Integrated pipeline consumable device for blood purification

Abstract

The invention relates to the technical field of blood purification, and particularly discloses an integrated blood purification pipeline consumable device which comprises a main body bracket, and an artery pipeline assembly, a dialysis filter, a vein pipeline assembly, a pre-flushing piston assembly, a liquid inlet tank assembly and a liquid outlet tank assembly which are mounted on the main body bracket. The key core problem solved by the invention is to integrate treatment consumable pipelines and integrate a plurality of auxiliary function modules, so that the operation convenience of medical staff is greatly improved on the premise of ensuring treatment; by configuring an automatic pre-flushing function, a heparin injection function, a quantitative system and the like, the operation process of ultralight portable blood purification equipment matched with the device can be simplified, the size and the weight of the equipment are reduced, and the equipment is suitable for wider and more complex application environments; the method can be used for early treatment of severe wounded persons in modern wars, emergency supplement of conventional dialysis treatment patients, disaster relief without traditional dialysis conditions, self-treatment of patients in emergencies and the like, and has wide application prospect and practical value.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of blood purification, and particularly relates to a pipeline consumable device for integrated blood purification. BACKGROUND

[0002] Blood purification refers to the purpose of purifying blood by removing certain pathogenic substances (toxins) in the blood of a patient through a certain blood purification equipment, wherein the blood of the patient is led out of the body. Blood purification includes hemodialysis, hemofiltration, hemoperfusion, blood replacement, immunoadsorption, etc. With the development of blood purification technology and the continuous upgrading of machines, blood purification has been no longer limited to kidney disease treatment, but has become a core technology involving multiple disciplines.

[0003] Firstly, blood purification technology has also been widely used in some disaster emergencies, such as the removal of inflammatory factor storm in patients with severe pneumonia and the treatment of crush syndrome in earthquake disasters. Secondly, in modern wars, various types of war injuries can lead to post-injury sepsis, toxic shock, a high proportion of multiple organ dysfunction such as acute kidney injury and acute liver injury, high myoglobinemia caused by crush injury and extensive muscle injury, multiple organ failure induced by biochemical weapons ionizing radiation damage, and hypothermia injury caused by falling into the sea and soaking in low-temperature seawater after sea battle, etc. These can make the body of the wounded quickly retain a large amount of cell toxins, inflammatory factors, water, etc., which can cause a fatal blow to the microcirculation stability, acid-base balance and internal environment stability. Early and sustainable blood purification treatment for these critically ill trauma patients can remove cell toxins, inflammatory factors and excess water, improve volume status, correct acid-base imbalance and adjust internal homeostasis, and quickly rewarm, which becomes one of the important means to achieve damage control precise resuscitation and creates opportunities for other related treatments and saves lives.

[0004] At present, more than 90% of the market share of domestic hemodialysis machines is occupied by foreign brands. Whether the medical hemodialysis machines produced at home or abroad, the flow metering (including liquid inflow metering, discharge metering and dehydration metering) is a weight weighing method, and each system has at least two or three electronic weight devices. The volume occupied by each weight weighing device is large, so the machine has the characteristics of large occupied space, large weight, inconvenient transportation, high balance requirement, many supporting consumables, high requirement for treatment environment, strong operation professionalism, difficulty in early use at the front line of rescue, and difficulty in realizing uninterrupted treatment of patients during transportation to the hospital. At the same time, the installation process of the supporting consumables is complex and miscellaneous, the integration degree is low, and it is time-consuming and laborious.

[0005] In recent years, portable small hemodialysis machines have been developed and launched overseas. Their common features are small size, easy mobility, and relatively simple operation, and they are designed for patients to operate at home. However, they all control balance through built-in sensors or balance chambers, which requires a high level of treatment environment, have low integration of supporting consumables, and require highly professional operation. They are not suitable for distribution to first-line treatment and uninterrupted treatment during transportation.

[0006] Research on portable blood purification devices has become a hot topic for scholars both domestically and internationally, including portable hemodialysis devices, peritoneal dialysis devices, continuous renal replacement therapy devices, and implantable artificial kidneys. Meanwhile, the integration and high degree of integration of the accompanying consumables are crucial in the research of portable blood purification devices. Summary of the Invention

[0007] The purpose of this invention is to provide an integrated blood purification tubing consumable device that integrates treatment consumable tubing and can be used in conjunction with an ultra-lightweight portable blood purification device. This device enables timely and adequate treatment when blood purification is needed on the front lines of war, in disaster relief efforts, during transport to hospitals, and in other emergencies, thereby reducing casualties and solving the problems encountered in the aforementioned background art.

[0008] To achieve the above objectives, the technical solution of the present invention is as follows: An integrated blood purification tubing consumable device includes a main support frame and an arterial tubing assembly, a dialysis filter, a venous tubing assembly, a pre-flush piston assembly, an inlet tank assembly, and an outlet tank assembly mounted on the main support frame. The dialysis filter is fixed to the main support frame. The arterial and venous tubing assemblies are connected to corresponding interfaces of the dialysis filter via locking devices. The pre-flush piston assembly is fixed to the main support frame and is mounted on the tubing of the arterial tubing assembly. The inlet pipe of the inlet tank assembly is connected to the dialysis filter via the inlet tubing assembly, and the outlet pipe of the dialysis filter is connected to the outlet tank assembly via the outlet tubing assembly. One end of the inlet tubing assembly is connected to the dialysis filter, and the other end is connected to the inlet tank assembly. One end of the outlet tubing assembly is connected to the dialysis filter, and the other end is connected to the outlet tank assembly.

