Chitosan-based nanofiber wound dressing with adhesiveness and antibacterial property and preparation method of chitosan-based nanofiber wound dressing

A nanofiber and wound dressing technology, applied in the field of chitosan-based nanofiber wound dressing and its preparation, can solve the problem of poor hydrophilicity, solubility and tissue adhesion, and unsatisfactory antibacterial performance of drug-resistant bacteria chitosan, etc. problem, to achieve the effect of good water absorption, antibacterial performance promotion, and controlled drug release

Pending Publication Date: 2022-03-25
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrophilicity, solubility and tissue adhesion of chitosan are poor, and the antibacterial properties of chitosan for drug-resistant bacteria are not ideal

Method used

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  • Chitosan-based nanofiber wound dressing with adhesiveness and antibacterial property and preparation method of chitosan-based nanofiber wound dressing
  • Chitosan-based nanofiber wound dressing with adhesiveness and antibacterial property and preparation method of chitosan-based nanofiber wound dressing
  • Chitosan-based nanofiber wound dressing with adhesiveness and antibacterial property and preparation method of chitosan-based nanofiber wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1 gram of polyvinyl alcohol was dissolved in 10 ml of deionized water to obtain a polyvinyl alcohol solution with a concentration of 10% M / V.

[0035] The above polyvinyl alcohol solution was subjected to electrospinning. The conditions of electrospinning were high voltage 15kv, receiving distance 10cm, injector advancing speed 0.3ml / h, drum collector rotating speed 500rpm. After electrospinning, the obtained samples were collected and vacuum-dried More than 12h, save the sample.

Embodiment 2

[0037] 1 gram of polyvinyl alcohol was dissolved in 10 ml of deionized water to obtain a polyvinyl alcohol solution with a concentration of 10% M / V. 0.3 gram of chitosan was dissolved into a volume concentration of 1% V / V acetic acid solution to obtain a concentration of 3% M / V chitosan solution.

[0038] The above-mentioned polyvinyl alcohol solution is used as a shell solution, and the above-mentioned chitosan solution is used as a core solution, and the solutions are injected into corresponding syringes. Carry out coaxial electrospinning, the conditions of electrospinning are high voltage 15kv, receiving distance 10cm, injector advancing speed is 0.3ml / h, drum collector rotating speed 500rpm, after electrospinning, collect the obtained sample, vacuum dry more than 12h, Save the sample.

Embodiment 3

[0040] 1 gram of polyvinyl alcohol was dissolved in 10 ml of deionized water to obtain a polyvinyl alcohol solution with a concentration of 10% M / V. Dissolving 0.3 gram of chitosan into a volume concentration of 1% V / V acetic acid solution to obtain a concentration of 3% M / V chitosan solution, 0.02 gram of dopamine hydrochloride, 0.05 gram of 5-aminolevulinic acid in the shell In the polysaccharide solution, a 5-aminolevulinic acid-dopamine hydrochloride-chitosan solution is obtained. The above-mentioned polyvinyl alcohol solution is used as a shell solution, and the above-mentioned chitosan-dopamine hydrochloride solution is used as a core solution, and the solutions are injected into corresponding syringes. Carry out coaxial electrospinning, the conditions of electrospinning are high voltage 15kv, receiving distance 10cm, injector advancing speed is 0.3ml / h, drum collector rotating speed 500rpm, after electrospinning, collect the obtained sample, vacuum dry more than 12h, S...

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Abstract

The invention provides a chitosan-based nanofiber wound dressing with adhesiveness and antibacterial performance and a preparation method thereof. The chitosan-based nanofiber wound dressing is a core-shell nanofiber, and a nanofiber membrane with the fiber diameter of 100 nm to 20 microns is obtained by conducting electrospinning in a coaxial electrostatic spinning mode. Wherein the polyvinyl alcohol forms a shell of the nanofiber, and the chitosan, the dopamine hydrochloride and the 5-aminolevulinic acid form a core of the nanofiber. Experiments prove that the dopamine hydrochloride and 5-aminolevulinic acid modified chitosan-based nanofiber membrane disclosed by the invention is good in hemostatic performance and has good biocompatibility. The dopamine hydrochloride and the 5-aminolevulinic acid are added into the chitosan solution, so that the good water absorption and the good fiber forming property of polyvinyl alcohol in the original material and the hemostasis property of chitosan are reserved, the adhesion property and the antibacterial property on organism tissues such as skin and organs are improved, and wound healing is promoted.

Description

technical field [0001] The invention relates to a chitosan-based nanofiber wound dressing with adhesion and antibacterial properties and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Traumatic hemorrhage is one of the most common injuries in battlefields and various accident scenes, and uncontrolled bleeding is the primary cause of casualty death at the scene. In fact, most casualties from bleeding were preventable. The more widely used bandage is combat gauze at present, but wound bacterial infection is also a major factor leading to the death of the wounded. At the same time, diabetic patients have severe complications, extremely slow wound closure, high infection rate, resulting in amputation or severed limbs, high medical expenses, and poor quality of life for patients. In order to improve the survival rate of patients, wound dressings also need to be upgraded and improved, and more researches are based on c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/42A61L15/44A61L15/46D04H1/728D04H1/4382
CPCA61L15/28A61L15/24A61L15/20A61L15/42A61L15/44A61L15/46D04H1/728D04H1/43825A61L2300/404A61L2300/236A61L2400/12A61L2300/41A61L2300/412A61L2300/602A61L2400/04C08L5/08C08L29/04
Inventor 胡勇赵清羽金振宇蒋炜黄梦璐
Owner NANJING UNIV
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