Ternary composite microsphere formulation and its preparation method

A technology of composite microspheres and preparations, applied in the field of pharmacy, can solve the problems of activity change and difficulty in improving the encapsulation rate, and achieve the effect of improving the encapsulation rate, good drug release mode, and reducing incomplete release
CN1557283AInactive Publication Date: 2004-12-29ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2004-12-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The triple composite microsphere preparation consists of mainly model medicine, calcium alginate, chitosan, and diglycolide-lactide copolymer. The preparation process includes W / O emulsification, washing with isopropanol to prepare small calcium alginate microcapsule, coating with chitosan to form compact double-layered alginic acid-chitonsan microcapsule, the subsequent emulsifying and solvent volatilization step to coat the double-layered alginic acid-chitonsan microcapsule into diglycolide-lactide copolymer to form the three-layered composite microsphere. The present invention can protect protein and polypeptide medicine in hydrophilic sodium alginate-chitonsan microcapsule environment to reduce abrupt release and incomplete release, prolong the medicine release time, and regulate the medicine releasing mode via altering PLGA composition.
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Description

Technical field

[0001] The invention belongs to the field of pharmacy, and relates to a biodegradable microcapsule and microsphere preparation and a preparation method thereof, in particular to a calcium alginate-chitosan-glycolide-lactide copolymer triple composite microsphere preparation and a preparation method thereof. This new compound preparation is of great significance to solving the bottleneck problem of protein vaccine administration. technical background

[0002] Vaccination is the most effective public health measure against infectious diseases other than the provision of purified water. It’s just that some vaccines such as hepatitis B vaccine and tetanus vaccine often need to be inoculated 2-3 times to achieve the expected immune effect. Therefore, complete immunization upon first vaccination is one of the main goals of the World Health Organization's vaccine development programme. The development of a single-dose vaccine that provides full immunity with a sin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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