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Chitosan alginate dressing and soaking preparation method thereof

A technology of chitosan alginate and chitosan, which is used in medical science, absorbent pads, bandages, etc., can solve problems such as cytotoxicity, achieve good biocompatibility, hemostasis wound healing, and increase antibacterial properties.

Inactive Publication Date: 2016-11-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These dressings all have certain cytotoxicity (Rattanaruengsrikul V, PimphaN, Supaphol P. Development of Gelatin Hydrogel Pads as Antibacterial Wound Dressings[J]. Macromolecular Bioscience, 2009, 9(10): 1004–15), and the silver component is not only antibacterial In addition, there is no other obvious function of promoting wound healing

Method used

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  • Chitosan alginate dressing and soaking preparation method thereof
  • Chitosan alginate dressing and soaking preparation method thereof
  • Chitosan alginate dressing and soaking preparation method thereof

Examples

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Effect test

Embodiment 1

[0021] Embodiment 1 The making of novel chitosan alginate dressing

[0022] 7.5g high molecular weight chitosan (molecular weight is 800,000), 7.5g low molecular weight chitosan (molecular weight is 3,000) is added in 85g weakly acidic solution, makes 15% chitosan mixed solution after stirring; The commercialized alginate dressing was immersed in the chitosan solution for 1 hour, took out the dressing, dried in a drying oven at 60° C. for 30 minutes, and sterilized by ultraviolet light for 30 minutes to obtain 15% novel chitosan alginate dressing ( figure 1 ).

Embodiment 2

[0023] Embodiment 2 The making of novel chitosan alginate dressing

[0024] 5.0g high molecular weight chitosan (molecular weight is 800,000), 5.0g low molecular weight chitosan (molecular weight is 3 thousand) is added in 90g weakly acidic solution, makes 10% chitosan mixed liquor after stirring; The commercial alginate dressing was immersed in the chitosan solution for 15 minutes, the dressing was taken out, dried in a freeze dryer for 12 hours, and then sterilized by ultraviolet light for 30 minutes to obtain a 10% novel chitosan alginate dressing.

Embodiment 3

[0025] Embodiment 3 The making of novel chitosan alginate dressing

[0026] 10.0g high molecular weight chitosan (molecular weight is 800,000), 10.0g low molecular weight chitosan (molecular weight is 3 thousand) is added in 80g weakly acidic solution, after stirring, make 20% chitosan mixed liquor; The commercial alginate dressing was immersed in the chitosan solution for 2 hours, the dressing was taken out, dried in a drying oven at 60° C. for 1 hour, and then sterilized by ultraviolet light for 30 minutes to obtain a new 20% chitosan alginate dressing.

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Abstract

The invention provides chitosan alginate dressing. The chitosan alginate dressing is prepared by dissolving a chitosan mixture into a weak acidic solution to prepare a chitosan mixed solution, then soaking commercial alginate dressing into the chitosan mixed solution, and then preparing the chitosan alginate dressing. The chitosan alginate dressing integrates the advantages of chitosan and the conventional alginate dressing, so that the bleeding stop, moisture absorption and retaining properties of the alginate dressing are enhanced, and the chitosan alginate dressing has the properties of resisting bacteria, promoting wound healing and the like. The product has no obvious toxicity to a human body; the raw materials are rich, and the preparation cost is low; the chitosan alginate dressing can be widely applied to wound treatment.

Description

technical field [0001] The invention belongs to the field of medical dressings, and in particular relates to a chitosan alginate dressing and a preparation method for dipping the same. Background technique [0002] In the early 1960s, British scientist Winter (Winter G D. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. [J]. Rev.ciênc.agron,1995,4(8): 293-4) put forward the theory of moist wound healing through animal wound comparison experiments, that is, the healing effect of wounds in a moist environment is better than that in an open dry environment. The emergence of this theory has led to the development, production and application of a number of wet dressings, including alginate dressings (Zhao Lin, Song Jianxing. Research status and progress of wound dressings [J]. Chinese Tissue Engineering Research and Clinical Rehabilitation, 2007 , 11(9):1724-6). [0003] The raw material of alginate dressing is a ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/46A61L15/44A61L15/42
CPCA61L26/0052A61L26/0061A61L26/0066A61L2300/232A61L2300/404A61L2300/412A61L2300/418A61L2300/602C08L5/08C08L5/04
Inventor 谈伟强张利云王晓维方青青徐骥华
Owner ZHEJIANG UNIV
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