[0009] In the above scheme, the dialysis filter removes accumulated toxins, inflammatory factors, and excess water from the blood through the diffusion and convection of the semi-permeable membrane; both the inlet tank assembly and the outlet tank assembly have standard quantitative volumes; the inlet pipeline assembly includes an inlet pipeline, one end of which is connected to the dialysis filter via a filter inlet connector, and the other end of which is connected to the inlet tank assembly via an inlet check valve; the outlet pipeline assembly includes an outlet pipeline, one end of which is connected to the dialysis filter via a filter outlet connector, and the other end of which is connected to the outlet tank assembly via an outlet Luer connector.

[0010] In the above scheme, the arterial tubing assembly includes an arterial puncture needle, an arterial tubing, and an arterial chamber. The arterial puncture needle is installed at the end of the arterial tubing, and the arterial chamber is connected in the arterial tubing. The top of the arterial chamber is provided with a pre-flush piston assembly connecting pipe and an arterial exhaust pipe. The pre-flush piston assembly connecting pipe is connected to the pre-flush piston assembly. The other end of the arterial tubing is connected to the dialysis filter via a filter blood inlet locking connector.

[0011] In one embodiment, a heparin injection assembly is also provided. The top of the arterial chamber is also provided with a heparin injection assembly connecting line. The heparin injection assembly is installed on the line of the arterial line assembly and connected to the heparin injection assembly connecting line of the arterial line assembly. The heparin injection assembly includes a syringe and a heparin injection line. The syringe is connected to the heparin injection line through a second through-plate Luer connector. The heparin injection line is provided with a heparin clamp on the outside. The heparin injection line is connected to the heparin injection assembly connecting line through a one-way valve.

[0012] In the above scheme, the venous tubing assembly includes a venous puncture needle, a venous tubing, and a venous reservoir. The venous puncture needle is installed at the end of the venous tubing, and the venous reservoir is connected in the venous tubing. The top of the venous reservoir is provided with a venous venting pipe and a blood circuit expansion port. The other end of the venous tubing is connected to the dialysis filter through a blood circuit outlet locking connector.

[0013] The arterial or venous chamber is equipped with an anti-thrombotic filter to intercept blood clots. It also has an air bubble collection function. When there are air bubbles in the blood tubing, they will accumulate in the arterial or venous chamber. Once a certain amount has been collected, the gas can be discharged through the vent on the chamber.

[0014] In the above scheme, the pre-flush piston assembly includes a piston cylinder and a piston installed inside the piston cylinder. A rubber stopper is installed at the end of the piston cylinder, and a first through-plate Luer connector is provided at the working end of the piston cylinder. The piston cylinder is connected to the arterial tubing assembly through the first through-plate Luer connector. Driven by compressed air, the piston of the pre-flush piston assembly pushes the replacement fluid within the tubing consumable device to the ends of the arterial and venous tubing assemblies, where it eventually flows out.

[0015] In the above scheme, the liquid inlet tank assembly includes a liquid inlet tank and a liquid inlet Luer connector. The bottom of the liquid inlet tank is connected to the liquid inlet Luer connector through a liquid inlet tank outlet pipe. The top of the liquid inlet tank is equipped with a liquid inlet tank expansion pipe and a first atmospheric connection interface pipe. A liquid inlet tank clamp is installed on the outside of the liquid inlet tank outlet pipe. A liquid inlet tank expansion port clamp is provided on the outside of the liquid inlet tank expansion pipe, and a liquid inlet tank expansion port plug is installed at the end of the liquid inlet tank expansion pipe. A first atmospheric connection interface clamp is provided on the outside of the first atmospheric connection interface pipe, and a first air filter is installed at the end of the first atmospheric connection interface pipe.

[0016] In the above scheme, the liquid outlet tank assembly includes a liquid outlet tank and a liquid outlet tank extension pipeline. The bottom of the liquid outlet tank is connected to the liquid outlet tank extension pipeline, and a liquid outlet tank extension port plug is installed at the end of the liquid outlet tank extension pipeline. A liquid outlet tank input pipe and a second atmospheric connection interface pipe are installed at the top of the liquid outlet tank. A liquid outlet tank extension port clamp is installed on the outside of the liquid outlet tank extension pipeline. The liquid outlet tank input pipe is connected to the liquid outlet pipeline assembly through a liquid outlet check valve. A second atmospheric connection interface clamp is provided on the outside of the second atmospheric connection interface pipe, and a second air filter is installed at the end of the second atmospheric connection interface pipe.

