslinking-type resins, optical materials such as optical fibers, light wave guides, optical disk substrates and photoresists as well as raw materials thereof, intermediate products of medicines or agricultural chemicals, and various other industrial products.

To provide a polymerizable group-containing and fluorine-containing adamantane derivative capable of affording a cured product having good heat resistance, good mechanical properties such as mar resistance and a low refractive index, a resin composition containing such a polymerizable group-containing adamantane derivative, and a fluorine-containing adamantane derivative which is useful as a reaction intermediate used for the production of the polymerizable group-containing and fluorine-containing adamantane derivative.

Specifically provided are a fluorine-containing adamantane derivative represented by the general formula (I) below, a polymerizable group-containing and fluorine-containing adamantane derivative represented by the general formula (II) below, and a resin composition containing such a polymerizable group-containing and fluorine-containing adamantane derivative. In the formula, R¹ and R² are each a hydrogen atom, for example, n is an integer of 0 or more, X¹ is a polymerizable group represented by the formula (III-a), for example, Y is a hydrogen atom, for example, s and t are each an integer of 1 to 15, and u is an integer of 0 to 14, with the proviso that s+t+u=16.

The present invention provides novel compounds which are useful for the production of fluorinated adamantane derivatives excellent in etching resistance and useful as photolithographic material and so on. Namely, the present invention provides compounds represented by the following formulae (3) and (4):

A(-G-Q-R)_n  (3)

A^f(-G^f-Q-R^f)_n  (4)

provided that the symbols in the formula have the following meanings: A: a n-valent group having n hydrogen atoms of adamantane converted to connecting bonds, wherein hydrogen atoms not converted to connecting bonds, may be each substituted by an alkyl group, R: a fluorinated monovalent organic group, n: an integer of from 1 to 4,

• • G: —CH₂— or a single bond, Q: —COO— or —OCO—,
  • A^f: a n-valent group (A) having n hydrogen atoms bonded to carbon atoms of adamantane converted to connecting bonds, wherein hydrogen atoms not converted to connecting bonds, may be each substituted by an alkyl group, in which at least one of hydrogen atoms forming C—H bonds is substituted by a fluorine atom,
  • R^f: a fluorinated monovalent organic group,
  • G^f: —CF₂— or a single bond.

This invention provides an adamantane derivative that can provide a cured product having excellent optical properties such as transparency and lightfastness, long-term heat resistance, and electric characteristics such as permittivity, and an epoxy resin having an adamantane skeleton, a resin composition comprising them, and an optical electronic member using the resin composition. The adamantane derivative is represented by general formula (I). The epoxy resin having an adamantane skeleton is represented by general formula (V) or (VI). The resin composition comprises them. The optical electronic member uses the resin composition. In the formula, W represents, for example, a hydrogen atom, X represents a group represented by general formula (II), Y represents, for example, —O—, Z represents a group represented by formula (III) or (IV), R¹ represents a methyl or ethyl group, R² represents an alkyl group having 1 to 4 carbon atoms, k is an integer of 0 to 10, m is an integer of 0 to 14, n is an integer of 2 to 16, m+n=16, and p and q are an integer of 0 to 5.

The invention relates to adamantane diaza-crown ether derivatives and the use of mono and diaza-crown ether adamantine derivatives in treatment, especially in tumor treatment. Adamantane aza-crown ethers were obtained by reaction of the corresponding adamantane derived tosylates or adamantane acid chlorides with mono- and diaza-18-crown-6. The prepared compounds showed moderate (monoaza-18-crown-6) to strong (diaza-18-crown-6) antiproliferative and cytotoxic activity on several tumor cell lines, revealing their potential for inhibiting the growth of other tumor cells.

