Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof

A technology of alkaneated chitosan and alkylated chitosan, which is applied in the field of medical devices, can solve problems such as poor biocompatibility, non-degradability, and poor air permeability, and achieve good cell biocompatibility, diversified use methods, Promote the effect of wound repair

Inactive Publication Date: 2019-06-11
中国人民解放军东部战区总医院
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  • Abstract
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Problems solved by technology

[0004] 2. Insufficient protective measures for exposed wounds after abdominal cavity opening
In the field of open abdominal cavity treatment, it is improved to cover a layer of plastic or silicone film on the surface of the exposed intestine to avoid direct contact between the sponge in the negative pressure device and the intestine, but due to its poor biocompatibilit

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  • Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof
  • Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof
  • Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof

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[0041] Example 1

[0042] A preparation method of alkaneated chitosan multifunctional hydrogel, comprising the following steps:

[0043] (1) Preparation of synthetic alkaneated chitosan: first prepare 1 g of chitosan (Mw: 4×10 5 ) was dissolved in 50mL 0.2M acetic acid solution, and then added lauryl aldehyde: alkane chitosan molar ratio of 0.05: 1 lauryl aldehyde and sodium hydroborohydride: alkane chitosan molar ratio of 3: 1 hydroboryl Sodium hydride, the pH of the mixed solution was adjusted to 5.01, stirred at room temperature for 18 hours, and then added dropwise with sodium hydroxide to adjust the pH to 7.0, the alkanized chitosan was precipitated, precipitated and filtered, washed with a gradient of ethanol solution with a concentration of 70%-100%, and the product was frozen Dry.

[0044] (2) Preparation of four-armed polyethylene glycol benzaldehyde: 0.978 g of aminated four-armed polyethylene glycol (Mw: 20000) and 0.978 g of 4-p-carboxybenzaldehyde were dissolved...

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Abstract

The invention discloses an alkylated chitosan multifunctional hydrogel as well as a preparation method and application thereof. The preparation method of the alkylated chitosan multifunctional hydrogel comprises the following steps: (1) preparing alkylated chitosan; (2) preparing an alkylated chitosan solution, and preparing a four-arm polyethylene glycol benzaldehyde solution; and (3) mixing thealkylated chitosan solution and the four-arm polyethylene glycol benzaldehyde solution, and performing gelatinization at room temperature. According to the method provided by the invention, an alkanechain is used to modify an amino group of chitosan to prepare the alkylated chitosan, the hydrophobic alkane chain and a hydrophobic cell membrane can be fixed to each other by hydrophobic interaction, so that blood cells can be fixed on the long chain of the chitosan, blood is coagulated, and bleeding is quickly stopped; and polyethylene glycol benzaldehyde is cross-linked through an imine bond to form the stronger-functional more-stable self-repairing hydrogel, and the hydrogel has the functions of concentrating the blood to stop bleeding, absorbing exudate, and promoting wound repair of a hydrogel.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to an alkaneated chitosan multifunctional hydrogel and its preparation method and application, in particular to an alkaneated chitosan multifunctional hydrogel and its preparation method and application. Background technique [0002] 1. Open abdominal therapy is an important means of critical illness treatment [0003] Open abdominal therapy refers to the method of actively opening the abdominal cavity in the treatment of critical patients or closing the abdominal cavity with temporary closure materials without suturing the incision after abdominal surgery. Complications such as external fistula can be divided into three stages, which are early open and temporary abdominal closure stage, mid-term maintenance stage, and late digestive tract and abdominal wall reconstruction stage. This therapy implements the concept of damage control, and has become an important clinical treatment for s...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L71/02C08J3/075C08B37/08C08G65/331A61L26/00
Inventor 任建安陈国璞吴秀文王革非顾国胜
Owner 中国人民解放军东部战区总医院
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