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Method for preparing unsymmetrical compound sponge

A composite sponge and asymmetric technology, applied in the field of the preparation of asymmetric composite sponges, can solve the problems of limited functional properties, limited hemostatic effect, etc., and achieve the effects of convenient clinical use, improved product performance, and strong hemostatic effect.

Inactive Publication Date: 2011-07-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most medical sponges are composite sponges made of a single material. Due to the defects of the material itself, the functional properties of this product are limited to a certain extent.
There are also researchers who mix chitosan and gelatin to make asymmetric sponges or add polyvinyl alcohol on the basis of the two to make asymmetric sponges. The efficacy of these so-called asymmetric sponges basically depends on chitosan and gelatin. limited hemostatic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In the first step, sodium carboxymethylcellulose with a degree of substitution of 1.0 is prepared into a 1% solution with water, chitosan with a degree of deacetylation of 60% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared into a concentration of 1% solution.

[0023] In the second step, the three solutions of sodium carboxymethyl cellulose, gelatin and chitosan were measured in a volume ratio of 1:2:2, and the total volume was maintained at 30 mL.

[0024] The third step is to mix the above three solutions, stir evenly, and let stand to defoam.

[0025] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0026] The fifth step is to put all the above-mentioned sponge products into a 50mL watch glass filled with 0.1% carbodiimide solution by mass percentage, seal it with plastic wrap, place it on a d...

Embodiment 2

[0029] The first step is prepared into a 1% solution of sodium carboxymethylcellulose with a degree of substitution of 0.75 with water, chitosan with a degree of deacetylation of 80% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared into a concentration of 1% solution.

[0030] In the second step, the three solutions of sodium carboxymethyl cellulose, gelatin and chitosan were measured in a volume ratio of 1:0.5:3, and the total volume was maintained at 30 mL.

[0031] The third step is to mix the above three solutions, stir evenly, and let stand to defoam.

[0032] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0033] The fifth step is to put all the above-mentioned sponge products into a 40mL watch glass filled with a carbodiimide solution with a mass percentage of 0.05%, seal it with a plastic wrap, p...

Embodiment 3

[0036] The first step is prepared into a 1% solution of sodium carboxymethylcellulose with a degree of substitution of 1.2 with water, chitosan with a degree of deacetylation of 75% is prepared into a 1% solution with dilute acetic acid, and gelatin is prepared with a concentration of 1% solution.

[0037] In the second step, the three solutions of sodium carboxymethylcellulose, gelatin and chitosan were measured in a ratio of 1:2:1 by volume, and the total volume was maintained at 30 mL.

[0038] The third step is to mix the above three solutions, stir evenly, and let stand to defoam.

[0039] The fourth step is to pour the above solution into a polystyrene film-forming device, pre-freeze at -18°C for 12 hours, and vacuum freeze-dry at -40°C for 24 hours to form a sponge product.

[0040] The fifth step is to put all the above-mentioned sponge products into a 30mL watch glass filled with 0.2% carbodiimide solution by mass percentage, seal it with plastic wrap, place it on a ...

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Abstract

The invention discloses a preparing method for asymmetric compound sponge. The method comprises that: distilled water is used for preparing the sodium carboxymethyl cellulose into liquor with a content of 1 percent; watery acetic acid is used for preparing the chitosan into liquor with a content of 1 percent; warm water is used for preparing glutin into liquor with a content of 1 percent. The sodium carboxymethyl cellulose, glutin and chitosan are measured according to the proportion of the volume ratio: 1:0.5 to 3:0.5 to 3 so as to be stood for froth breaking and then are poured into a molding device for freezing and drying through vacuum so as to get the sponge product; the sponge product is put into a watch glass with carbodiimide liquid so as to be put on a decolor rocking bed after being sealed by using preservative film to be vibrated for 24 hours; then distilled water is added; the opening is sealed again by the preservative film; after that, the watch glass is put on the rocking bed to be rocked for an hour; the operation can be operated for three times. The cross bonding treated sponge is treated by secondarily freezing and drying to get the asymmetric compound sponge. The product prepared by the invention is strong in stanching effect and convenient in clinical use, which has favorable sopping moisture retention and drug-loading performance.

Description

technical field [0001] The invention relates to a preparation method of an asymmetrical composite sponge, in particular to mixing carboxymethyl cellulose, chitosan and gelatin by a freeze-drying method to prepare a sponge product with porous, elastic, hemostatic and drug-loading functions. Background technique [0002] After debridement of large-area skin injuries caused by burns and ulcers, skin grafting or artificial skin is required to cover the wound surface to prevent the loss of electrolytes and proteins caused by the loss of tissue fluid and body fluid, prevent bacterial invasion and cause infection, and promote wound tissue healing. At present, the commonly used artificial skin in clinical practice at home and abroad mainly includes pigskin, collagen membrane or collagen sponge polyurethane membrane. Because pigskin is easy to delaminate with the skin, it has poor compatibility with wound tissue, which is not conducive to the regeneration of epidermal tissue cells; t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/32
Inventor 何小维罗志刚罗发兴扶雄
Owner SOUTH CHINA UNIV OF TECH
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