[0017] Compared with existing technologies, the beneficial effects of this invention are as follows: This consumable device is an ultra-lightweight, portable, and easy-to-operate integrated blood purification tubing consumable. The consumable has an automatic pre-filling function, is equipped with a heparin injection module, a quantitative system, and includes an air bubble collection device and a thrombus filtration device. The key problem solved by this invention is integrating the treatment consumable tubing into a single unit and incorporating multiple auxiliary functional modules. This greatly improves the ease of operation for medical personnel while ensuring treatment, reduces the possibility of installation errors, and shortens the installation time. The automatic pre-filling function, heparin injection function, and quantitative system simplify the operation of the ultra-lightweight portable blood purification equipment, reduce the size and weight of the equipment, and make it suitable for a wider range of complex application environments, such as early treatment of critically injured patients in modern warfare, emergency replenishment for patients undergoing routine dialysis, disaster relief in areas without traditional dialysis facilities, and patient self-treatment in emergencies. It has broad application prospects and practical value. Attached Figure Description

[0018] The disclosure of this invention is illustrated with reference to the accompanying drawings. It should be understood that the drawings are for illustrative purposes only and are not intended to limit the scope of protection of this invention. In the drawings, the same reference numerals are used to refer to the same parts. Wherein: Figure 1 This is an isometric schematic diagram of the present invention; Figure 2 This is an isometric schematic diagram of the arterial tubing assembly of the present invention; Figure 3 This is an isometric schematic diagram of the vein conduit assembly of the present invention; Figure 4 This is a cross-sectional schematic diagram of the pre-flush piston assembly of the present invention; Figure 5 This is an isometric schematic diagram of the heparin injection assembly of the present invention; Figure 6 This is an isometric schematic diagram of the liquid inlet tank assembly of the present invention; Figure 7 This is an isometric schematic diagram of the liquid inlet pipeline assembly of the present invention; Figure 8 This is an isometric schematic diagram of the liquid outlet pipeline assembly of the present invention; Figure 9 This is an isometric schematic diagram of the liquid outlet tank assembly of the present invention; Figure 10 This is a schematic diagram of the overall structure of the present invention; Figure 11 This is a schematic diagram of the structure of the present invention from another perspective. Detailed Implementation

[0019] To make the technical means, creative features, objectives, and effects of this invention readily understandable, the invention will now be described in further detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, illustrating only the basic structure of the invention, and therefore only show the relevant components of the invention.

[0020] According to the technical solution of the present invention, without changing the essential spirit of the present invention, those skilled in the art can propose various interchangeable structural methods and implementations. Therefore, the following detailed embodiments and accompanying drawings are merely exemplary descriptions of the technical solution of the present invention, and should not be regarded as the entirety of the present invention or as a limitation or restriction of the technical solution of the present invention.

[0021] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments.

[0022] Example 1, as Figure 1 , Figure 10 , Figure 11 As shown, the integrated blood purification tubing consumable device includes a main support 1 and arterial tubing assembly 2, dialysis filter 3, venous tubing assembly 4, pre-flush piston assembly 5, inlet tank assembly 7, and outlet tank assembly 10, all mounted on the main support 1. The main support 1 has two platform-like structures, with slots or interfaces on the platforms for engaging with each component, facilitating secure installation.

[0023] The dialysis filter 3 is fixed to the two platforms of the main support 1. The arterial tubing assembly 2 and the venous tubing assembly 4 are connected to the corresponding interfaces of the dialysis filter 3 through locking devices. The pre-flush piston assembly 5 is fixed to the main support 1 and is installed on the tubing of the arterial tubing assembly 2. The inlet pipe of the inlet tank assembly 7 is connected to the bottom inlet pipe of the dialysis filter 3 through the inlet pipe assembly 8. The outlet pipe on the top side of the dialysis filter 3 is connected to the outlet tank assembly 10 through the outlet pipe assembly 9. One end of the inlet pipe assembly 8 is connected to the dialysis filter 3, and the other end is connected to the inlet tank assembly 7. One end of the outlet pipe assembly 9 is connected to the dialysis filter 3, and the other end is connected to the outlet tank assembly 10.

[0024] In specific implementation, such as Figure 1 , Figure 2 , Figure 3 , Figure 7 , Figure 8 As shown, the main support 1 serves as the base for the integrated blood purification consumable. The dialysis filter 3 is fixed to the main support 1 with bolts and nuts, occupying the space of the upper and lower platforms. The arterial tubing assembly 2 and the venous tubing assembly 4 are connected to the corresponding interfaces of the dialysis filter 3 through the filter blood inlet locking connector 213 and the filter blood outlet locking connector 411, respectively. The arterial reservoir 207 and the venous reservoir 404 on the tubing are respectively locked in the corresponding interface positions of the main support 1. The pre-flush piston assembly 5 and the heparin injection assembly 6 are locked to the main support 1 through the first perforated plate Luer connector 505 and the second perforated plate Luer connector 602, respectively. One end of the inlet tubing assembly 8 is connected to the dialysis filter 3 through the filter inlet port connection connector 801, and the other end is connected to the inlet tank assembly 7 through the inlet one-way valve 803. The inlet tank assembly 7 is locked in its corresponding installation position on the main support 1. One end of the liquid outlet pipeline assembly 9 is connected to the dialysis filter 3 via the filter outlet connector 901, and the other end is connected to the liquid outlet tank assembly 10 via the liquid outlet Luer connector 903, and the liquid outlet tank assembly 10 is secured in its corresponding installation position on the main support 1.

[0025] Finally, the patient's artery is punctured through the arterial puncture needle 201 of the arterial conduit assembly 2, and the patient's vein is punctured through the venous puncture needle 401 of the venous conduit assembly 4, thereby forming a closed-loop blood circuit for extracorporeal blood circulation therapy.

