Hemostatic material

A technology of hemostatic materials and substrates, applied in the field of hemostatic materials, can solve the problem of small promotion of platelet aggregation
CN112823029AActive Publication Date: 2021-05-18TORAY IND INC +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TORAY IND INC
Publication Date
2021-05-18

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Abstract

The purpose of the present invention is to provide a lipid-containing hemostatic material capable of promoting adhesion or agglutination of platelets even without having a protein or a peptide supported thereon, such as GPIb and H12, involved in for adhesion or agglutination of platelets. In order to accomplish said purpose, provided is a hemostatic material (10) provided with a water-insoluble base material (1) and a lipid supported on the surface of the base material (1), wherein the lipid comprises one or more types of anionic lipid.
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Description

technical field

[0001] The present invention relates to hemostatic materials. Background technique

[0002] Platelets play a key role in hemostasis, and adhesion of blood platelets to blood vessels or aggregation of blood platelets are important opportunities for hemostasis. Many attempts have been made to artificially produce simulated platelets (platelet substitutes) in order to compensate for decreased platelet count or platelet dysfunction, or to cope with massive bleeding. As such platelet substitutes, for example, attempts have been made to carry proteins that exist on the surface of platelet membranes and are involved in adhesion to the blood vessel wall or aggregation of platelets, proteins that mediate the aggregation of platelets, or as these Lipid microparticles of peptides in active sites of proteins. The key role of platelet adhesion or aggregation is the glycoprotein GPIb present on the membrane surface and the von Willebrand factor (vWF) line as a plasma pro...

Claims

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