Positively charged bio-fiber hemostatic and antibacterial material as well as preparation method and application thereof

A bio-fiber, positively charged technology, applied in the field of medical materials, can solve the problems of unsatisfactory properties such as moisture absorption, antibacterial, and hemostasis, unsatisfactory hemostatic function and antibacterial function, and unsatisfactory dressing effect. Excellent hemostatic properties, promoting wound healing, and promoting wound healing

Pending Publication Date: 2020-07-28
青岛博益特生物材料股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, along with the research and clinical application, it is found that the dressing effect prepared by pure chitosan is not ideal, and its moisture absorption, antibacterial, hemostatic and other properties cannot meet the needs of more serious skin wound treatment.
Some researchers use chitosan in combination with other materials, such as chitosan and coagulation factors or sodium alginate or collagen or antibacterial agents to improve the performance of dressings, but in fact there are still hemostatic functions, antibacterial functions, and Unsatisfactory problems such as wound surface adhesion, so there is no ideal multifunctional dressing to meet clinical needs

Method used

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  • Positively charged bio-fiber hemostatic and antibacterial material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of biopolysaccharide quaternary ammonium salt.

[0024] Weigh 160g of biological polysaccharide chitosan powder and place it in a stainless steel bucket, add 500ml of NaOH aqueous solution with a concentration of 10% (w / v) as an alkalization solution, stir evenly, alkalize at room temperature for 2hr, and then at -40℃ Alkalinize under the conditions of 12 hr, take it out and thaw it at room temperature, squeeze out the excess lye with filter cloth, wash with water to pH8-9, separate the solid and liquid to obtain alkalized chitosan; install a reflux round bottom flask, put in the flask Add 1000ml of 70% (v / v) acetone aqueous solution as the reaction medium, add alkalized chitosan, stir well, add the reaction reagent 3-chloro-2-hydroxypropyltrimethylammonium chloride 600g, at 40°C Reflux, stirring and reacting for 12 hr; after the reaction, the solid was separated from the liquid to obtain a solid, and the solid was washed with 70% acetone aqueo...

Embodiment 2

[0026] Embodiment 2: Preparation 1 of biopolysaccharide quaternary ammonium salt fiber.

[0027] Weigh 120g of chitosan quaternary ammonium salt (substitution degree 88.2%), put it in a clean stainless steel container, add 2000ml of deionized water, stir and dissolve at room temperature, let it stand to form a viscous colloidal solution, press filter with a filter, Remove a small amount of insoluble matter, and degas the filtrate under vacuum conditions to obtain a 6% (w / v) colloidal solution of quaternary ammonium salts of biological polysaccharides, which is the spinneret liquid; spray the spinneret liquid into 90% (v / v) through the spinneret / v) in the coagulation bath of acetone aqueous solution, the temperature of the coagulation bath is 8 ~ 12 ℃, and fibers are formed; the fibers are drawn by wire rollers, enter the stretching bath of 90% (v / v) acetone aqueous solution, and are stretched Roller traction and stretching, and then winding and stretching, fiber bundles were ...

Embodiment 3

[0028] Embodiment 3: Preparation 2 of biopolysaccharide quaternary ammonium salt fiber.

[0029] Weigh 20g of biopolysaccharide fiber chitosan fiber and place it in a plastic bottle, add 100ml of KOH aqueous solution with a concentration of 20% (w / v) as an alkalization solution, stir evenly, alkalize at -20°C for 12 hr, take out After thawing at room temperature, squeeze out excess lye with filter cloth, wash with water to pH10, remove excess water, and obtain alkalized chitosan fibers; install a reflux round bottom flask, add 200ml of 75% (v / v) acetone aqueous solution as the reaction medium, add alkalized chitosan fiber, add the reaction reagent 3-chloro-2-hydroxypropyltrimethylammonium chloride 180g under stirring, reflux at 30°C, control the pH to about 9, and stir the reaction 6hr; After the reaction, the solid was separated from the liquid to obtain a solid. The solid was washed to neutrality with 75% aqueous acetone as a washing liquid, dehydrated with acetone, and dri...

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Abstract

The invention discloses a positively charged bio-fiber hemostatic and antibacterial material as well as a preparation method and an application thereof. The material is a non-woven fabric material, aknitted fabric material, a woven fabric material, a machine knitting fabric material, a gauze material, a fiber strip material, a fiber cotton ball material or a fiber flocculent material which is formed by biological fibers containing biological polysaccharide quaternary ammonium salt. The positively charged bio-fiber hemostatic and antibacterial material is applied to preparation of medical materials and functional dressings for rapid hemostasis, sterilization, bacteriostasis and wound healing promotion. The material has the advantages that firstly, the biological polysaccharide quaternary ammonium salt with positive charges has stronger positive charges than primary amino; secondly, the material has a loose fiber structure; and therefore, the material has excellent hemostasis performance and sterilization and bacteriostasis performance, and also has the effect of promoting wound healing. The material is convenient to use and operate clinically, can be used for covering, filling andbinding surgical wounds and traumatic wounds very conveniently, can play the functions of stopping bleeding, inhibiting bacteria and promoting healing at the same time, and can better meet clinical application.

Description

technical field [0001] The invention relates to a medical material, in particular to a positively charged biological fiber hemostatic and antibacterial material and its preparation method and application. Background technique [0002] Skin injuries mainly include traumatic bleeding, skin burns, and skin ulcers. Traumatic hemorrhage is common in traffic accidents, mechanical trauma, war trauma, etc. Hemorrhage is the main cause of traumatic death. Burns are skin injuries caused by flames, hot water, strong acids, strong alkalis, radiation and other injury factors. Severe burns with large areas are life-threatening systemic diseases. Pain, exudate, swelling, electrolyte imbalance, easy to Infection, slow healing, causes great suffering to the patient. Skin ulcers such as diabetic foot, venous ulcers, decubitus ulcers, etc., often occur in diabetic patients, obese patients, long-term bedridden patients, etc. Severe ulcer wounds are in a state of infection for a long time, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46D01F9/00
CPCA61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L2300/236A61L2300/404A61L2300/412A61L2400/04D01F9/00C08L5/08C08L1/02C08L1/284C08L1/286C08L5/04C08L3/02C08L89/00
Inventor 刘万顺韩宝芹王云兵冯伊琳石杰
Owner 青岛博益特生物材料股份有限公司
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