[0026] In the above scheme, the dialysis filter 3 simulates the filtration function of the kidney, removing toxins, inflammatory factors, and excess water accumulated in the blood through the diffusion and convection of the semi-permeable membrane. Both the inlet tank assembly 7 and the outlet tank assembly 10 have standard quantitative volumes. This standard quantitative volume design for both inlet and outlet eliminates the need to consider the impact of acceleration changes on balance accuracy in existing technologies, enabling use in turbulent environments. It can be widely applied in special environments such as war fronts and disaster relief fronts, demonstrating broad application prospects and practical value.

[0027] Example 2, based on the solution of Example 1, please refer to... Figure 2 The arterial tubing assembly 2 includes an arterial puncture needle 201, an arterial tubing, and an arterial reservoir 207. The arterial puncture needle 201 is installed at the end of the arterial tubing, and the arterial reservoir 207 is connected in the arterial tubing. The top of the arterial reservoir 207 is provided with a pre-flush piston assembly connecting pipe 208 and an arterial exhaust pipe 209. The pre-flush piston assembly connecting pipe 208 is connected to the pre-flush piston assembly 5. The other end of the arterial tubing is connected to the dialysis filter 3 through a filter blood inlet locking connector 213.

[0028] For specific implementation details, please refer to [link / reference]. Figure 2 As shown, the arterial tubing assembly 2 is composed of an arterial puncture needle 201, arterial tubing segment a 203, an equal-diameter connector 204, a blood pump tubing 205, arterial tubing segment b 206, an arterial reservoir 207, arterial tubing segment c 212, and a filter blood inlet locking connector 213 connected in series. Arterial clamps 202 are movably distributed on the outside of arterial tubing segment a 203. A pre-flush piston assembly 5 is connected to the arterial reservoir 207 via a pre-flush piston assembly connecting line 208. A heparin injection assembly 6 is connected to the arterial reservoir 207 via a heparin injection assembly connecting line 214. An arterial venting line 209, an arterial venting clamp 210, and an arterial venting port locking cap 211 are connected in series on the top of the arterial reservoir 207.

[0029] The aforementioned upper artery tubing assembly 2 includes an arterial reservoir 207, which contains an anti-thrombotic filter to prevent thrombi from detaching and flowing back into the patient's body with the blood, potentially causing embolism. It also serves to collect air bubbles. When air bubbles are present in the arterial bloodstream, they accumulate in the arterial reservoir 207. Once a certain amount has been collected, the gas can be released by unscrewing the arterial vent cap 211 and opening the arterial vent clamp 210.

[0030] Example 3, based on the scheme of Example 1, is an integrated blood purification tubing consumable device, including a main support 1 and an arterial tubing assembly 2, a dialysis filter 3, a venous tubing assembly 4, a pre-filling piston assembly 5, an inlet tank assembly 7, an outlet tank assembly 10 installed on the main support 1, and also includes a heparin injection assembly 6.

[0031] Because the top of the arterial chamber 207 is also equipped with a heparin injection assembly connection line 214, the heparin injection assembly 6 is installed on the arterial conduit assembly 2 and connected to the heparin injection assembly connection line 214 of the arterial conduit assembly 2. Please refer to... Figure 5 The heparin injection assembly 6 includes a syringe 601 and a heparin injection line 604. The syringe 601 is connected to the heparin injection line 604 through a second through-plate Luer connector 602. A movable heparin clamp 603 is inserted through the outside of the heparin injection line 604. The heparin injection line 604 is connected to the heparin injection assembly connecting line 214 through a one-way valve 605.

[0032] For specific implementation details, please refer to [link / reference]. Figure 5 As shown, the heparin injection assembly 6 is connected to the arterial chamber 207 branch via the heparin injection assembly connecting line 214. When anticoagulants are needed during patient treatment, the heparin clamp 603 can be opened, and the anticoagulant syringe 601 can be manually pushed to inject the anticoagulant into the arterial chamber 207. The specific injection volume depends on the doctor's orders. If anticoagulants are not needed, the above steps are not required. A one-way valve 605 is connected in series on the heparin injection assembly 6 to prevent blood in the extracorporeal circulation circuit from flowing back into the heparin syringe 601.

[0033] Example 4, based on the scheme of Example 1, see [link / reference] Figure 3 As shown, the intravenous tubing assembly 4 includes an intravenous puncture needle 401, an intravenous tubing, and an intravenous reservoir 404. The intravenous puncture needle 401 is installed at the end of the intravenous tubing, and the intravenous reservoir 404 is connected in the intravenous tubing. The top of the intravenous reservoir 404 is provided with an intravenous venting pipe 405 and a blood passage expansion port 408. The other end of the intravenous tubing is connected to the dialysis filter 3 through a blood passage outlet locking connector 411.

[0034] For specific implementation details, please refer to [link / reference]. Figure 3 As shown, the intravenous tubing assembly 4 is composed of an intravenous puncture needle 401, intravenous tubing section a 403, intravenous reservoir 404, intravenous tubing section b 410, and filter blood circuit outlet locking connector 411 connected in series. The intravenous clamp 402 is movably distributed on the intravenous tubing section a 403. The intravenous venting tubing 405, the intravenous venting clamp 406, and the intravenous venting port locking cap 407 are connected in series on the intravenous reservoir 404 to expel air bubbles. The blood circuit expansion port 408 and the expansion port locking cap 409 are connected in series on another branch port of the intravenous reservoir 404.

