Water-soluble hemostatic material and preparation method thereof

A hemostatic material, water-soluble technology, applied in medical science, bandages, absorbent pads, etc., can solve problems such as inability to degrade and absorb in vivo, poor hemostatic effect of chitosan, and inability to use small molecular weight chitosan as a hemostatic material, etc., to achieve Good hemostatic performance, strong hemostatic effect, increasing platelet adhesion and thrombus formation
CN102198288AInactive Publication Date: 2011-09-28WEIGAO HLDG +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WEIGAO HLDG
Publication Date
2011-09-28
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a water-soluble hemostatic material and a preparation method thereof, relating to a hemostatic material and a preparation method thereof. The invention solves the defects that the existing chitosan hemostatic material has poor hemostatic performance and can not deal with a larger amount of bleeding. The water-soluble hemostatic material is prepared from oxidized regenerated cellulose, chitosan solution and alkaline alcoholic solution. The preparation method comprises the following steps of: (1) soaking the oxidized regenerated cellulose into the chitosan solution, then carrying out suction filtration for washing with deionized water, and removing the moisture on the surface of the oxidized regenerated fiber loaded with chitosan; (2) putting the oxidized regenerated fiber loaded with chitosan into the alkaline alcoholic solution to be sealed to carry out a neutralization reaction; and (3) flushing with ethanol solution, then flushing with anhydrous ethanol, and drying to obtain the water-soluble hemostatic material. The water-soluble hemostatic material provided by the invention can be used as a hemostatic material.
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Description

Technical field

[0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique

[0002] As a hemostatic material, chitosan has the advantages of promoting blood coagulation, promoting wound healing, absorbing wound exudate, and not easy to synergize. Because the polycation of chitosan is easy to act on the negatively charged groups on the surface of fungal cells, it can change the fluidity and permeability of the cell membrane of pathogenic bacteria, and it can also interfere with DNA replication and transcription, and can block the metabolism of pathogens. Therefore, chitosan has the advantages of inhibiting the growth of bacteria and fungi as a hemostatic material.

[0003] Small molecular weight chitosan cannot be used as a hemostatic material because of its water solubility, while large molecular weight chitosan cannot be degraded and absorbed in the body, so it is currently mainly used as a medical hemostatic dressing (such as chi...

Claims

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