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Flexible and foldable biomembrane and preparation method thereof

A biofilm and flexible technology, applied in the field of medical accessories, can solve problems such as water resistance, infection, and poor elasticity

Pending Publication Date: 2018-11-27
YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen dressings have good biocompatibility, can stop bleeding, promote coagulation, and promote cell division and differentiation, but they are relatively weak in stability, poor in elasticity, brittle, not resistant to water, and are derived from animals, so there is a risk of infection

Method used

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  • Flexible and foldable biomembrane and preparation method thereof
  • Flexible and foldable biomembrane and preparation method thereof
  • Flexible and foldable biomembrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] S1-1 Dissolve polyurethane in chloroform solution to prepare a 15% solution, and use electrospinning technology to spin a membrane with a pore size of 1-15 μm and a thickness of 0.1-0.2 mm, which is a medical polyurethane membrane;

[0053] S1-2 Mix alginate fiber and chitosan powder evenly, evenly coat the medical polyurethane membrane obtained in step S1-1, and dry or air-dry the obtained flexible and foldable biofilm.

Embodiment 2

[0055] S2-1 Dissolve polyurethane in chloroform solution to make a 15% solution, PVP is made into a 15% solution with ethanol, use electrospinning technology to spray, and spin into a 1:1 weight ratio with a pore size of 1-15μm , a medical polyurethane diaphragm with a thickness of 0.05-0.1mm;

[0056] S2-2 Evenly coat the alginate dressing on one side surface of the medical polyurethane diaphragm prepared in step S2-1, and coat a layer of polylysine PU-chitosan derivative chloroform solution on the dressing surface to form this Examples of flexible and foldable biofilms.

Embodiment 3

[0058] S3-1 dissolving polyurethane in chloroform solution to prepare 15% chloroform solution, molding it in a concave-convex mold, heating and volatilizing the solvent to form a medical polyurethane diaphragm;

[0059] S3-2 Prepare sodium alginate and chitosan into a gel, evenly coat the medical polyurethane diaphragm obtained in step S3-1, and dry or air dry to form the flexible and foldable polyurethane cervical membrane of this embodiment biofilm.

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Abstract

The invention provides a flexible and foldable biomembrane and a preparation method thereof. The flexible and foldable biomembrane is composed of an inner layer and an outer layer, wherein the outer layer is a medical polyurethane membrane which can be fragmented after absorbing liquid, the inner layer is a wounded surface covering layer and is composed of, for example, chitosan and derivatives thereof or alginate or the mixture dressings of both the chitosan and the alginate, the inner layer can be separately applied to wounded surface repairing and can be used for bonding treatment medicinesto a medicine carrier absorbing layer before the inner layer is used to achieve a treating effect, wounded surfaces comprises skin, mucous membranes or in vivo tissues, and the biomembrane is particularly suitable for cervical repairing. The flexible and foldable biomembrane is produced to be a mushroom-shaped, a protrusion is arranged in the middle, before the flexible and foldable biomembrane is used, the treating medicines are bonded to the chitosan and the derivatives thereof or the alginate dressings, when the biomembrane is used, a special vaginal clamp or a special pushing tool is usedfor pushing the biomembrane and covering the surface of os uteri, the protrusion is fixed to orificium vaginae, sustained local application of a cervical part is achieved, and the treating effect onchronic cervical diseases of cervical erosion and HPV is improved.

Description

technical field [0001] The invention belongs to the field of medical auxiliary materials, and in particular relates to a flexible and foldable biofilm and a preparation method thereof, which are used for adhesion, drug loading and restoration treatment of skin, mucous membranes and viscera surfaces. Background technique [0002] With the development of material science, more and more biomaterials can be used as dressings. The advantages of biological dressings are mainly good compatibility with the human body, less toxic and side effects, low antigenicity, certain water permeability, can reduce the number of dressing changes on the wound surface, and reduce the density of colonies, which is beneficial to control further infection of the wound surface, and can also effectively reduce neonatal infection. Physical damage to granulation tissue. According to different structures, it can be divided into film type, foam sponge type, gel type and composite type. [0003] The film ...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/28A61L15/44A61L15/42A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L15/26A61L15/28A61L15/42A61L15/44A61L31/042A61L31/06A61L31/14A61L31/16A61L2400/04C08L75/04C08L5/04C08L5/08
Inventor 不公告发明人
Owner YUANRONG BIOLOGICAL PHARMA WUXI CO LTD
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