[0035] The aforementioned venous tubing assembly 4 includes a venous reservoir 404, which contains an anti-thrombotic filter to prevent thrombi from detaching and flowing back into the patient's body with the blood, potentially causing embolism. It also serves to collect air bubbles. When air bubbles are present in the venous bloodstream, they accumulate in the venous reservoir 404. Once a certain amount has been collected, the air can be released by unscrewing the venous vent locking cap 407 and opening the venous vent clamp 406. In case of emergencies such as requiring additional medication, the expansion port locking cap 409 can be unscrewed, allowing medication to be injected into the extracorporeal circulation system through the bloodstream expansion port 408.

[0036] Based on Examples 1-4, this integrated consumable includes an arterial puncture needle 201 and a venous puncture needle 401. The venous puncture needle 401 is used to puncture the patient's vein, and the arterial puncture needle 201 is used to puncture the patient's artery. Then, the arterial clamp 202 and the venous clamp 402 are opened. Using the auxiliary power of the ultra-light portable blood purification device, blood flows unidirectionally outside the body into the dialysis membrane bundle in the dialysis filter 3. Relying on the diffusion, convection, and ultrafiltration principles of blood purification, the concentration difference and pressure difference between the dialysis filter membrane bundle and the dialysate chamber are used to quantitatively remove toxins, inflammatory factors, and excess water.

[0037] Example 5, based on the scheme of Example 1, see [link / reference] Figure 4 The pre-flush piston assembly 5 includes a piston cylinder 501 and a piston 502 installed inside the piston cylinder 501. A rubber plug 503 is installed at the end of the piston cylinder 501. A first through-plate Luer connector 505 is provided at the working end of the piston cylinder 501. The piston cylinder 501 is connected to the arterial tubing assembly 2 through the first through-plate Luer connector 505.

[0038] During the pre-flushing operation, the piston 502 of the pre-flushing piston assembly 5, driven by compressed air, pushes the replacement fluid in the consumable tubing device to the ends of the arterial tubing assembly 2 and the venous tubing assembly 4, and finally flows out.

[0039] Because this integrated consumable has arterial and venous puncture needles, switch clamps, and pre-flushing piston assembly 5, the switch clamps on the arterial and venous puncture needle lines are opened before treatment. The piston 502 in the pre-flushing piston assembly 5, driven by compressed air, pushes the replacement fluid in the integrated consumable into the arterial and venous lines, which flows out from the arterial and venous puncture needle ports, thus pre-flushing the puncture needles. After pre-flushing is completed, the clamps are closed.

[0040] For specific implementation details, please refer to [link / reference]. Figure 4As shown, the pre-filling piston assembly 5 is connected to the branch of the arterial chamber 207 via the pre-filling piston assembly connecting pipe 208. The piston cylinder 501 contains a certain volume of compressed gas between the piston 502 and the rubber stopper 503. In the initial state of the integrated blood purification consumable, the arterial clamp 202 and the venous clamp 402 are both in the closed state. Before treatment, the arterial clamp 202 and the venous clamp 402 are opened, the pressure of the compressed gas in the pre-filling piston assembly 5 is released, and the pre-filling fluid in the integrated blood purification consumable is used as the replacement fluid to flow out to both ends of the arterial puncture needle 201 and the venous puncture needle 401, thereby cleaning the needles.

[0041] Example 6, based on the scheme of Example 1, see [link / reference] Figure 6 As shown, the liquid inlet assembly 7 includes a liquid inlet tank 701 and a liquid inlet Luer connector 704. The bottom of the liquid inlet tank 701 is connected to the liquid inlet Luer connector 704 via a liquid inlet tank outlet pipe 702. A liquid inlet tank extension pipe 706 and a first atmospheric connection interface pipe 709 are installed on the top of the liquid inlet tank 701. A movable liquid inlet tank clamp 703 is installed on the outside of the liquid inlet tank outlet pipe 702 to restrict the flow of internal liquid. A liquid inlet tank extension port clamp 705 is provided on the outside of the liquid inlet tank extension pipe 706, also for restricting the flow of internal liquid. A liquid inlet tank extension port plug 707 is installed at the end of the liquid inlet tank extension pipe 706. A first atmospheric connection interface clamp 708 is provided on the outside of the first atmospheric connection interface pipe 709 for venting when opened. A first air filter 710 is installed at the end of the first atmospheric connection interface pipe 709.

[0042] For specific implementation, please refer to Figure 6 As shown, the inlet tank assembly 7 is installed in the corresponding mounting hole of the main support 1, and is connected to the dialysis filter 3 through the inlet pipeline assembly 8. The inlet tank output pipe 702, inlet tank clamp 703, and Luer connector 704 are connected in series at the lower interface of the inlet tank 701. The first atmospheric connection interface clamp 708, first atmospheric connection interface pipe 709, and first air filter 710 are connected in series at the upper branch port of the inlet tank 701 to connect to atmospheric pressure, ensuring that the pressure inside the tank is the same as the external pressure and isolating bacteria in the air. The inlet tank expansion port clamp 705, inlet tank expansion pipe 706, and inlet tank expansion port plug 707 are connected in series at the upper branch port of the inlet tank 701, which can be used to connect external treatment fluid bags, etc. The inlet tank 701 contains a treatment fluid, providing a quantitative dose of treatment fluid.

