Composite drug-loaded gel and preparation method thereof

A gel and drug-carrying technology, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. performance, mitigating burst phenomena, promoting the effect of the formation of

Active Publication Date: 2021-07-30
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the object of the present invention is a composite drug-loaded gel and its preparation method to solve the problem that the existing drug-loaded gel has obvious burst release effect and easily leads to the loss of activity of drug molecules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] The embodiment of the present invention provides a preparation method of a composite drug-loaded gel, comprising the following steps:

[0027] S1, adding pyrrole and dopamine hydrochloride into water and mixing evenly, then adding ammonium persulfate, stirring and reacting, centrifuging and washing to obtain a polypyrrole-polydopamine nanocomposite material;

[0028] S2. The nanocomposite material is sequentially placed in a 1mol / L hydrochloric acid solution containing drug molecules and a graphene oxide aqueous solution, and centrifugally adsorbed to obtain a graphene oxide-polypyrrole-polydopamine nanocomposite drug-loaded material;

[0029] S3. After mixing the nano-composite drug-loaded material with the water-soluble polymer solution, add calcium chloride solution, stir and let stand to obtain a composite drug-loaded gel.

[0030] Specifically, in step S1, the mass ratio of pyrrole, dopamine hydrochloride and ammonium persulfate is 1:(1-2):(1-3), the temperature of...

Embodiment 1

[0043] This embodiment provides a method for preparing a composite drug-loaded gel, which specifically includes the following steps:

[0044] 1) Add 1 mmol of pyrrole and 2 mmol of dopamine hydrochloride to 30 mL of water with pH = 8 and mix evenly, add 3 g of ammonium persulfate to it, stir and react at 4°C for 24 hours, and then centrifugally wash to obtain a polypyrrole-polydopamine nanocomposite Material;

[0045] 2) Place 1mg of polypyrrole-polydopamine nanocomposite in 1mol / L dilute hydrochloric acid containing doxorubicin hydrochloride and graphene oxide aqueous solution for 24 hours, and centrifuge to obtain graphene oxide-polypyrrole-polydopamine nanocomposites. For the composite drug-loading material, the concentration of doxorubicin hydrochloride is 4 mg / mL, the volume of dilute hydrochloric acid is 1 mL, the concentration of graphene oxide is 1 mg / mL, and the volume of graphene oxide solution is 2 mL;

[0046] 3) Mix 1 mg of graphene oxide-polypyrrole-polydopamine...

Embodiment 2

[0049] This embodiment provides a preparation method of a composite drug-loaded gel, which differs from Example 1 in that:

[0050] In step 1), 1 mmol of pyrrole and 2 mmol of dopamine hydrochloride were added to 30 mL of water with pH=9 and mixed uniformly;

[0051] In step 2), 2 mg of polypyrrole-polydopamine nanocomposite material was placed in 1mol / L dilute hydrochloric acid and graphene oxide aqueous solution containing methotrexate in turn for 36 hours, and then centrifugally adsorbed to obtain graphene oxide-polypyrrole-polydopamine Nanocomposite drug-loaded material, the concentration of methotrexate is 0.5mg / mL, the volume of dilute hydrochloric acid is 2mL, the concentration of graphene oxide is 2mg / mL, and the volume of graphene oxide solution is 1mL;

[0052] In step 3), after mixing 2 mg of graphene oxide-polypyrrole-polydopamine nanocomposite drug-loaded material with sodium alginate aqueous solution, add calcium chloride solution, stir and let stand for 36 hours...

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Abstract

The invention provides a composite drug-loaded gel and a preparation method thereof, and the preparation method comprises the following steps: S1, adding pyrrole and dopamine hydrochloride into water, uniformly mixing, then adding ammonium persulfate, carrying out a stirring reaction, and carrying out centrifugal washing to obtain a polypyrrole-polydopamine nano composite material; S2, sequentially putting the nano composite material into a 1mol / L hydrochloric acid solution containing drug molecules and a graphene oxide aqueous solution, and carrying out centrifugal adsorption to obtain a graphene oxide-polypyrrole-polydopamine nano composite drug-loading material; and S3, mixing the nano-composite drug-loading material with a water-soluble polymer solution, adding a calcium chloride solution, stirring, and standing to obtain the composite drug-loading gel. The composite drug-loading material provided by the invention is compounded with a water-soluble polymer, so that the formation of composite drug-loading gel can be promoted, the burst release phenomenon at the initial stage of drug release is slowed down, and meanwhile, the composite drug-loading gel has multiple stimulation responsiveness.

Description

technical field [0001] The invention relates to the technical field of functional polymer composite materials, in particular to a composite drug-loaded gel and a preparation method thereof. Background technique [0002] Gel is a material with a three-dimensional space network structure, which is ubiquitous in people's production and life, and has extensive research and application in the fields of bioengineering and medicine. This material is usually a three-dimensional polymer network formed by polymer chains, capable of absorbing and retaining large amounts of water or biological fluids, while being insoluble in water due to physicochemical crosslinking. Hydrogel materials formed from hydrophilic polymers exhibit thermodynamic compatibility when exposed to water, that is, they can swell in aqueous media, and have been widely used in the fields of controlled drug release, sensors, and tissue engineering. [0003] At present, most gel-loaded drugs are physically encapsulate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/34A61K47/04A61K31/704A61K31/519A61K47/61
CPCA61K9/06A61K47/34A61K47/02A61K31/704A61K31/519A61K47/61
Inventor 杜寒威喻湘华李亮刘辉刘玉兰
Owner WUHAN INSTITUTE OF TECHNOLOGY
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