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A kind of alginate dressing for treating decubitus and preparation method thereof

A technology of alginate and sodium alginate, applied in medical science, absorbent pads, bandages, etc.

Active Publication Date: 2017-11-24
HENAN YADU IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are very few high-end dressings for the treatment of bedsores with independent intellectual property rights in the Chinese market, but they can comprehensively consider maintaining the microenvironment of bedsore wounds moist, oxygen and moisture, adopt high-efficiency antibacterial and anti-infection, and further consider the application to accelerate wound healing. The materials used to prepare modern bed sore dressings are almost blank

Method used

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  • A kind of alginate dressing for treating decubitus and preparation method thereof
  • A kind of alginate dressing for treating decubitus and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0067] 2. If figure 1 , figure 2Shown is an alginate medical dressing for treating decubitus. The dressing has a double-layer composite structure, that is, it is composed of a bottom layer and a top layer. The bottom layer is an alginate composite film layer 2 and the top layer is a natural rubber film layer 1. The natural rubber film layer 1 is an epoxidized natural rubber material film whose epoxidation degree reaches 30-40%, and the thickness of the film is 0.04-0.1 mm; the alginate composite film layer 2 is made of sodium alginate, sodium polyacrylate , Shark collagen, pig skin collagen, chitosan quaternary ammonium salt, basic fibroblast growth factor (bFGF) several materials to form a fibrous membrane, the thickness of the membrane is 1 to 5 mm; the fibrous membrane is composed of fibers The filaments are superimposed and arranged. The fiber filaments have a core 4 and shell 3 structure, wherein the shell layer is composed of sodium alginate, sodium polyacrylate, shark...

Embodiment 2

[0079] A preparation method for an alginate medical dressing for treating decubitus, comprising the steps of:

[0080] A. Take the dry mixture of shark skin and shark cartilage with a crushing fineness of 50 mesh and a content ratio of 6.4:3.6, add 0.1N / L NaOH solution with a mass of 1:15, soak at 8°C for 5 hours, take out and drain Add 1:10 petroleum ether, soak at 8°C for 12 hours, wash with distilled water and drain; add 1:10 of 3.5% acetic acid solution, stir for 48 hours at 8°C, stirring speed 500rpm, Centrifuge under the condition of 40000 rev / min; take the supernatant and add 1mol / L sodium sulfate, after precipitation, filtration, distilled water washing, add 1:10 3.5% acetic acid solution to dissolve, adopt Guangzhou Chaoyu Membrane Separation Technology Co., Ltd. The supplied ultrafiltration membrane with a molecular weight cut-off of 100kDa is ultrafiltered, and the filtrate is freeze-dried to obtain mixed collagen of shark skin and cartilage, and then dissolved in 2...

Embodiment 3

[0090] A preparation method for an alginate medical dressing for treating decubitus, comprising the steps of:

[0091] A. Take the dry mixture of shark skin and shark cartilage with a crushing fineness of 35 mesh and a ratio of 6:4, add 0.1N / L NaOH solution with a mass of 1:15, soak at 8°C for 5 hours, take out and drain Add 1:10 petroleum ether, soak at 8°C for 12 hours, wash with distilled water and drain; add 1:10 of 3.0% acetic acid solution, stir for 48 hours at 8°C, stirring speed 400rpm, Centrifuge under the condition of 40000 rev / min; take the supernatant and add 1mol / L sodium sulfate, after precipitation, filtration, distilled water washing, add 1:10 3.0% acetic acid solution to dissolve, adopt Guangzhou Chaoyu Membrane Separation Technology Co., Ltd. The supplied ultrafiltration membrane with a molecular weight cut-off of 100kDa is ultrafiltered, and the filtrate is freeze-dried to obtain mixed collagen from shark skin and cartilage, and then dissolved in 2% acetic a...

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Abstract

The invention relates to an alginate dressing for treating bedsores and a preparation method thereof. The dressing has a double-layer composite structure, that is, it is composed of a bottom layer and a surface layer, the bottom layer is an alginate composite film layer, and the surface layer is a natural rubber film layer ; Its preparation method comprises the following steps: A, preparation of shark collagen solution; B, preparation of coaxial electrospinning outer layer solution; C, preparation of coaxial electrospinning core layer solution; D, spinning; E, crosslinking ; F, impregnation; G, preparation of epoxidized natural rubber film; H, composite. The dressing prepared by the invention has good biocompatibility, controllable growth mediation of synthetic biological materials, good hygroscopicity, anti-inflammatory and antibacterial properties, can improve local blood supply of wounds, promote tissue growth, and accelerate wound healing, showing It has good versatility, good porosity, soft and comfortable hand feeling, good compliance, easy to use, and is suitable for use in the field of modern biomedicine, especially in the fields of bedsore treatment and care.

Description

technical field [0001] The invention belongs to the technical field of medical products, and more specifically, the invention relates to an alginate medical dressing for treating bedsores, and also relates to a preparation method of the dressing. Background technique [0002] Bed sores, also known as pressure ulcers or pressure sores, are one of the common complications of internal medicine. They are soft tissue necrosis caused by nerve and blood circulation disorders, local tissue continuous ischemia, and malnutrition. The complex pathological process caused by the effect is a very intractable disease. Once it occurs, the course of treatment is long and it is easy to relapse, which can cause damage from the epidermis to subcutaneous tissue, muscles, and even bones and joints, bringing great pain to patients. , Severe cases can be secondary infection, causing sepsis and leading to death. [0003] In the United States, 4.3% of hospitalized patients have decubitus complicatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/32A61L15/44
Inventor 张正男韩立涛敖宁建
Owner HENAN YADU IND
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