The application discloses a preparation method of amino magnetic beads, which comprises the following steps:
coating a magnetic
nanoparticle with a
silicon shell to form a
silicon magnetic bead; modifying the
silicon magnetic bead to form a modified silicon
magnetic bead; reacting the modified silicon magnetic bead with an organic amine to form an aminated silicon magnetic bead; and performing a
polymerization reaction on the aminated silicon magnetic bead to form the amino magnetic bead. The application forms a dense
polyamide polymer layer on the surface of the magnetic bead core through an amidation
coating scheme, so as to optimize the structure of the
polymer layer of the magnetic bead. The
magnetic response speed of the prepared magnetic bead is relatively fast due to the relatively large proportion of the
magnetic core part of the magnetic bead and the relatively large number of hydrophilic active groups and charges on the surface of the
polymer layer. The prepared magnetic bead has excellent later modification
extensibility due to the adjustable type of the active groups carried on the surface.