The application provides a
traditional Chinese medicine composition for treating pulmonary arterial hypertension and a preparation method and application thereof, and belongs to the technical field of
traditional Chinese medicine. The
traditional Chinese medicine composition is composed of
ginseng,
astragalus,
cassia bark, prepared licorice, prepared
rehmannia, angelica, white peony root, chuanxiong, persicae
semen and safflower. The preparation method is as follows: water is added to decoct and extract to obtain a traditional Chinese
medicine extract; the traditional Chinese
medicine extract can be further concentrated into a clear paste, and excipients are added to prepare other dosage forms. Animal experiments show that the traditional Chinese
medicine composition can significantly reduce the
pulmonary arterial pressure of a hypoxic pulmonary arterial hypertension model rat, reduce the
right ventricular hypertrophy index, reduce the wall thickness percentage and area percentage of pulmonary arterioles, increase the lumen area percentage of pulmonary arterioles, and effectively improve pulmonary vascular remodeling; clinical cases show that the traditional Chinese medicine composition can significantly improve the symptoms of pulmonary arterial hypertension and
heart failure. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood, removing
blood stasis and dredging collaterals, can be used for preventing and / or treating pulmonary arterial hypertension, and has good safety.