Phyllanthus emblica leaf extractive preparation method and preparation and anti-aids application thereof

A technology of cotyledon leaves and extracts is applied in the field of preparation of cotyledon leaves, can solve the problems of clinical effect, anti-skin and mucous membrane lesions, unsatisfactory long-term intervention effect, etc., and achieves enhancement of immunity, simple equipment, and improved purity. Effect

Active Publication Date: 2018-06-29
PHARMA FACTORY GUANGXI MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few anti-AIDS traditional Chinese medicines and ethnic medicine preparations on the market, and the clinical effects, anti-skin and mucous membrane lesions and long-term intervention effects are not ideal

Method used

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  • Phyllanthus emblica leaf extractive preparation method and preparation and anti-aids application thereof
  • Phyllanthus emblica leaf extractive preparation method and preparation and anti-aids application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of emblica cotyledon extract, comprising the following steps:

[0033] (1) Soaking: take emblica cotyledon leaves, add distilled water to the pulverized material after crushing, and soak for 8 hours;

[0034] (2) Beating and enzymatic hydrolysis: adding water to the soaked emblica cotyledons to crush and beat, then adding cellulase to the obtained slurry for enzymatic hydrolysis treatment to obtain an enzymatic hydrolysis solution; the solid-to-liquid ratio of the slurry is 1:2; The dosage of the cellulase is 0.2% of the total mass of the slurry, the temperature of the enzymolysis treatment is 32°C, and the enzymolysis time is 2h;

[0035] (3) Carbon dioxide supercritical extraction: put the enzymolysis liquid obtained in step (2) into the extractor, and carry out carbon dioxide supercritical extraction. h;

[0036] (4) Separation: the extracted mixture is then separated in a separation tank at a pressure of 7 MPa and a temperature of 28° C. to obta...

Embodiment 2

[0040] A preparation method of emblica cotyledon extract, comprising the following steps:

[0041] (1) Soaking: take emblica cotyledon leaves, add distilled water to the pulverized material after crushing, and soak for 5 hours;

[0042] (2) Beating and enzymatic hydrolysis: adding water to the soaked emblica cotyledons to crush and beat, and then adding cellulase to the obtained slurry for enzymatic hydrolysis treatment to obtain an enzymatic hydrolysis solution; the solid-to-liquid ratio of the slurry is 1:1; The dosage of the cellulase is 0.1% of the total mass of the slurry, the temperature of the enzymolysis treatment is 32°C, and the enzymolysis time is 2.5h;

[0043] (3) Carbon dioxide supercritical extraction: put the enzymolysis solution obtained in step (2) into the extractor, and carry out carbon dioxide supercritical extraction. The extraction temperature is 35°C, the pressure is 30MPa, the extraction flow rate is 50L / h, and the time is 2h ;

[0044] (4) Separatio...

Embodiment 3

[0048] A preparation method of emblica cotyledon extract, comprising the following steps:

[0049] (1) Soaking: take emblica cotyledon leaves, add distilled water to the crushed material after crushing, and soak for 10 hours;

[0050] (2) Beating and enzymatic hydrolysis: adding water to the soaked emblica cotyledons to crush and beat, and then adding cellulase to the obtained slurry for enzymatic hydrolysis treatment to obtain an enzymatic hydrolysis solution; the solid-to-liquid ratio of the slurry is 1:3; The dosage of the cellulase is 0.3% of the total mass of the slurry, the temperature of the enzymolysis treatment is 35°C, and the enzymolysis time is 1.5h;

[0051] (3) Carbon dioxide supercritical extraction: put the enzymolysis solution obtained in step (2) into the extractor, and carry out carbon dioxide supercritical extraction. The extraction temperature is 45°C, the pressure is 20MPa, the extraction flow rate is 65L / h, and the time is 1h ;

[0052] (4) Separation:...

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Abstract

The invention discloses a phyllanthus emblica leaf extractive preparation method which comprises the following steps: (1) soaking; (2) pulping and performing enzymolysis; (3) performing carbon dioxidesupercritical extraction; (4) separating; (5) distilling and freeze drying to obtain the phyllanthus emblica leaf extractive. According to the preparation method disclosed by the invention, are soaked and activating treatment is performed at first and then the activated phyllanthus emblica leaves are subjected to crush and pulp, and enzymolysis treatment is performed; thus, cell walls of the phyllanthus emblica leaves are damaged, the phyllanthus emblica particles are refined, effective ingredients in the phyllanthus emblica leaves can be extracted out more easily, quality is improved, and extracting time is shortened; then the carbon dioxide supercritical extracting method is utilized to extract the active ingredients of the phyllanthus emblica leaves, the purity is high, damage to the active ingredients is effectively reduced, and quality of a finished product is ensured. The phyllanthus emblica leaf extractive prepared by the preparation method disclosed by the invention can be added into pharmaceutical adjuvant to be prepared into corresponding preparation, can be applied to treating or assisting to treat aids, can strengthen patient physique and can improve patient life quality.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of an emblica cotyledon extract and its preparation and anti-AIDS application. Background technique [0002] Emlical leaves are the leaves of small deciduous trees or shrubs of the genus Phyllan-thus in the Euphorbiaceae (Euphorbiaceae), also known as oil orange leaves and silk leaves. Efficacy, for edema, skin eczema. Amla cotyledon is a commonly used folk medicinal material, which has been recorded both at home and abroad. For example, Indonesia often uses it as an antidiarrheal agent to treat gastrointestinal diseases; Guangxi folks often use dried emblica cotyledons as pillows. [0003] Studies have shown that the cotyledon emblica contains organic phenolic acids, reducing sugars, polysaccharides, flavonoids, triterpenes and other components. Some researchers have studied the chemical components of the cotyledon emblica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P31/18A61K127/00
CPCA61K36/47A61K2236/19A61K2236/331A61K2236/333A61K2236/37A61K2236/51
Inventor 王捷龙禹苏志恒叶勇梁浩蒋俊俊朱丹刘丽敏韦锦斌许崇摇
Owner PHARMA FACTORY GUANGXI MEDICAL UNIV
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