Colon-targeted sinomenine hydrochloride slow-release nanofiber membrane and preparation method and application thereof
A technology of sinomenine hydrochloride and nanofiber membrane, applied in nanotechnology, nanomedicine, nanotechnology and other directions, can solve the problems of reducing the sudden release of water-soluble drugs and side effects of the digestive tract, so as to reduce the sudden release phenomenon and maintain the efficacy of the drug , reducing the effect of irritation
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[0033] Example 1
[0034] A preparation method of colon-targeted sinomenine hydrochloride sustained-release nanofiber membrane, comprising:
[0035] (1) Weigh 2.2508g of polyacrylic acid resin Eudragit S100 with an analytical balance, add it to a mixed solution of 3.6430g N,N-dimethylacetamide and 9.110g absolute ethanol, heat and stir to obtain a shell layer spinning solution . Among them, the concentration of absolute ethanol is ≥99.7%, the concentration of N,N-dimethylacetamide is ≥99.5%, the heating temperature is 50°C, and the stirring time is 8h;
[0036] (2) Weigh 0.2503g of polyacrylic resin Eudragit RS100 and 0.3003g of sinomenine hydrochloride with an analytical balance, add them to a mixed solution of 1.2720g of chloroform and 3.1781g of absolute ethanol, and stir at room temperature to obtain a core layer spinning solution. Among them, the concentration of absolute ethanol is greater than or equal to 99.7%, and the concentration of chloroform is greater than or e...
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[0045] Example 2
[0046] A preparation method of colon-targeted sinomenine hydrochloride sustained-release nanofibrous membrane is basically the same as the method in Example 1, and the difference is:
[0047] In step (1), the amount of polyacrylic resin Eudragit S100 is 2.2501g; the solution is 6.3750g of N,N-dimethylacetamide mixed with 6.3750g of absolute ethanol. The rest of the steps are the same.
[0048] In step (3), in the electrospinning process, the voltage of the positive electrode is +17KV, and the ambient temperature is 26°C, and the drug-loading amount of the obtained drug-loaded nanofiber membrane is 20%-30%.
[0049] The in vitro release amount of the coaxial drug-loaded sustained-release nanofiber membrane in Example 2 was determined by the same method as in Example 1. The nanofiber membrane prepared in Example 2 of the present invention released only about 5% in two hours in a simulated stomach environment with pH 1.2, and only released about 4% in two hou...
Example Embodiment
[0050] Example 3
[0051] A preparation method of colon-targeted sinomenine hydrochloride sustained-release nanofibrous membrane is basically the same as the method in Example 1, and the difference is:
[0052] In step (1), the amount of polyacrylic resin Eudragit S100 is 2.2498g; the solution is 6.3750g of N,N-dimethylacetamide mixed with 6.3750g of absolute ethanol. The rest of the steps are the same.
[0053] In step (2), weigh 0.2503g of polyacrylic acid resin Eudragit RS100 and 0.3003g of sinomenine hydrochloride; add them to a mixed solution of 1.0556g of chloroform and 3.6944g of absolute ethanol, and stir at room temperature to obtain a core layer spinning solution . Among them, the concentration of absolute ethanol is greater than or equal to 99.7%, and the concentration of chloroform is greater than or equal to 99.0%; the stirring time is 4h;
[0054] In step (3), in the electrospinning process, the voltage of the positive electrode is +17KV, and the ambient tempe...
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