Polyurethane cervix uterus repairing film and preparation method thereof

A technology of polyurethane film and polyurethane diaphragm, which is applied in the field of medical accessories, can solve the problems of infection, weak stability, water resistance, etc., to enhance the therapeutic effect and ensure the effect of continuous drug administration

Inactive Publication Date: 2018-06-15
SUZHOU NANOCRYSTAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Collagen dressings have good biocompatibility, can stop bleeding, promote coagulation, and promote cell division and differentiation, but they are relatively weak in stability, poor in elasticity, brittle, not resistant to water, and are derived from animals, so there is a risk of infection

Method used

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  • Polyurethane cervix uterus repairing film and preparation method thereof
  • Polyurethane cervix uterus repairing film and preparation method thereof
  • Polyurethane cervix uterus repairing film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] S1-1 Dissolve polyurethane in chloroform solution to make a 15% solution, and use electrospinning technology to spin a diaphragm with a pore size of 10-150 μm and a thickness of 0.1-0.2 mm, which is a medical polyurethane diaphragm;

[0039] S1-2 Apply the sodium hyaluronate gel evenly on the medical polyurethane membrane obtained in step S1-1, and dry or dry the acquired polyurethane cervical repair membrane.

Embodiment 2

[0041] S2-1 Dissolve polyurethane in chloroform solution to make a 15% solution, PVP is made into a 15% solution with ethanol, and use electrospinning technology to spray against each other, spinning into a pore size of 1-150 μm with a weight ratio of 1:1 , a medical polyurethane diaphragm with a thickness of 0.05-0.1mm.

[0042] S2-2 On one side of the medical polyurethane diaphragm prepared in step S2-1, evenly coat a layer of polylysine PU (prepared into 1% hydrogel for later use), which forms the polyurethane cervical repair of this embodiment membrane.

Embodiment 3

[0044] S3-1 Dissolve polyurethane in chloroform solution to make 15% chloroform solution, and use electrospinning technology to spin into a membrane with a porous structure with a pore size of 10-300 μm and a thickness of 0.2-0.3 mm to form medical polyurethane Diaphragm;

[0045] S3-2 Sodium alginate is made into a gel, evenly coated on the medical polyurethane diaphragm obtained in step S3-1, and dried or air-dried to form the polyurethane cervical repair membrane of this embodiment.

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Abstract

The invention provides a polyurethane cervix uterus repairing film which is characterized by being prepared from a medical polyurethane membrane and a membrane conveying device, wherein the membrane conveying device comprises an injector casing, a push rod sealing plug and a push rod; the push rod sealing plug is arranged in the injector casing, the rear end of the push rod sealing plug is fixedlyconnected with the push rod, the rear end of the push rod extends out of the rear end of the injector casing, and a membrane adsorption opening is formed in the front end of the injector casing. Before the polyurethane cervix uterus repairing film is utilized, the medical polyurethane membrane is adsorbed by the membrane adsorption opening; when the polyurethane cervix uterus repairing film is utilized, the membrane conveying device pushes the medical polyurethane membrane to be attached to the surface of the cervix uterus.

Description

technical field [0001] The invention belongs to the field of medical auxiliary materials, and in particular relates to a polyurethane cervical repair membrane and a preparation method thereof, which are used for drug-loaded adhesion repair treatment of cervical parts. Background technique [0002] Cervical diseases mainly include inflammation and HPV virus infection. They are common and frequently-occurring diseases in gynecology. They can cause uterus, fallopian tubes and pelvic inflammatory disease. They are difficult to cure and have a high recurrence rate. Physical isolation combined with appropriate drugs or treatment equipment is currently one of the most effective means One, the typical one is the chitosan cervical membrane, although the chitosan cervical membrane is applied to the cervicitis lesion (columnar epithelial cells on the surface of the cervix and cervical glands), and acts as a biological barrier to the wound and mucous membrane, but Chitin (or chitosan) d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/34A61P15/00
CPCA61K9/0034A61K9/7007A61K47/34
Inventor 不公告发明人
Owner SUZHOU NANOCRYSTAL PHARMA
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