[0043] As a preferred option, see Figure 7 As shown, the liquid inlet pipeline assembly 8 includes a liquid inlet pipeline 802. One end of the liquid inlet pipeline 802 is connected to the dialysis filter 3 through the filter inlet port connector 801, and the other end of the liquid inlet pipeline 802 is connected to the liquid inlet tank assembly 7 through the liquid inlet check valve 803.

[0044] Example 7, based on the solution of Example 1, please refer to... Figure 9 The liquid outlet assembly 10 includes a liquid outlet tank 1001 and a liquid outlet tank extension pipe 1008. The bottom of the liquid outlet tank 1001 is connected to the liquid outlet tank extension pipe 1008, and a liquid outlet tank extension port plug 1009 is installed at the end of the liquid outlet tank extension pipe 1008. A liquid outlet tank inlet pipe 1002 and a second atmospheric connection interface pipe 1005 are installed on the top of the liquid outlet tank 1001. A liquid outlet tank extension port clamp 1007, which can be used to cut off the liquid in the internal pipeline, is installed on the outside of the liquid outlet tank extension pipe 1008. The liquid outlet tank inlet pipe 1002 is connected to the liquid outlet pipeline assembly 9 through a liquid outlet check valve 1003 to prevent backflow. A second atmospheric connection interface clamp 1004 is provided on the outside of the second atmospheric connection interface pipe 1005, and a second air filter 1006 is installed at the end of the second atmospheric connection interface pipe 1005.

[0045] For specific implementation, please refer to Figure 9 As shown, the discharge tank assembly 10 is installed in the corresponding mounting hole of the main support 1, and is connected to the dialysis filter 3 through the discharge pipeline assembly 9. The discharge tank inlet pipe 1002 and the discharge check valve 1003 are sequentially connected to the upper branch port of the discharge tank 1001 to receive treatment waste fluid, and the discharge check valve 1003 prevents the discharged waste fluid from flowing back into the dialysis filter 3. The atmospheric connection interface clamp 1004, the atmospheric connection interface pipeline 1005, and the air filter 1006 are sequentially connected in series at the upper branch port of the discharge tank 1001 to connect to atmospheric pressure, ensuring that the pressure inside the tank is the same as the external pressure and isolating bacteria in the air. The discharge tank expansion port clamp 1007, the discharge tank expansion pipeline 1008, and the discharge tank expansion port plug 1009 are sequentially connected in series at the lower interface of the discharge tank 1001, and can be used to connect external waste bags, etc. The discharge tank 1001 is initially empty and serves to collect waste liquid discharged during treatment in a quantitative manner.

[0046] As a preferred option, see Figure 8 As shown, the liquid outlet pipeline assembly 9 includes a liquid outlet pipeline 902. One end of the liquid outlet pipeline 902 is connected to the dialysis filter 3 through the filter outlet connector 901, and the other end of the liquid outlet pipeline 902 is connected to the liquid outlet tank assembly 10 through the liquid outlet Luer connector 903.

[0047] Example 8, please continue reading Figure 1 , Figure 10 , Figure 11As described in Examples 1-7 above, the integrated blood purification tubing consumable device includes, in addition to the entire consumable device, a drive controller located outside the consumable device, and arterial tubing assembly 2, dialysis filter 3, venous tubing assembly 4, pre-flush piston assembly 5, heparin injection assembly 6, inlet tank assembly 7, and outlet tank assembly 10 connected to the drive controller. The process controllability of the consumable device is achieved according to the built-in conventional logic algorithm.

[0048] The inlet tank assembly 7, the inlet pipeline assembly 8, the dialysis filter 3, the outlet pipeline assembly 9, and the outlet tank assembly 10 are connected in sequence to form the water circuit part of the integrated consumable for blood purification. When the blood purification equipment is operated, the inlet tank assembly 7 delivers the treatment fluid to the lower side interface of the dialysis filter 3 through the inlet pipeline assembly 8, and then flows out through the upper side interface of the dialysis filter 3, and flows out through the outlet pipeline assembly 9 to the outlet tank assembly 10.

[0049] This integrated consumable includes an inlet tank assembly 7, which is mounted on the main support 1 and connected to its corresponding inlet line 802 via an inlet Luer connector 704. The inlet tank clamp 703 is then opened. The inlet tank 701 contains dialysate, providing a quantitative amount of dialysate for treatment.

[0050] The integrated consumable includes a liquid dispensing tank assembly 10, which is mounted on the main support 1. The liquid dispensing tank pipeline has a one-way valve 1003, allowing liquid to flow only into the dispensing tank 1001 and preventing it from flowing out of the pipeline. The one-way valve 1003 integrates a Luer connector, which connects to its corresponding dispensing pipeline 902. The dispensing tank 1001 is empty and serves to quantitatively collect waste liquid discharged during treatment.

[0051] Because both the inlet and outlet tanks have standardized, quantitative volumes, traditional unlimited-volume dialysis is transformed into fixed-volume ultrafiltration and balancing. Therefore, it eliminates the need to consider the impact of acceleration changes on balancing accuracy, enabling use even in bumpy or swaying environments. This integrated consumable is part of an ultralight, portable blood purification device, used in conjunction with the drive controller in the blood purifier's power-assisted monitoring module to perform blood purification treatment on patients.

[0052] This invention discloses a highly integrated and user-friendly integrated blood purification tubing consumable. The consumable features an automatic pre-filling function, a heparin injection component 6, and inlet / outlet fluid tanks with a metering system, as well as an air bubble collection device and a thrombus filtration device. The key problem solved by this invention is integrating the treatment consumable tubing into a single unit and incorporating multiple auxiliary functional modules. This significantly improves the ease of operation for medical personnel while ensuring treatment safety, reduces the possibility of installation errors, and shortens the installation time.

