84 results about "Phenothiazine derivative" patented technology

The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I (which are quinuclidine derivatives), formula II (which are norbornane derivatives), formula III (which are adamantane derivatives), and formula IV (which are phenothiazine derivatives): wherein R1, R2 and R3 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy, halogeno, amino, phenyl, or R4NR5; R4 and R5 are each independently hydrogen, or (CH2)n-[NH(CH2)x]y-NHR6, or (CH2)n-[NH(CH2)x]y-NH-NHR6, or (CH2)n-[NH(CH2)x]y-(NR7=)CNHR6, or (CH2)n-[NH(CH2)x]y-NH(NR7=)CNHR6 wherein n is from 0-5, y is from 0-5 and each x is independently from 1-5; R6, and R7 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy, or halogeno; and pharmaceutically acceptable salts and optically active isomers thereof.

A non-aqueous redox flow battery includes a negative electrode immersed in a first non-aqueous liquid electrolyte solution, a positive electrode immersed in a second non-aqueous liquid electrolyte solution, and a semi-permeable separator interposed between the negative and positive electrodes, wherein the second the non-aqueous liquid electrolyte solution comprises a compound of the formula:

The invention provides a composition and a method of using the composition for inhibiting the unwanted polymerization of ethylenically unsaturated monomers. The composition is prepared by reducing a nitroxide stable free radical to its corresponding hydroxylamine through reaction with a dialkyl / aryl hydroxylamine and subsequent addition of a polymerization prevention component selected from phenolic antioxidants, phenylenediamine and phenylenediamine derivatives, or phenothiazine and phenothiazine derivatives targeted towards ethylenically unsaturated monomers. The conversion of the nitroxide by the dialkyl / aryl hydroxylamine is to prevent it or the polymerization prevention component from being “spent” by reaction with each other, impurities or any other incompatible components. This allows previously incompatible combinations to now work effectively. In fact, the combination is more efficacious as the combination exerts a synergy due to the presence of various polymerization prevention reagents. The composition is a synergistic combination of various polymerization inhibition compounds for the inhibition of the unwanted polymerization of ethylenically unsaturated monomers.

The invention provides a fluorescent probe. The structural formula of the fluorescent probe is represented by general formula I shown in the specification, wherein R is one of C7-C12 alkyl groups. The invention further provides a preparation method of the fluorescent probe and an application of the fluorescent probe to detection of cyanide ions. A phenothiazine derivative is used as a fluorescent parent, a malononitrile structure is introduced as an active center reacting with the cyanide ions, and selective detection of the cyanide ions is realized by the aid of fluorescent differences between reactants and products. The prepared fluorescent probe PTZ is excited at 488 nm and emitted at 702 nm, has very high selectivity and sensitivity for the cyanide ions and is high in response speed, the lowest concentration of the cyanide ions is detected to be 67 nmol / L<-1>, the cyanide ions can be detected quantitatively, and the fluorescent probe can be applied to detection of the cyanide ions in water bodies, soil and organisms.

Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.

The invention discloses phenothiazine derivative fluorescence carbon dots as well as a preparation method and application thereof. The preparation method comprises a step of hydrothermal synthesis reaction, reaction raw materials are prepared from a phenothiazine derivative and a passivating agent; the phenothiazine derivative has a structure shown in a general formula I. The method has the advantages of simple, economic, green and environment-friendly synthesis process; the prepared phenothiazine derivative fluorescence carbon dots have the advantages of uniform particle size and stable structure, and have obvious adsorption and fluorescence emission in the visible light and near-infrared areas. The carbon dots can be used for cell fluorescence imaging, and singlet oxygen can be producedunder light irradiation of visible light and near-infrared wavelength and the carbon dots can be used for killing tumor cells, and the carbon dots are desired photosensitizers for photodynamic therapy. The formula (1) is shown in the description.

The invention provides a composition and a method of using the composition for inhibiting the unwanted polymerization of ethylenically unsaturated monomers. The composition is prepared by reducing a nitroxide stable free radical to its corresponding hydroxylamine through reaction with a dialkyl / aryl hydroxylamine and subsequent addition of a polymerization prevention component selected from phenolic antioxidants, phenylenediamine and phenylenediamine derivatives, or phenothiazine and phenothiazine derivatives targeted towards ethylenically unsaturated monomers. The conversion of the nitroxide by the dialkyl / aryl hydroxylamine is to prevent it or the polymerization prevention component from being “spent”by reaction with each other, impurities or any other incompatible components. This allows previously incompatible combinations to now work effectively. In fact, the combination is more efficacious as the combination exerts a synergy due to the presence of various polymerization prevention reagents. The composition is a synergistic combination of various polymerization inhibition compounds for the inhibition of the unwanted polymerization of ethylenically unsaturated monomers.

