Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions
A mesoporous silica and nano-mesoporous technology, applied in biochemical equipment and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve difficult problems, lack of biological activity, etc. problems, to achieve the effect of improved performance, good hemostatic performance, and mild reaction conditions
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[0030] Example 1:
[0031] In the invention, the mesoporous silica nanoparticles are synthesized by a two-phase method, the antibacterial drugs are loaded through the huge specific surface area of the mesoporous silica, encapsulated with dopamine, and the dopamine is used as a drug carrier to load thrombin. The local release of dopamine and thrombin can respectively constrict blood vessels and release coagulation substances, which can achieve synergistic hemostasis, and the antibiotics released at the same time can resist infection, achieve hemostasis and antibacterial. The specific process is as follows:
[0032] (1): Mesoporous silica supported vancomycin:
[0033] (1.1): Synthesis of mesoporous silica nanoparticles: Dissolve 6.0 g CTAC in 60 mL deionized water, heat to 60 °C, and stir to dissolve. Then 100 μL of TEA was added and stirring was continued for 1 hour. Then a 20% by volume solution of TEOS in cyclohexane was added dropwise and the reaction was continued for ...
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