An alginate dressing for treating bedsore and a preparing method thereof
A technology of alginate and sodium alginate, used in medical science, absorbent pads, bandages, etc.
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Embodiment 1
[0067] 2. If figure 1 , figure 2Shown is an alginate medical dressing for treating decubitus. The dressing has a double-layer composite structure, that is, it is composed of a bottom layer and a top layer. The bottom layer is an alginate composite film layer 2 and the top layer is a natural rubber film layer 1. The natural rubber film layer 1 is an epoxidized natural rubber material film whose epoxidation degree reaches 30-40%, and the thickness of the film is 0.04-0.1 mm; the alginate composite film layer 2 is made of sodium alginate, sodium polyacrylate , Shark collagen, pig skin collagen, chitosan quaternary ammonium salt, basic fibroblast growth factor (bFGF) several materials to form a fibrous membrane, the thickness of the membrane is 1 to 5 mm; the fibrous membrane is composed of fibers The filaments are superimposed and arranged. The fiber filaments have a core 4 and shell 3 structure, wherein the shell layer is composed of sodium alginate, sodium polyacrylate, shark...
Embodiment 2
[0079] A preparation method for an alginate medical dressing for treating decubitus, comprising the steps of:
[0080] A. Take the dry mixture of shark skin and shark cartilage with a crushing fineness of 50 mesh and a content ratio of 6.4:3.6, add 0.1N / L NaOH solution with a mass of 1:15, soak at 8°C for 5 hours, take out and drain Add 1:10 petroleum ether, soak at 8°C for 12 hours, wash with distilled water and drain; add 1:10 of 3.5% acetic acid solution, stir for 48 hours at 8°C, stirring speed 500rpm, Centrifuge under the condition of 40000 rev / min; take the supernatant and add 1mol / L sodium sulfate, after precipitation, filtration, distilled water washing, add 1:10 3.5% acetic acid solution to dissolve, adopt Guangzhou Chaoyu Membrane Separation Technology Co., Ltd. The supplied ultrafiltration membrane with a molecular weight cut-off of 100kDa is ultrafiltered, and the filtrate is freeze-dried to obtain mixed collagen of shark skin and cartilage, and then dissolved in 2...
Embodiment 3
[0090] A preparation method for an alginate medical dressing for treating decubitus, comprising the steps of:
[0091] A. Take the dry mixture of shark skin and shark cartilage with a crushing fineness of 35 mesh and a ratio of 6:4, add 0.1N / L NaOH solution with a mass of 1:15, soak at 8°C for 5 hours, take out and drain Add 1:10 petroleum ether, soak at 8°C for 12 hours, wash with distilled water and drain; add 1:10 of 3.0% acetic acid solution, stir for 48 hours at 8°C, stirring speed 400rpm, Centrifuge under the condition of 40000 rev / min; take the supernatant and add 1mol / L sodium sulfate, after precipitation, filtration, distilled water washing, add 1:10 3.0% acetic acid solution to dissolve, adopt Guangzhou Chaoyu Membrane Separation Technology Co., Ltd. The supplied ultrafiltration membrane with a molecular weight cut-off of 100kDa is ultrafiltered, and the filtrate is freeze-dried to obtain mixed collagen from shark skin and cartilage, and then dissolved in 2% acetic a...
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Abstract
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