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Konjac glucomannan sodium alginate composite drug-loaded microsphere as well as preparation method and application thereof

A technology of konjac glucomannan and sodium alginate, which is applied in the direction of pharmaceutical formulations, drug combinations, anti-tumor drugs, etc., to achieve the effect of rich raw materials, good thermal stability, and large specific surface area

Active Publication Date: 2022-06-28
HUBEI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of this, the present invention proposes a compound drug-loaded microsphere of konjac glucomannan sodium alginate and its preparation method and application, to solve or partially solve the problems existing in the prior art

Method used

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  • Konjac glucomannan sodium alginate composite drug-loaded microsphere as well as preparation method and application thereof
  • Konjac glucomannan sodium alginate composite drug-loaded microsphere as well as preparation method and application thereof
  • Konjac glucomannan sodium alginate composite drug-loaded microsphere as well as preparation method and application thereof

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preparation example Construction

[0032] The embodiment of the present application provides a preparation method of konjac glucomannan sodium alginate composite drug-carrying microspheres, comprising the following steps:

[0033] S1, after mixing konjac glucomannan solution and sodium alginate solution, obtain the first mixed solution;

[0034] S2, adding attapulgite to the first mixed solution, stirring evenly, to obtain a second mixed solution;

[0035] S3. Add fluorouracil to the second mixed solution, stir, and then inject the solution into CaCl using a syringe 2 In the solution, microspheres are formed, and then the microspheres are transferred into a glutaraldehyde solution for cross-linking reaction, washed and dried to obtain konjac glucomannan and sodium alginate composite drug-carrying microspheres.

[0036] The preparation method of konjac glucomannan sodium alginate composite drug-carrying microspheres of the present invention adopts the matrix materials all from natural products, and the inorgani...

Embodiment 1

[0065] The embodiment of the present application provides a preparation method of konjac glucomannan sodium alginate composite drug-carrying microspheres, comprising the following steps:

[0066] S1, after mixing the konjac glucomannan solution with a mass concentration of 1% and a sodium alginate solution with a mass concentration of 3%, use a magnetic stirrer to stir for 2h to obtain a first mixed solution; wherein, the konjac glucomannan solution and the seaweed The volume ratio of the sodium solution is 1:9;

[0067] S2, adding 400mg attapulgite to the first mixed solution, stirring evenly, to obtain the second mixed solution;

[0068] S3. Adjust the pH of the second mixed solution to 11 with 0.1 mol / L NaOH solution, stir evenly, then ultrasonicate for 30 minutes, then add 100 mg of fluorouracil and continue to stir for 60 minutes; then use a syringe with an inner diameter of 0.6 mm to make the solution Injected into CaCl with a mass concentration of 2% 2 In the solution...

Embodiment 2

[0074] The embodiment of the present application provides a preparation method of konjac glucomannan sodium alginate composite drug-carrying microspheres, comprising the following steps:

[0075] S1, after mixing the konjac glucomannan solution with a mass concentration of 1% and a sodium alginate solution with a mass concentration of 3%, use a magnetic stirrer to stir for 2h to obtain a first mixed solution; wherein, the konjac glucomannan solution and the seaweed The volume ratio of the sodium solution is 1:9;

[0076] S2, adding 200mg attapulgite to the first mixed solution, stirring evenly, to obtain the second mixed solution;

[0077] S3. Adjust the pH of the second mixed solution to 12 with 0.1mol / L NaOH solution, stir evenly, then ultrasonicate for 30 minutes, then add 150 mg of fluorouracil and continue to stir for 60 minutes; then use a syringe with an inner diameter of 0.6 mm to make the solution Injected into CaCl with a mass concentration of 2% 2 In the solution,...

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Abstract

The invention provides a konjac glucomannan and sodium alginate composite drug-loaded microsphere and a preparation method and application thereof.The preparation method of the composite drug-loaded microsphere comprises the following steps that a konjac glucomannan solution and a sodium alginate solution are mixed, attapulgite is added and stirred, fluorouracil is added and stirred, and the konjac glucomannan and sodium alginate composite drug-loaded microsphere is obtained. And injecting the solution into a CaCl2 solution by using an injector to form microspheres, transferring the microspheres into a glutaraldehyde solution, reacting, washing and drying. The inorganic mineral attapulgite is added into a natural high polymer material to increase the encapsulation and controlled release of the natural high polymer material to drugs, the composite material is prepared by a simple gel method, the encapsulation efficiency of fluorouracil is high, and the burst release phenomenon of 5-FU in a simulated solution can be obviously reduced; the preparation method disclosed by the invention is simple, the raw materials are rich, the thermal stability is good, the biocompatibility is good, the drug encapsulation efficiency is high, and the prepared composite drug-loaded microspheres are obvious in slow-release effect.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to a konjac glucomannan sodium alginate composite drug-carrying microsphere and a preparation method and application thereof. Background technique [0002] Fluorouracil (5-FU) is a hydrophilic anticancer drug commonly used to treat solid breast, colorectal, liver, neck, and brain tumors. It can be used safely in combination with most other chemotherapeutic agents, making it a widely accepted chemotherapeutic agent. However, one of the disadvantages of 5-FU is its fast metabolism, which requires frequent administration to maintain the desired serum concentration level, so the preparation of suitable sustained-release vehicles can effectively overcome these limitations. [0003] There have been some researches on the drug carrier of 5-FU at home and abroad. For example, the prior art discloses that 5-FU is slowly added to a chitosan solution, cross-linked into spheres by addin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/02A61K31/513A61P35/00
CPCA61K9/1652A61K9/1611A61K31/513A61P35/00Y02A50/30
Inventor 胡盛杨喆房佳慧李翔冯驸谭志伟田大听
Owner HUBEI UNIV FOR NATITIES
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