Colon-targeted sinomenine hydrochloride slow-release nanofiber membrane and preparation method and application thereof
A technology of sinomenine hydrochloride and nanofiber membrane, applied in nanotechnology, nanomedicine, nanotechnology and other directions, can solve the problems of reducing the sudden release of water-soluble drugs and side effects of the digestive tract, so as to reduce the sudden release phenomenon and maintain the efficacy of the drug , reducing the effect of irritation
Inactive Publication Date: 2020-04-17
GUANGXI UNIV FOR NATITIES
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The invention discloses a colon-targeted sinomenine hydrochloride slow-release nanofiber membrane and a preparation method and application thereof. The nanofiber membrane comprises a shell layer and acore layer coated in the shell layer, wherein the shell layer comprises the following components: Eudragit S100 or Eudragit RS100; the core layer comprises the following components: any one or more than two of Eudragit S100, Eudragit RS100, polycaprolactone and polyvinylpyrrolidone, and sinomenine hydrochloride. The drug loading capacity of sinomenine hydrochloride in the nanofiber membrane is 10%-30%. According to the sinomenine hydrochloride slow-release nanofiber membrane with the shell-core structure, slow release and targeting of the drug are realized and the membrane has good biocompatibility.
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Sinomenine hydrochlorideDrug loading dose +10
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Property | Measurement | Unit |
The inside diameter of | 0.25 | mm |
The inside diameter of | 0.85 | mm |
tensile | MPa | |
Particle size | Pa | |
strength | 10 |
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