A kind of composite drug-carrying gel and preparation method thereof

A gel and drug-carrying technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of drug molecule activity loss, obvious burst release effect, etc., to slow down the burst Release phenomenon, improve mechanical properties, improve the effect of water dispersion performance

Active Publication Date: 2022-07-19
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the object of the present invention is a composite drug-loaded gel and its preparation method to solve the problem that the existing drug-loaded gel has obvious burst release effect and easily leads to the loss of activity of drug molecules

Method used

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preparation example Construction

[0026] The embodiment of the present invention provides a preparation method of a composite drug-loaded gel, comprising the following steps:

[0027] S1, adding pyrrole and dopamine hydrochloride into water and mixing evenly, then adding ammonium persulfate, stirring and reacting, and centrifuging and washing to obtain a polypyrrole-polydopamine nanocomposite;

[0028] S2, placing the nanocomposite material in a 1 mol / L hydrochloric acid solution containing drug molecules and a graphene oxide aqueous solution in turn, and centrifugally adsorbing to obtain a graphene oxide-polypyrrole-polydopamine nanocomposite drug-loading material;

[0029] S3. After mixing the nano-composite drug-carrying material with the water-soluble polymer solution, adding a calcium chloride solution, stirring and then standing, the composite drug-carrying gel is obtained.

[0030] Specifically, in step S1, the mass ratio of pyrrole, dopamine hydrochloride and ammonium persulfate is 1:(1-2):(1-3), the t...

Embodiment 1

[0043] The present embodiment provides a preparation method of a composite drug-loaded gel, which specifically includes the following steps:

[0044] 1) Add 1 mmol of pyrrole and 2 mmol of dopamine hydrochloride into 30 mL of water with pH=8 and mix well, add 3 g of ammonium persulfate to it, stir and react at 4°C for 24 h, and then centrifuge and wash to obtain polypyrrole-polydopamine nanocomposite. Material;

[0045] 2) 1 mg of polypyrrole-polydopamine nanocomposite was placed in 1 mol / L dilute hydrochloric acid and graphene oxide aqueous solution containing doxorubicin hydrochloride successively for 24 hours, and centrifugal adsorption was performed to obtain graphene oxide-polypyrrole-polydopamine nanocomposites. The composite drug-carrying material, the concentration of doxorubicin hydrochloride is 4mg / mL, the volume of dilute hydrochloric acid is 1mL, the concentration of graphene oxide is 1mg / mL, and the volume of graphene oxide solution is 2mL;

[0046] 3) After mixi...

Embodiment 2

[0049] The present embodiment provides a preparation method of composite drug-loaded gel, and the difference from embodiment 1 is:

[0050] In step 1), add 1 mmol of pyrrole and 2 mmol of dopamine hydrochloride into 30 mL of water with pH=9 and mix well;

[0051] In step 2), 2 mg of polypyrrole-polydopamine nanocomposite was placed in 1 mol / L dilute hydrochloric acid and graphene oxide aqueous solution containing methotrexate for 36 h, and centrifugal adsorption was performed to obtain graphene oxide-polypyrrole-polydopamine. Nanocomposite drug-loading material, the concentration of methotrexate is 0.5mg / mL, the volume of dilute hydrochloric acid is 2mL, the concentration of graphene oxide is 2mg / mL, and the volume of graphene oxide solution is 1mL;

[0052] In step 3), after mixing 2 mg of graphene oxide-polypyrrole-polydopamine nanocomposite drug-carrying material with sodium alginate aqueous solution, calcium chloride solution is added, and after stirring, let stand for 36h...

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Abstract

The invention provides a composite drug-carrying gel and a preparation method thereof. The preparation method includes the following steps: S1. Add pyrrole and dopamine hydrochloride into water and mix evenly, then add ammonium persulfate, stir and react, and centrifuge and wash to obtain polypyrrole -Polydopamine nanocomposite material; S2, placing the nanocomposite material in a 1mol / L hydrochloric acid solution containing drug molecules and a graphene oxide aqueous solution in turn, and centrifugal adsorption to obtain graphene oxide-polypyrrole-polydopamine nanocomposite drug-loading material; S3. After mixing the nano-composite drug-carrying material with the water-soluble polymer solution, adding calcium chloride solution, stirring, and letting it stand, the composite drug-carrying gel is obtained. The composite drug-carrying material provided by the invention is compounded with a water-soluble polymer, which can promote the formation of the composite drug-carrying gel, slow down the sudden release phenomenon at the initial stage of drug release, and at the same time, the composite drug-carrying gel has multiple stimuli responsiveness.

Description

technical field [0001] The invention relates to the technical field of functional polymer composite materials, in particular to a composite drug-carrying gel and a preparation method thereof. Background technique [0002] Gel is a material with a three-dimensional network structure, which is ubiquitous in people's production and life, especially in the fields of bioengineering and medicine, which has a wide range of research and applications. This material is usually a three-dimensional polymer network formed by polymer chains, which can absorb and retain a large amount of water or biological fluids, while being insoluble in water due to physicochemical cross-linking. Hydrogel materials formed by hydrophilic polymers exhibit thermodynamic compatibility with water, that is, they can swell in aqueous media, and have been widely used in controlled drug release, sensors, tissue engineering and other fields. [0003] At present, most of the gel-loaded drugs are physically encaps...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/34A61K47/04A61K31/704A61K31/519A61K47/61
CPCA61K9/06A61K47/34A61K47/02A61K31/704A61K31/519A61K47/61
Inventor 杜寒威喻湘华李亮刘辉刘玉兰
Owner WUHAN INSTITUTE OF TECHNOLOGY
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