Belonging to the field of organic optoelectronic materials and organic photoelectric conversion application, the invention provides a phenothiazine pure organic dye, a preparation method and application thereof in dye-sensitized solar cells. The phenothiazine pure organic dye has a phenothiazine group, different functional groups are introduced to the N position of the phenothiazine group, and the phenothiazine group is connected to a carbazole group through meta-benzene, and the phenothiazine pure organic dye has a general formula shown as the specification, The dye provided by the invention can be applied to dye-sensitized solar cell devices to achieve high photoelectric conversion efficiency. The synthesis and preparation method involved in the invention is simple and controllable, and is low in cost, and the cell devices thereof have high efficiency. The phenothiazine pure organic dye is expected to replace traditional heavy metal sensitizing agent dyes, and has the application prospect of commercial production.

The invention belongs to the technical field of intelligent materials, and discloses a multi-stimulus-response organic small-molecular luminescent material, and preparation and application thereof. By utilizing the dual-fluorescence characteristics of phenothiazine derivatives, a series of luminescent materials are designed and synthesized; and external stimulus effects are utilized to regulate the reciprocal transformation of two conformations, thereby providing a simple feasible effective design strategy for the stimulus-response luminescent material. According to the preparation method, phenothiazine, which is used as a main reaction raw material, is subjected to a series of simple reactions to obtain various target products. The obtained product has the advantages of definite molecular weight, single structure, lower glass transition temperature and greatly higher stimulus-response sensitivity. The stimulus-response principle of the material is conversion between two different conformations instead of the influence of the intermolecular acting force and accumulation mode, so that the material has the multi-stimulus-response characteristic, and is applicable to sensors of force, temperature, pH and the like.

The preset invention relates to use of antipsychotic phenothiazine derivative for eliminating cancer stem cells (CSCs) and / or preventing a cancer. The invention also provides a pharmaceutical composition for treating a cancer, and / or preventing or delaying cancer recurrence comprising trifluoperazine and an anti-cancer drug, such as gefitinib or cisplatin.

The invention provides a method for copper catalytic synthesis phenothiazine compound, which is wide in scope of application, excellent in regioselectivity and free of ligand. Ortho-amino aromatic thiophenol and ortho-binary aryl halide are reacted to obtain phenothiazine derivative in inert atmosphere with existence of the copper salt catalytic agent and alkali. Raw materials of the method are easy to obtain, the cost is low, the process is environment-friendly, the great majority of the phenothiazine derivatives are high in synthetic productivity, and the method has industrial application prospects.

The present invention provides a phenothiazine-derivative color-measuring method that can detect a phenothiazine-derivative color even at a wavelength longer than the wavelength that exhibits maximum absorption. A phenothiazine-derivative color is detected, by adding a 5-hydroxy-1-(4-sulfophenyl)-4-(4-sulfophenylazo)pyrazole-3-carboxylic acid salt, 6-hydroxy-5-(4-sulfophenylazo)-2-naphthalenesulfonic acid salt, 3-hydroxy-4-(4-sulfonaphthylazo)-2,7-naphthalenedisulfonic acid salt, 7-hydroxy-8-(4-sulfonaphthylazo)-1,3-naphthalenedisulfonic acid salt, 3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodospiro[isobenzofuran-1(3H),9′-(9H)xanthene]-3-one salt, 3′,6′-dihydroxy-2′,4′,5′,7′-tetrabromo-4,5,6,7,-tetrachlorospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-3-one salt, 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-3-one salt or flavonoid-based color to the reaction system containing a phenothiazine-derivative color, and then measuring the light absorbance at a wavelength of 610 to 730 nm.

Novel compounds, methods, and compositions for treating various viral infections are described. In some embodiments the novel compounds of the invention are 3-oxo-phenothiazine derivatives; more specific embodiments include 3-oxo-phenothiazine derivatives having substituents at the 1-, 7-, and 9-positions of the phenothiazine parent ring. In other embodiments, the invention provides compositions and methods for treating viral infections, especially HIV.

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

The invention discloses a room temperature phosphorescence molecule based on a phenothiazine derivative, a preparation method and application thereof. The room temperature phosphorescence molecule based on the phenothiazine derivative has a structure shown as formula (I), wherein R is -OCH3, -CH3, -H, -Br, -Cl, -F or -CF3. According to the invention, mainly phenothiazine is adopted as the core, and C-N coupling reaction is carried out to connect phenothiazine with a benzene ring derivative, and then oxidation is carried out to obtain the target product. The solid powder of the compounds all have room temperature phosphorescence phenomenon, and have a longest life up to 398ms, thus being applicable as anti-counterfeit materials. And the preparation method provided by the invention has the advantages of mild reaction conditions and high yield.

