Preparation method of alginate dressing for stopping bleeding

An alginate and diatomite technology, which is applied in the field of preparation of hemostatic alginate dressings, can solve the problems of slowing down the wound healing speed, secondary infection, poor hemostatic effect, etc.

Inactive Publication Date: 2015-08-19
傅兴琴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, during use, the existing dressings have poor hemostatic effect, slow down wound healing, and easily cause secondary infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of hemostatic alginate dressing, comprising the following steps:

[0023] (1) In parts by weight, 56 parts of sodium alginate and 17 parts of pectin were placed in a mixer, and the mixer speed was 500 r / min, and heated to 55°C to obtain mixture 1;

[0024] (2) Mix 13 parts of diatomaceous earth, 5 parts of sodium pyrophosphate and 11 parts of sodium polyacrylate, heat to 80°C, keep the temperature for 50 minutes, cool, and sieve to obtain mixture 2 with a particle size of 110 meshes;

[0025] (3) Add mixture 2 to mixture 1, then add 5 parts of sorbitol, 17 parts of hyaluronic acid, 9 parts of aminocaproic acid and 6 parts of linoleic acid, stir evenly at room temperature at a speed of 700 r / min, and use mass Fraction is that the sodium hydroxide solution of 30% adjusts pH to 6-8, obtains mixture three;

[0026] (4) Soak the degreased gauze in the mixture 3 for 130min, place it in a dryer for drying, wherein the dryer temperature is set to 80°C, and...

Embodiment 2

[0028] A preparation method of hemostatic alginate dressing, comprising the following steps:

[0029] (1) In parts by weight, 68 parts of calcium alginate and 21 parts of pectin were placed in a mixer, and the mixer speed was 700 r / min, and heated to 75° C. to obtain mixture 1;

[0030] (2) Mix 18 parts of diatomaceous earth, 12 parts of sodium pyrophosphate and 25 parts of sodium polyacrylate, heat to 100°C, keep the temperature for 60 minutes, cool, and sieve to obtain mixture 2 with a particle size of 140 meshes;

[0031] (3) Add mixture 2 to mixture 1, then add 7 parts of sorbitol, 22 parts of hyaluronic acid, 15 parts of aminocaproic acid and 20 parts of linoleic acid, stir evenly at room temperature at a speed of 850 r / min, and use the mass fraction Adjust pH to 6-8 for 30% sodium hydroxide solution to obtain mixture three;

[0032] (4) Soak the degreased gauze in the mixture 3 for 145 minutes, and place it in a dryer for drying, wherein the temperature of the dryer is ...

Embodiment 3

[0034] A preparation method of hemostatic alginate dressing, comprising the following steps:

[0035] (1) In parts by weight, 54 parts of sodium alginate and 15 parts of pectin were placed in a mixer, and the speed of the mixer was 400 r / min, and heated to 50°C to obtain mixture 1;

[0036] (2) Mix 12 parts of diatomaceous earth, 2 parts of sodium pyrophosphate and 7 parts of sodium polyacrylate, heat to 70°C, keep the temperature for 40 minutes, cool, and sieve to obtain mixture 2 with a particle size of 100 meshes;

[0037] (3) Add mixture 2 to mixture 1, then add 4 parts of sorbitol, 13 parts of hyaluronic acid, 7 parts of aminocaproic acid and 3 parts of linoleic acid, stir evenly at room temperature at a speed of 600 r / min, and use the mass fraction Adjust pH to 6-8 for 30% sodium hydroxide solution to obtain mixture three;

[0038] (4) Soak the degreased gauze in the mixture 3 for 120min, place it in a dryer for drying, wherein the dryer temperature is set to 70°C, and ...

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Abstract

The invention discloses a preparation method of an alginate dressing for stopping bleeding. The preparation method comprises the following steps of placing alginate and pectin into a stirrer according to the part weight, and heating to obtain a mixture I; mixing diatomite, sodium pyrophosphate and sodium polyacrylate, then, heating, preserving heat, cooling and sieving to obtain a mixture II; adding the mixture II into the mixture I, then, adding sorbitol, hyaluronic acid, aminohexanoic acid and linoleic acid, and regulating the pH value after uniformly stirring at room temperature to obtain a mixture III; and soaking absorbent gauze into the mixture III, drying, sealing, packaging and irradiating to obtain the alginate dressing. The dressing prepared by using the preparation method not only has a bacterium inhibiting effect, but also can achieve a bleeding stopping effect so as to be widely applied to clinical treatment.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a preparation method of a hemostatic alginate dressing. Background technique [0002] Dressing refers to the auxiliary materials used in addition to the main material of the article. An important function of modern wound dressing is that it replaces the important function of damaged skin and continues to heal the wound and skin lesions. It protects against mechanical factors (e.g. dirt, impact, inflammation, etc.), against pollution and chemical stimuli; against secondary infection; against desiccation and loss of body fluids (electrolyte loss); against heat loss; actively affects the wound healing process through debridement, Create a microenvironment that promotes wound healing. [0003] However, the existing dressings have poor hemostatic effect during use, slow down the wound healing speed, and easily cause secondary infection. Contents of the invention [0004] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61L15/28A61L15/18A61L15/24A61L15/20
Inventor 傅兴琴
Owner 傅兴琴
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