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Antibacterial alginate dressing as well as preparation method and application thereof

A technology of alginate fiber and hydrochloride, which is applied in textiles and papermaking, biochemical fiber processing, medical science and other directions, can solve the problems of potential safety hazards, environmental pollution, difficulty in large-scale application, and high production costs, and achieve no dissolution. The effect of action time, low production cost and excellent washability

Pending Publication Date: 2022-01-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex process and high production cost of covalent bonding, it is difficult to apply on a large scale, and the polyhexamethylene guanidine salt is dissolved in organic solvents during the preparation process, which has potential safety hazards and environmental pollution.

Method used

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  • Antibacterial alginate dressing as well as preparation method and application thereof
  • Antibacterial alginate dressing as well as preparation method and application thereof
  • Antibacterial alginate dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The preparation of embodiment 1 dressing of the present invention

[0040] 1) Take polyhexamethylene biguanide hydrochloride with a degree of polymerization of 6-18, dissolve it in water, and obtain a solution with a mass fraction of 0.01%;

[0041] 2) Take the solution, soak the alginate fiber dressing for 1 min, rinse the dressing with water until there is no free polyhexamethylene biguanide hydrochloride, and dry it.

Embodiment 2

[0042] Embodiment 2 Preparation of dressing of the present invention

[0043] 1) Take polyhexamethyleneguanidine hydrochloride with a degree of polymerization of 50-100, add water to dissolve, and obtain a solution with a mass fraction of 1%;

[0044] 2) Take the solution, at 0.5mL / cm 2 The amount of the alginate fiber dressing is sprayed, and then the dressing is rinsed with water until there is no free polyhexamethylene biguanide hydrochloride, and then dried.

Embodiment 3

[0045] The preparation of embodiment 3 dressing of the present invention

[0046] 1) Take polyhexamethyleneguanidine hydrochloride with a degree of polymerization of 50-100, add water to dissolve, and obtain a solution with a mass fraction of 2%;

[0047] 2) Take the solution, soak the alginate non-woven fabric for 30 minutes, rinse the non-woven fabric with water until there is no free polyhexamethylene biguanide hydrochloride, and dry it.

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PUM

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Abstract

The invention discloses an alginate fiber dressing. Polymer guanidine and / or salt thereof are / is attached to the alginate fiber dressing through electrostatic interaction. The dressing disclosed by the invention not only has excellent antibacterial performance, but also has good hemostatic performance, is free of dissolution and long in acting time, ensures the safety to human bodies and environments, has excellent washable performance (washable for at least 50 times) and can be repeatedly used, and tests prove that the dressing can be continuously antibacterial for at least 10 cycles. The dressing disclosed by the invention can also be used for products such as face towels, facial masks and the like. The preparation method of the dressing is simple in process, low in production cost and suitable for industrial mass production.

Description

technical field [0001] The invention relates to a medical dressing, in particular to an antibacterial alginate dressing and its preparation method and application. Background technique [0002] As the largest organ of the human body, the skin acts as a barrier against the invasion of pathogens. Once injured, however, it is particularly susceptible to bacterial infection. Bacterial infection-related mortality in burn patients has been reported to be as high as 75%. Therefore, a wound dressing that prevents infection, eliminates excess exudate, and breathes to stop bleeding is an important auxiliary material for treating damaged skin. Wound dressings are essential to wound care, providing a physical barrier between the wound and the external environment to prevent further injury or infection of the wound. However, traditional wound materials have disadvantages such as poor coagulation acceleration effect, potential sensitization, inability to inhibit bacterial infection, la...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/46D06M15/37D06M101/02
CPCA61L15/28A61L15/26A61L15/46D06M15/37D06M16/00D06M2101/02A61L2300/206A61L2300/404C08L5/04C08L79/00
Inventor 谭淋张杰施亦东肖诗梦冯小娟王忠朝
Owner SICHUAN UNIV
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