33results about How to "Reduce burst phenomenon" patented technology

The invention relates to a compound microsphere for orderly releasing growth factors and antibiotics and its preparation method and application. The PLGA microspheres co-loaded with growth factors and antibiotics are modified by ethylene glycol chitosan, wherein the antibiotics are encapsulated in ethylene glycol. The chitosan shell contains growth factors in the PLGA core; the composite microspheres have an orderly release function, and the antibiotics in the shell are released quickly to achieve rapid anti-inflammatory effects, while the growth factors in the core are slowly released to induce tissue regeneration. The composite microsphere prepared by the invention has high drug encapsulation rate, simple preparation process and easy industrialization; it can be applied to the preparation of carrier materials for repairing diseased and defective periodontal tissue, bone or cartilage tissue.

The invention relates to a phospholipid protein particle composite microsphere and a preparation method thereof. The preparation method comprises the following steps: stirring and mixing protein or polypeptide water-soluble drugs, an aqueous solution of a freeze-drying protective additive and an alcoholic solution of phospholipid to obtain a lipid vesicle suspension of phospholipid protein; freeze-drying for removing the solvent to obtain phospholipid protein particles; uniformly dispersing the phospholipid protein particles into an organic solution of a polymer carrier material, then adding an aqueous solution containing an emulsifying agent, and shearing at a high speed to prepare emulsion of S / O / W; and carrying out the processes of solvent volatilization, microsphere curing and the like to form the phospholipid protein particle composite microsphere. The phospholipid protein particle composite microsphere prepared by the method provided by the invention has a high drug envelopment rate and a low sudden release rate, wherein the release rate at the first day is 9-15%; the release rate is stable and lasting, the slow release period of the preparation can reach 20-60 days, and the bioactivity of the drugs in the microsphere is high; and therefore, the phospholipid protein particle composite microsphere has practical values in clinical application.

The invention provides a composite drug-carrying gel and a preparation method thereof. The preparation method includes the following steps: S1. Add pyrrole and dopamine hydrochloride into water and mix evenly, then add ammonium persulfate, stir and react, and centrifuge and wash to obtain polypyrrole -Polydopamine nanocomposite material; S2, placing the nanocomposite material in a 1mol / L hydrochloric acid solution containing drug molecules and a graphene oxide aqueous solution in turn, and centrifugal adsorption to obtain graphene oxide-polypyrrole-polydopamine nanocomposite drug-loading material; S3. After mixing the nano-composite drug-carrying material with the water-soluble polymer solution, adding calcium chloride solution, stirring, and letting it stand, the composite drug-carrying gel is obtained. The composite drug-carrying material provided by the invention is compounded with a water-soluble polymer, which can promote the formation of the composite drug-carrying gel, slow down the sudden release phenomenon at the initial stage of drug release, and at the same time, the composite drug-carrying gel has multiple stimuli responsiveness.

The invention relates to a method for preparing a small molecule hydrophilic drug-embedded sustained-release capsule. The method comprises the following steps: filtering a prepared'internal aqueous phase / oil phase / external aqueous phase' pre-multi-emulsion solution through a microporous membrane; and then removing a solvent, washing and drying to obtain the small molecule hydrophilic drug-embedded sustained-release capsule, wherein the internal aqueous phase comprises a small molecule hydrophilic drug and a thickening agent. The small molecule hydrophilic drug-embedded sustained-release capsule provided by the invention has the advantages of uniform grain diameter, high embedding rate, low burst-release rate, stable drug release and long action.

The invention discloses a water-soluble drug sustained-release microsphere and a preparation method and applications thereof. The microsphere comprises an inner core area and an outer core dispersing area; the inner core area is formed by using an isolating oil phase to seal the water-soluble drug; the outer core dispersing area is a medical macromolecular accessory. The invention discloses the preparation method for the water-soluble drug sustained-release microsphere; the medical macromolecular accessory is dissolved into an organic solvent to form a dispersing medium; the powder of the water-soluble drug is dispersed into an isolating layer oil phase to form suspension liquid and slowly release into the dispersing medium; then the suspension liquid is prepared into first milk; then thefirst milk is prepared into emulsion. The organic solvent is volatilized to form the microsphere; the suspension liquid dispersed with the microsphere is centrifugated, filtered, washed, dried and collected, thus obtaining the microsphere. The invention also discloses an emulsion-solvent vaporizing method to prepare the water-soluble drug sustained-release microsphere and the applications of the preparation method in different drug preparations. The microsphere preparation technique is stable, and practical; the shape of the microsphere is round; the surface is smooth, the fluidity is good and the granularity distribution is uniform.