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Preparation method of soft hygroscopic composite alginate dressing

A compound alginate and soft technology, which is applied in the field of preparation of compound alginate dressings, can solve the problems of hardness and brittleness, low strength, and unsatisfactory moisture absorption performance, and achieve stability, enhance flexibility, The effect of enhancing the effect

Inactive Publication Date: 2017-06-27
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure alginate fiber is relatively hard and brittle, and its strength is low. According to the feedback of clinical application results, its hygroscopicity cannot be well satisfied for wounds with more exudate.

Method used

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  • Preparation method of soft hygroscopic composite alginate dressing
  • Preparation method of soft hygroscopic composite alginate dressing
  • Preparation method of soft hygroscopic composite alginate dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Configure an aqueous solution of carboxymethyl chitosan with a mass fraction of 1%, which is designated as liquid A; configure a 5% aqueous solution of sodium alginate, which is designated as liquid B; configure a mass fraction of 0.5%, and the solutes are glutaraldehyde and The aqueous solution of genipin mixed according to the weight ratio of 1:2 is recorded as crosslinking agent C liquid.

[0019] (2) Mix liquid A and liquid B at a weight ratio of 1:3 in a hot water bath at 50°C. After stirring evenly, add a certain amount of liquid C so that the concentration of the crosslinking agent in the entire mixed liquid system is 0.6mmol / L, stir quickly, and heat at the same water bath temperature for 1 hour to fully react to obtain crosslinked carboxymethyl chitosan / sodium alginate mixed solution D.

[0020] (3) Add 30% propylene glycol alginate with the weight of liquid D, stir and mix thoroughly in a hot water bath at 50°C to obtain spinning dope E liquid.

[0021] (...

Embodiment 2

[0025] (1) Configure an aqueous solution of carboxymethyl chitosan with a mass fraction of 10%, which is designated as liquid A; configure a 10% aqueous solution of sodium alginate, which is designated as liquid B; configure a mass fraction of 0.1%, and a weight ratio of 1: 4 The mixed solution of glutaraldehyde and genipin is recorded as crosslinking agent C solution.

[0026] (2) Mix liquid A and liquid B at a ratio of 1:2 by weight in a hot water bath at 40°C. After stirring evenly, add a certain amount of liquid C so that the concentration of the crosslinking agent in the entire mixed liquid system is 0.5mmol / L, stir quickly, and heat at the same water bath temperature for 2 hours to fully react to obtain cross-linked carboxymethyl chitosan / sodium alginate mixed solution D.

[0027] (3) Add 20% propylene glycol alginate with the weight of liquid D, stir and mix thoroughly in a hot water bath at 40°C to obtain spinning dope E liquid.

[0028] (4) Spinning: The spinning sto...

Embodiment 3

[0032] (1) Configure an aqueous solution of carboxymethyl chitosan with a mass fraction of 5%, which is designated as liquid A; configure a 6% aqueous solution of sodium alginate, which is designated as liquid B; configure a mass fraction of 0.6%, and a weight ratio of 1: The mixed solution of glutaraldehyde and genipin in 3 is recorded as crosslinking agent C solution.

[0033] (2) Mix liquid A and liquid B at a ratio of 2:3 by weight in a hot water bath at 60°C. After stirring evenly, add a certain amount of liquid C so that the concentration of the crosslinking agent in the entire mixed liquid system is 1mmol / L, stir quickly, and heat at the same water bath temperature for 3 hours to fully react to obtain cross-linked carboxymethyl chitosan / sodium alginate mixed liquid D.

[0034] (3) Add 5% propylene glycol alginate with the weight of liquid D, stir and mix thoroughly in a hot water bath at 60°C to obtain spinning stock solution E.

[0035] (4) Spinning: The spinning stoc...

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Abstract

The invention discloses a preparation method of a soft hygroscopic composite alginate dressing. The preparation method includes: subjecting sodium alginate extracted from brown seaweed and carboxymethyl chitosan to cross-linking modification to form carboxymethyl chitosan / sodium alginate mixed liquid; adding propylene glycol alginate, stirring, and mixing well to form wet-process spinning dope; taking calcium chloride solution as solidification liquid for first solidification bath and one of zinc chloride solution, magnesium chloride solution and copper chloride solution as solidification liquid for second solidification bath for wet-spinning to obtain fiber; subjecting the fiber to needle-punched nonwoven cloth processing, slitting, packaging and sterilizing processes to obtain the soft hygroscopic composite alginate dressing. The alginate dressing prepared by the method has functions of absorbing liquid, maintaining moisture, resisting bacteria and stopping bleeding; due to spatial effect of carboxymethyl in the dressing, acting force among fiber macromolecules is weakened, so that flexibility of the fiber is enhanced, personalized needs of patients on the dressing are met better, and the alginate dressing has good application prospect.

Description

technical field [0001] The invention relates to the technical field of medical consumables, and specifically includes a preparation method of a soft and hygroscopic composite alginate dressing. Background technique [0002] Alginate, also known as algin and alginic acid, is an anionic polysaccharide widely distributed in the cell wall of brown algae, which forms a viscous colloid by combining with water. Alginate is extracted from natural brown seaweed and subsequently converted to sodium or calcium alginate. Alginate dressings can be made using woven or non-woven techniques and look similar to cotton. When it is placed on the wound bed, it can react with wound exudate to form a jelly, creating a moist healing environment. In addition, it can "trap" bacteria to purify the wound bed. When changing the dressing, the gel-like dressing can be easily removed, and the residue can also be washed with normal saline. [0003] Alginate can be processed into alginate fiber by wet sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/18D01F1/10D01F11/00A61L15/28A61L15/42A61L15/44A61L15/46
CPCD01F8/18A61L15/28A61L15/42A61L15/44A61L15/46A61L2300/232A61L2300/402A61L2300/404D01F1/10D01F11/00C08L5/04C08L5/08
Inventor 卢亢陈锦涛熊亮
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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