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Chitosan alginate dressing and freeze-drying preparation method thereof

A technology of chitosan alginate and chitosan, applied in pharmaceutical formulation, application, medical science and other directions, can solve problems such as cytotoxicity, achieve the effect of simple material, promote wound healing, and maintain a moist environment

Inactive Publication Date: 2016-11-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dressings all have certain cytotoxicity (Rattanaruengsrikul V, PimphaN, Supaphol P. Development of Gelatin Hydrogel Pads as Antibacterial Wound Dressings[J]. Macromolecular Bioscience, 2009, 9(10): 1004–15), and the silver component is not only antibacterial In addition, there is no other obvious function of promoting wound healing

Method used

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  • Chitosan alginate dressing and freeze-drying preparation method thereof
  • Chitosan alginate dressing and freeze-drying preparation method thereof
  • Chitosan alginate dressing and freeze-drying preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The making of embodiment 1 novel chitosan alginate dressing

[0019] 1.5g high molecular weight chitosan (molecular weight is 800,000), 1.5g low molecular weight chitosan (molecular weight is 3 thousand) is added in 97g weakly acidic solution, makes 3% chitosan mixed solution after stirring; Add 3g of sodium alginate to 97g of deionized water, and mix with a magnetic stirrer to obtain a sodium alginate solution with a mass concentration of 3%; the chitosan mixed solution and the sodium alginate solution are blended at a volume ratio of 3:7, and Add glycerol as a plasticizer according to 10% of the volume of the blend solution, stir and mix at a high speed with a homogenizer to obtain a chitosan-sodium alginate mixture; pour the chitosan-sodium alginate mixture into a six-hole plate or culture dish, freeze-dried for 12 hours to obtain a freeze-dried film; the freeze-dried film was placed in 5% CaCl 2 The solution was soaked and cross-linked for 1 hour, rinsed with disti...

Embodiment 2

[0020] The making of embodiment 2 novel chitosan alginate dressings

[0021]1.5g high molecular weight chitosan (molecular weight is 800,000), 1.5g low molecular weight chitosan (molecular weight is 3 thousand) is added in 97g weakly acidic solution, makes 3% chitosan mixed solution after stirring; Add 3g of sodium alginate to 97g of deionized water, and mix with a magnetic stirrer to obtain a sodium alginate solution with a mass concentration of 3%; the chitosan mixed solution and the sodium alginate solution are blended at a volume ratio of 5:5, and Add glycerol as a plasticizer according to 10% of the volume of the blend solution, stir and mix at a high speed with a homogenizer to obtain a chitosan-sodium alginate mixture; pour the chitosan-sodium alginate mixture into a six-hole plate or culture dish, freeze-dried for 18 hours to obtain a freeze-dried film; the freeze-dried film was placed in 5% CaCl 2 The solution was soaked and cross-linked for 1 h, rinsed with distille...

Embodiment 3

[0022] The making of embodiment 3 novel chitosan alginate dressings

[0023] 1.5g high molecular weight chitosan (molecular weight is 800,000), 1.5g low molecular weight chitosan (molecular weight is 3 thousand) is added in 97g weakly acidic solution, makes 3% chitosan mixed solution after stirring; 3g of sodium alginate was added to 97g of deionized water, and mixed with a magnetic stirrer to obtain a sodium alginate solution with a mass concentration of 3%; the chitosan mixed solution and the sodium alginate solution were blended in a volume ratio of 7:3, and Add glycerol as a plasticizer according to 10% of the volume of the blend solution, stir and mix at a high speed with a homogenizer to obtain a chitosan-sodium alginate mixture; pour the chitosan-sodium alginate mixture into a six-hole plate or culture dish, freeze-dried for 24 hours to obtain a lyophilized film; the lyophilized film was placed in 5% CaCl 2 The solution was soaked and cross-linked for 1 hour, rinsed wi...

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Abstract

The invention provides a chitosan alginate dressing. A freeze-drying preparation method for the chitosan alginate dressing comprises the following steps: dissolving a chitosan mixture in an acid solution to prepare a mixed chitosan solution; dissolving sodium alginate in deionized water to prepare a sodium alginate solution; then blending the two solutions; adding glycerol to obtain a chitosan-sodium alginate mixed solution; subjecting the chitosan-sodium alginate mixed solution to freezing and pump drying so as to obtain a freeze-dried film; and soaking the freeze-dried film in a CaCl2 solution for crosslinking, flushing the freeze-dried film with distilled water and carrying out pump drying so as to obtain the novel chitosan alginate dressing. The novel medical dressing is prepared on the basis of the advantages of both chitosan and alginate, has pharmacological effect as chitosan, is capable of resisting bacteria, retaining moisture, stopping bleeding, promoting wound healing and reducing formation of scars, and exerts substantial antibacterial effect except the original haemostatic, moisture-absorbing and moisture-retaining effect of an alginate dressing. The raw materials of the chitosan alginate dressing are widely available; preparation cost is low; and the chitosan alginate dressing is widely applicable to wound treatment.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a chitosan alginate dressing and a freeze-drying preparation method thereof. Background technique [0002] In the early 1960s, British scientist Winter (Winter G D. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. [J]. Rev.ciênc.agron,1995,4(8): 293-4) put forward the theory of moist wound healing through animal wound comparison experiments, that is, the healing effect of wounds in a moist environment is better than that in an open dry environment. The emergence of this theory has led to the development, production and application of a number of wet dressings, including alginate dressings (Zhao Lin, Song Jianxing. Research status and progress of wound dressings [J]. Chinese Tissue Engineering Research and Clinical Rehabilitation, 2007 , 11(9):1724-6). [0003] The raw material of alginate dressing is a kind of cel...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/08
CPCA61L24/0015A61L24/08A61L26/0023A61L26/0066A61L2300/232A61L2300/404A61L2300/412A61L2300/418A61L2400/04C08L5/08C08L5/04
Inventor 谈伟强张利云王晓维方青青徐骥华
Owner ZHEJIANG UNIV
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