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Method for preparing high anti-bacterial alginate dressing

An alginate and antibacterial technology, which is applied in the field of preparation of high antibacterial alginate dressings, can solve the problems of easy shedding of nano-ions, insufficient bonding, and decreased antibacterial performance of alginate dressings, and achieve good antibacterial performance , long-lasting antibacterial effect, and the effect of promoting wound healing

Active Publication Date: 2015-05-13
GUANGDONG TAIBAO MEDICAL SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the way of physical compounding is not tightly combined, and chitosan, silver ions, nano ions and other substances with antibacterial function are easy to fall off during the process of packaging, transportation and use, resulting in the decline of antibacterial performance of alginate dressings.

Method used

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  • Method for preparing high anti-bacterial alginate dressing
  • Method for preparing high anti-bacterial alginate dressing
  • Method for preparing high anti-bacterial alginate dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of high antibacterial alginate dressing, the specific steps are as follows:

[0025] (1) Surface activation of alginate fibers: Cut 3.00 g of alginate fibers into short fibers with a length of 3-5 cm, soak them in ethanol for 2 hours, and ultrasonically treat them at 60°C for 20 minutes. Wash with deionized water several times, filter by suction and dry at room temperature;

[0026] (2) Functional modification of alginate fibers: add the surface-activated alginate fibers in step (1) to 100 ml of dimethyl diallyl ammonium chloride, raise the temperature to 50°C, and add 2 ml An aqueous solution of 0.04 g of ferrous ammonium sulfate and 0.8 ml of 30% hydrogen peroxide were added and reacted, and the reaction was stirred for 3 h. After washing with deionized water several times, it was vacuum dried at 50°C to obtain 3.43 g. Alginate fiber;

[0027] (3) Preparation of high antibacterial alginate dressing: the alginate fiber modified in step (2) is dried by a...

Embodiment 2

[0035] A preparation method of high antibacterial alginate dressing, the specific steps are as follows:

[0036] (1) Surface activation of alginate fibers: Cut 3.00 g of alginate fibers into short fibers with a length of 3-5 cm, add methanol to soak for 0.5 h, and ultrasonically treat them at 30°C for 60 minutes. Wash with deionized water several times, filter by suction and dry at room temperature;

[0037] (2) Functional modification of alginate fiber: add the surface activated alginate fiber in step (1) to 100 ml of 3-chloro-2-hydroxypropyltrimethylammonium chloride solution, and heat to 70 ℃, add 2 ml of an aqueous solution of 0.01 g of ferrous ammonium sulfate and 1.0 ml of 30% hydrogen peroxide to the reaction, and stir the reaction for 3 hours, wash with deionized water for several times, and vacuum at 50℃ After drying, 3.27 g of modified alginate fiber was obtained;

[0038] (3) Preparation of high antibacterial alginate dressing: the alginate fiber modified in step (2) is ...

Embodiment 3

[0046] A preparation method of high antibacterial alginate dressing, the specific steps are as follows:

[0047] (1) Surface activation of alginate fibers: Cut 3.00 g of alginate fibers into short fibers with a length of 3-5 cm, soak them in acetone for 1 hour, and ultrasonically treat them at 20°C for 30 minutes. Wash with deionized water several times, filter by suction and dry at room temperature;

[0048] (2) Functional modification of alginate fibers: Add the surface activated alginate fibers in step (1) to 60 ml of methacryloxyethyltrimethylammonium chloride solution, and heat to 30°C. Add 5 ml of an aqueous solution with 0.9 g of cerium ammonium nitrate dissolved in it to react, and stir the reaction for 3 h, wash it with deionized water several times and then vacuum dry at 50°C to obtain 3.55 g of modified alginate fiber;

[0049] (3) Preparation of high antibacterial alginate dressing: the alginate fiber modified in step (2) is dried by acupuncture and hot press; after card...

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Abstract

The invention discloses a method for preparing a high anti-bacterial alginate dressing. The method comprises the following specific steps: (1) surface activation of an alginate fiber: soaking the alginate fiber into an organic solvent medium, carrying out ultrasonic treatment, washing, carrying out suction filtration and airing at a room temperature; (2) functional modification of the alginate fiber: adding the surface-activated alginate fiber to a quaternary ammonium reagent reaction liquid, adding a catalyst to react after warming, ending reaction, and washing and drying with deionized water for a plurality of times; and (3) preparation of the high anti-bacterial alginate dressing: carrying out acupuncture and hot-press drying technologies on the modified alginate fiber, preparing alginate non-woven fabrics by carding, lapping and acupuncture technologies, cutting, packing and sterilizing to obtain the high anti-bacterial alginate dressing. The preparation method disclosed by the invention is simple, and easy to operate; the prepared dressing also has high anti-bacterial property except for excellent performance of the alginate; the using effect of the alginate dressing is improved; and the application field of the alginate dressing is expanded.

Description

Technical field [0001] The invention belongs to the field of functional modification of alginate medical materials, and specifically relates to a preparation method of a highly antibacterial alginate dressing. Background technique [0002] Alginic acid is extracted from brown algae β -1,4-D-mannuronic acid and α -1,4-D-L-Guluronic acid composed of heteropolysaccharides. The application of alginate fiber in medical dressings originated from wet therapy. In 1962, Winter discovered that wounds heal faster in a humid environment than in a dry environment, which changed the traditional theory of wound healing. People began to develop various high-tech dressings. . Studies have shown that alginate functional dressings are a type of dressing made of alginate. It is as soft as gauze, has good applicability, and has strong absorption, which can absorb 20 times its own weight. liquid. The calcium alginate used in the dressing is a non-water-soluble salt. When in contact with the wound, ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44
Inventor 卢亢韦加娜陈锦涛何立彬
Owner GUANGDONG TAIBAO MEDICAL SCI TECH
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