The invention discloses a medicine tromantadine with an adamantane structure, and adamantane derivates and analogs of the tromantadine, wherein the tromantadine and the adamantane derivates and analogs of the tromantadine have new activity and new indications. The invention further relates to the application of the compounds serving as anti-tumor medicines. The medicine tromantadine has a structure as shown in the specification; and the derivates and analogs generated through the structure, various compounds having the same/or the different structure as the mother nucleus structure of the compound or having similarity or correlation with the compound in the aspect of bioactivity, inorganic acid salts, organic acid salts, inorganic alkali salts, organic alkali salts or compound salts of the adamantane derivates and analogs and prodrugs of inorganic acid salts, organic acid salts, inorganic alkali salts, organic alkali salts or compound salts, are included. The derivates and analogs have the anti-tumor pharmacological activity and are applied as antitumor medicines and used in combination with other know anti-tumor medicines. The derivates and analogs are accompanied with the tumor treatment application when used in the treatment of tumor related diseases or other diseases, the application includes the treatment of diseases caused by virus, bacteria and fungi, nerve system diseases, endocrine system diseases, immune system diseases and the like, and the derivates and analogs are matched with other medicines for application.

Disclosed are glass photoresists generated from adamantane derivatives containing acetal and/or ester moieties as novel high-performance photoresist materials. Some of the disclosed adamantane-based glass resists have a tripodal structure and other disclosed adamantane-based glass resists include one or more cholic groups. The disclosed adamantane derivatives can be synthesized from starting materials which are commercially available. By way of example only, one of many disclosed amorphous glass photoresists has the following structure:

The invention provides an adamantane based resin composite and a preparation method thereof. The adamantane based resin composite comprises an adamantane based resin monomer and a curing agent glycidyl methacrylate, wherein the adamantane based resin monomer is an adamantane derivative with a tannin skeleton, and provided with phthalic anhydride and derivative groups thereof. A prepared resin has the advantages of stable structure, high temperature resistance, low shrinkage rate, good biological activity, and the like; and in the manufacturing method of the resin, reaction conditions are mild, and reactions are implemented simply and easily.

To provide an adamantane derivative, a compound having an adamantane skeleton, compositions containing them that can provide a cured product having excellent optical properties such as transparency and light resistance, long-term heat resistance and electric characteristics such as dielectric permittivity, and optical electronic members using the compositions.

An adamantane derivative represented by the general formula (I), a compound with an adamantane skeleton represented by the general formula (VII) or (VIII), compositions containing them, and optical electronic members using the resin compositions. In the formulas, W represents, for example, a hydrogen atom, X represents, for example, a group represented by the general formula (II), Y represents a group represented by the formula (V) or (VI), R¹ represents a methyl group or an ethyl group, R² represents a C₁ to C₁₀ hydrocarbon group which may contain O or S, m is an integer of 2 to 4, k is an integer of 0 to (16−m) and p and q are each an integer of 1 to 5.

A photoresist is formed on an object layer of a semiconductor device by coating the object layer with a photoresist composition including about 7 percent to about 14 percent by weight of an inclusion complex having a β-cyclodextrin derivative as a host and an adamantane derivative as a guest, about 0.1 percent to about 0.5 percent by weight of a photoacid generator, and a remainder of an organic solvent.

The invention relates to a process for the preparation of 3-hydroxyadamantaneglyoxylic acid of the general formula (1)

or a derivative or salt thereof. In the process, an 1-acyl derivative of adamantane having the formula (2):

wherein R is a C₁-C₅ hydrocarbyl; CH₂OH; CHO; COOH, is contacted with an oxidant under oxidizing conditions leading to the 3-hydroxyadamantaneglyoxylic acid (1) or the derivative or salt thereof.

The invention aims to provide an adamantane derivative, its preparation method and an application of a derivative containing the adamantane structure in epoxy resin. the invention mainly includes an application of the above adamantane derivative in curing epoxy resin and raising properties of epoxy resin, such as moisture and heat resistance, dielectric property, weatherability, heat stability, oxidation resistance, organic solvent corrosion resistance and the like, such that the adamantane derivative has a wide range of application. Through repeated researches, the inventor finds out that the derivative containing the adamantane structure can remarkably enhance properties of epoxy resin, such as moisture and heat resistance, dielectric property, heat stability, ageing resistance and the like, when used as a curing agent to be connected to epoxy resin.