The invention discloses a preparation method and application of a phenothiazine derivative. A green organic electroluminescence material disclosed by the invention is based on phenylimidazole and phenothiazine and has the structure formula shown in description, wherein R1, R2 and R3 can be same or different. The phenothiazine derivative has green photoluminescence and high luminous emission efficiency and can be taken as a green material to be applied to electroluminescence devices.

Novel phenothiazine derivatives and their use in the treatment of diabetes mellitus (type I and type II), and as an ovulation inhibitor (contraceptive), cancer chemotherapeutic and / or prophylactic agent, anti-obesity drug (body weight regulator), and immunostimulant.

The preset invention relates to a new method for treating brain tumor with an antipsychotic phenothiazine derivative as a brain tumor cell inhibitor or a brain tumor stem cell inhibitor. In particular, an antipsychotic phenothiazine is accessible to brain via blood-brain barrier, which should be beneficially in treatment of brain tumor.

A method of manufacturing an organic silicon compound that contains a methacryloxy group or an acryloxy group, the method being characterized by the fact that manufacturing or conducting purification by distillation is carried out in the presence of a phenothiazine derivative having a molecular weight equal to or higher than 240. And a stable composition comprising an organic silicon compound that contains a methacryloxy group or an acryloxy group and a phenothiazine derivative having a molecular weight equal to or higher than 240 and used in an amount sufficient to stabilize the aforementioned organic silicon compound.

Compounds for use in a rechargeable battery are provided, including a compound according to the formula:wherein R1 and R9 are independently selected from the group consisting of H, alkyl, aryl, perfluoroaryl, perfluoroalkyl, alkylaryl, alkoxyaryl, alkylcarboxyl, aryl carbonyl, haloalkyl, perfluoroalkyl, glycols, haloaryl, a negative electrolyte, and a polymer, so long as when R1 is H, R9 is not H; and R10 is selected from the group consisting of methyl, alkyl, aryl, alkylaryl, alkoxyaryl, alkylcarboxyl, aryl carbonyl, haloalkyl, perfluoroalkyl, perfluoroaryl, glycols, haloaryl, an oligomer, and a polymer.

The invention discloses a novel phenothiazine derivative and a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention particularly discloses a compound of a structural general formula I and salts, applicable in pharmacy, of the compound, and the compound and the salts can be used as near-infrared fluorescent molecular probes. The invention further provides a preparation method of the molecular probes and application of the molecular probes. Fluorescent molecules are novel in structure, good in sensitivity and selectivity and good in light stability. The molecules and Abeta(1-42) aggregates have good affinity, and meanwhile auto-polymerization of beta-amyloid protein can be well inhibited. Therefore, the probes can be applied to imaging of Abeta amyloid plaque and can be used for treating the Alzheimer's disease.

A method of fracturing a subterranean formation by introducing into the formation a high temperature well treatment fluid containing a polymeric gel and an electron donating compound comprising phenothiazine or a phenothiazine derivative. The high temperature well treatment fluid may further contain a crosslinking agent or the polymeric gel may be crosslinked. The electron donating compound performs as a stabilizer in the treatment of wells having a subterranean formation temperature of up to about 500° F. (260° C.).

The present invention is directed to the use of chemosensitising compounds, in particular thioxanthene derivatives and phenothiazine derivatives, for treatment of infectious diseases in combination with an anti-infective agent. The invention furthermore relates to compositions comprising said chemosensitising compounds and anti-infective agents.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and / or oxidative stress and / or lipid peroxidation.

Enantomerically purified phenothiazines are provided as active ingredients of medicaments to limit activity of bone resorbing cells so as to reduce bone loss. Novel phenothiazine derivatives are provided. A method of synthesizing enantiomerically pure phenothiazine derivatives is provided that avoids post-synthetic enantiomeric resolution.

10H-phenothiazine derivatives capable of inhibiting ferroptosis has structural formula (I). The derivatives, pharmaceutically acceptable salts thereof, crystal forms thereof, or solvates thereof exhibit inhibitory effect on ferroptosis, and therapeutic effect on a rat model of focal cerebral ischemia and thus can be used as a main active ingredient in the preparation of ferroptosis inhibitors. The compounds and the inhibitors prepared by the compounds have good medicinal potential and are expected to be used as drug candidates for the treatment of stroke.