[0053] By configuring automatic pre-flushing, heparin injection, and quantitative systems, the operation of the ultra-lightweight portable blood purification equipment can be simplified, reducing the size and weight of the equipment and making it suitable for a wider range of complex application environments, such as early treatment of critically injured patients in modern warfare, emergency supplementation for patients undergoing routine dialysis treatment, disaster relief in areas without traditional dialysis facilities, and self-treatment for patients in emergencies. It has broad application prospects and practical value.

[0054] Furthermore, the present invention has the following outstanding beneficial effects: (1) High degree of integration: In addition to the basic functions used in the industry, this consumable also integrates automatic pre-filling function, heparin injection module, quantitative system, bubble collection device, thrombus filtration device, etc., and can effectively reduce the volume and weight of the ultra-light portable blood purification equipment.

[0055] (2) The consumables are easy to install. The integrated design of the consumables allows for easy installation on the matching blood purification equipment, simplifying the complex consumable installation steps of traditional blood purification equipment and reducing the difficulty and time of consumable installation. The highly integrated design greatly reduces the weight of the matching blood purification equipment and simplifies the consumable installation operation and pre-treatment priming operation.

[0056] (3) Simple operation. This invention not only simplifies the installation of consumables, but also simplifies the pre-flushing steps of consumables before blood purification treatment. Traditional equipment requires the input of pre-flushing fluid to clean and vent the extracorporeal circulation pipeline after the consumables are installed. However, the consumables in this invention are already pre-flushed with pre-flushing fluid and have a pre-flushing piston assembly design. It is only necessary to open the arterial and venous clamps to release the piston pressure for pre-flushing, which greatly simplifies the pre-flushing steps before treatment and shortens the preparation time.

[0057] (4) The treatment environment requirements are low. Traditional blood purification equipment mainly uses weighing to measure flow rate, which is not only bulky and heavy, but also requires high balance, making it difficult to apply in many scenarios. The integrated consumables of this invention have standardized quantitative inlet and outlet tank components, changing the traditional unlimited dialysis to fixed-rate ultrafiltration and balance. Therefore, it is no longer necessary to consider the impact of acceleration changes on balance accuracy, enabling use in bumpy and swaying environments. Thus, it can be widely used in special environments such as the front lines of war and disaster relief, and has broad application prospects and practical value.

[0058] This invention, as an integrated consumable component of an ultralight portable blood purification device, can be used in conjunction with the device to provide a technical means for the early and simultaneous blood purification treatment of critically injured patients in large numbers during wartime. This helps achieve the goal of early damage control and precise resuscitation after injury, buying time for subsequent systemic treatment and becoming an important means of damage control and precise resuscitation in the early treatment of critically injured patients in modern warfare. It can also serve as an emergency supplementary solution for patients undergoing routine dialysis treatment, bridging the gap between home and hospital care and reducing the frequency of regular dialysis. Furthermore, it can be used for self-treatment of patients in disaster relief and emergencies where traditional dialysis is unavailable (such as patients isolated during epidemics, patients trapped in earthquakes, and patients with severe trauma). It has broad application prospects and practical value.

[0059] It should be noted that, in this document, relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. These undisclosed elements are all prior art known to those skilled in the art.

[0060] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A tubing set for integrated blood purification, characterized by: The application relates to a dialysis device, which comprises a main support (1), an arterial pipeline assembly (2), a dialysis filter (3), a venous pipeline assembly (4), a preflush piston assembly (5), an inflow tank assembly (7) and an outflow tank assembly (10). The dialysis filter (3) is fixed on the main support (1), the arterial pipeline assembly (2) and the venous pipeline assembly (4) are connected with corresponding interfaces of the dialysis filter (3) through locking members, the preflush piston assembly (5) is fixed on the main support (1), the preflush piston assembly (5) is installed on a pipeline of the arterial pipeline assembly (2), an inflow pipe of the inflow tank assembly (7) is connected with the dialysis filter (3) through an inflow pipeline assembly (8), an outflow pipe of the dialysis filter (3) is connected with the outflow tank assembly (10) through an outflow pipeline assembly (9), one end of the inflow pipeline assembly (8) is connected with the dialysis filter (3), and the other end of the inflow pipeline assembly (8) is connected with the inflow tank assembly (7); one end of the outflow pipeline assembly (9) is connected with the dialysis filter (3), and the other end of the outflow pipeline assembly (9) is connected with the outflow tank assembly (10).

2. The integrated blood purification tubing consumable set of claim 1, wherein: The dialysis filter (3) removes accumulated toxins, inflammatory factors and excess water in blood through diffusion and convection of a semi-permeable membrane; the inflow tank assembly (7) and the outflow tank assembly (10) are standard quantitative volume. The inflow pipeline assembly (8) comprises an inflow pipeline (802), one end of the inflow pipeline (802) is connected with the dialysis filter (3) through a filter inflow port connecting joint (801), and the other end of the inflow pipeline (802) is connected with the inflow tank assembly (7) through an inflow one-way valve (803). The outflow pipeline assembly (9) comprises an outflow pipeline (902), one end of the outflow pipeline (902) is connected with the dialysis filter (3) through a filter outflow port connecting joint (901), and the other end of the outflow pipeline (902) is connected with the outflow tank assembly (10) through an outflow luer joint (903).

