Pharmaceutical composition containing (3S, 2'R)-3-(2'-hydroxy-2'-cyclopentyl-2'-phenylethoxy) quinuclidine hydrochloride and uses thereof
A technology of phenylethoxy and quinuclidine, which can be used in drug combinations, inactive components of polymer compounds, cardiovascular system diseases, etc., can solve the problems of different enantiomeric activities, unreported, low activity, etc. , to achieve the effect of strong stereoselectivity, avoiding toxic and side effects, and high optical purity
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Embodiment 1
[0054] An injection preparation containing (3S, 2'R)-3-(2'-hydroxyl 2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride, characterized in that the composition And the weight ratio is:
[0055] Recipe (1)
[0056] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 0.1g
[0057] Purified water: 1L
[0058] Hydrochloric acid (3mol / L): 10ml
[0059] Prepared into 1000 tubes, unit concentration 0.1mg / ml.
[0060] Recipe (2)
[0061] (3S,2'R)-3-(2'-Hydroxy 2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 1g
[0062] Purified water: 1L
[0063] Hydrochloric acid (3mol / L): 10ml
[0064] Prepared into 1000 tubes, unit concentration 1mg / ml.
[0065] Recipe (3)
[0066] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 10g
[0067] Purified water: 1L
[0068] Hydrochloric acid (3mol / L): 10ml
[0069] Prepare 1000 vials with a unit concentration of 10mg / ml.
[0070] It is used for the treatment of ch...
Embodiment 2
[0072] A tablet containing (3S, 2'R)-3-(2'-hydroxyl-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride, characterized in that the composition The ingredients and weight ratio are:
[0073] Recipe (4)
[0074] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 0.1g
[0075] Lactose: 68g
[0076] Sodium carboxymethyl starch: 10g
[0077] Magnesium stearate: 0.35g
[0078] Prepared into 1000 tablets, unit content 0.1mg / tablet, orally, 1 tablet each time, once a day.
[0079] Recipe (5)
[0080] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 1g
[0081] Lactose: 68g
[0082] Sodium carboxymethyl starch: 10g
[0083] Magnesium stearate: 0.35g
[0084] Prepared into 1000 tablets, unit content 1mg / tablet, orally, 1 tablet each time, once a day.
[0085] Recipe (6)
[0086] (3S,2'R)-3-(2'-Hydroxy 2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 0.1g
[0087] Lactose: 520g
[0088] Sodium ca...
Embodiment 3
[0099] An aerosol and spray containing (3S, 2'R)-3-(2'-hydroxyl-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride, It is characterized in that the composition and weight ratio are:
[0100] Recipe (eight)
[0101] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 10g
[0102] Absolute ethanol: 1000ml
[0103] HFC-134a: 11.2kg
[0104] Prepare 1000 vials, unit concentration 10mg / bottle.
[0105] For the treatment of chronic obstructive pulmonary disease, various shock diseases.
[0106] Recipe (9)
[0107] (3S,2'R)-3-(2'-Hydroxy-2'-cyclopentyl-2'-phenylethoxy)quinuclidine hydrochloride: 10g
[0108] Purified water: 1000ml
[0109] Prepare 1000 vials, unit concentration 10mg / bottle.
[0110] For the treatment of chronic obstructive pulmonary disease, various shock diseases.
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