3. The integrated blood purification tubing set of claim 1, wherein: The arterial pipeline assembly (2) comprises an arterial puncture needle (201), an arterial pipeline and an arterial pot (207), the arterial puncture needle (201) is installed at the end of the arterial pipeline, the arterial pot (207) is connected in the arterial pipeline, the top of the arterial pot (207) is provided with a preflush piston assembly connecting pipeline (208) and an arterial exhaust pipeline (209), the preflush piston assembly connecting pipeline (208) is connected with the preflush piston assembly (5), and the other end of the arterial pipeline is connected with the dialysis filter (3) through a filter blood path inlet locking joint (213).

4. The integrated blood purification tubing set of claim 3, wherein: A heparin injection assembly (6) is further arranged, the top of the arterial pot (207) is further provided with a heparin injection assembly connecting pipeline (214), the heparin injection assembly (6) is installed on the pipeline of the arterial pipeline assembly (2) and connected in the heparin injection assembly connecting pipeline (214) of the arterial pipeline assembly (2). The heparin injection assembly (6) comprises a syringe (601) and a heparin injection pipeline (604), the syringe (601) is connected with the heparin injection pipeline (604) through a second through-plate luer joint (602), the outside of the heparin injection pipeline (604) is provided with a heparin tube clamp (603), and the heparin injection pipeline (604) is connected with a heparin injection assembly connecting pipeline (214) through a one-way valve (605).

5. The integrated blood purification tubing set of claim 3, wherein: The venous pipeline assembly (4) comprises a venous puncture needle (401), a venous pipeline and a venous jug (404), the venous puncture needle (401) is installed at the end of the venous pipeline, and the venous jug (404) is connected in the venous pipeline; the top of the venous jug (404) is provided with a venous exhaust pipeline (405) and a blood path expansion port (408), and the other end of the venous pipeline is connected with a dialysis filter (3) through a filter blood path outlet locking joint (411).

6. The integrated blood purification tubing set of claim 5, wherein: The jug of the arterial jug (207) or the venous jug (404) is provided with an anti-thrombus filter screen, which is used for intercepting thrombus; meanwhile, the arterial jug (207) or the venous jug (404) has a bubble collecting function, when there are bubbles in the blood pipeline, the bubbles will be gathered to the arterial jug (207) or the venous jug (404), and when a certain amount of bubbles are collected, the bubbles can be exhausted through the exhaust port of the jug.

7. The integrated blood purification tubing consumable set of claim 1, wherein: The pre-flushing piston assembly (5) comprises a piston cylinder (501) and a piston (502) installed in the piston cylinder (501), the end of the piston cylinder (501) is provided with a rubber plug (503), the working end of the piston cylinder (501) is provided with a first through-plate luer joint (505), and the piston cylinder (501) is connected with the arterial pipeline assembly (2) through the first through-plate luer joint (505).

8. The integrated blood purification tubing set of claim 7, wherein: The piston (502) of the pre-flushing piston assembly (5) is pushed by compressed air to push the displacement liquid in the pipeline consumable device to the pipeline end of the arterial pipeline assembly (2) and the venous pipeline assembly (4), and finally flows out.

9. The integrated blood purification tubing consumable set of claim 1, wherein: The liquid inlet tank assembly (7) comprises a liquid inlet tank (701) and a liquid inlet luer joint (704), the bottom of the liquid inlet tank (701) is connected with the liquid inlet luer joint (704) through a liquid inlet tank output pipe (702); the top of the liquid inlet tank (701) is provided with a liquid inlet tank expansion pipeline (706) and a first atmospheric communication interface pipeline (709); The outside of the liquid inlet tank output pipe (702) is provided with a liquid inlet tank pipe clamp (703); the outside of the liquid inlet tank expansion pipeline (706) is provided with a liquid inlet tank expansion port pipe clamp (705), and the end of the liquid inlet tank expansion pipeline (706) is provided with a liquid inlet tank expansion port plug cover (707); the outside of the first atmospheric communication interface pipeline (709) is provided with a first atmospheric communication interface pipe clamp (708), and the end of the first atmospheric communication interface pipeline (709) is provided with a first air filter (710).

10. The integrated blood purification tubing consumable set of claim 1, wherein: The liquid outlet tank assembly (10) comprises a liquid outlet tank (1001) and a liquid outlet tank extension pipeline (1008), the bottom of the liquid outlet tank (1001) is connected with the liquid outlet tank extension pipeline (1008), and the end of the liquid outlet tank extension pipeline (1008) is provided with a liquid outlet tank extension port cover (1009); the top of the liquid outlet tank (1001) is provided with a liquid outlet tank input pipeline (1002) and a second atmosphere communication interface pipeline (1005); The outer side of the liquid outlet tank extension pipeline (1008) is provided with a liquid outlet tank extension port pipeline clamp (1007); the liquid outlet tank input pipeline (1002) is connected with a liquid outlet pipeline assembly (9) through a liquid outlet one-way valve (1003); the outer side of the second atmosphere communication interface pipeline (1005) is provided with a second atmosphere communication interface pipeline clamp (1004), and the end of the second atmosphere communication interface pipeline (1005) is provided with a second air filter (1006).

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