Hydrophobic medical thermoplastic polyurethane alloy

A thermoplastic polyurethane, hydrophobic technology, used in catheters and other directions, can solve problems such as limited sources, and achieve the effects of large supply, high hardness, and softening tissue irritation.

Active Publication Date: 2015-06-24
WEIHAI JIERUI MEDICAL PRODUCTS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the two polyurethane raw materials used to prepare the polyurethane blend need to be specially synthesized and the sources are limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Component A medical grade hydrophobic thermoplastic polyurethane Tecoflex EG-72D and component B medical grade hydrophobic thermoplastic polyurethane Tecoflex EG-85A were weighed in a weight ratio of 90 / 10. Tecoflex EG-72D is produced by Lubrizol, with a Shore hardness of 67D. Tecoflex EG-85A is produced by Lubrizol, with a Shore hardness of 77A. The two were mixed in a high-speed mixer for 5 minutes, and then transferred to a hopper type dehumidification drier at 80° C. for 4-6 hours to obtain a dry mixture. Add the dry compound into the twin-screw extruder for melt mixing. The screw diameter of the extruder is 36mm, the aspect ratio is 28 / 1, and the temperature from the feed port to the die of the extruder is set at 140- 180 ° C, the die temperature is 180 ° C, the blend is extruded through the die, cooled, and pelletized to obtain a polyurethane alloy. The test shows that the flexural modulus (GB / T9341-2000) of the alloy is 670MPa at 23°C, and after 24 h...

Embodiment 2

[0016] Example 2: Component A medical grade hydrophobic thermoplastic polyurethane Elastollan 1174D and component B medical grade hydrophobic thermoplastic polyurethane Elastollan 1185A were weighed in a weight ratio of 55 / 45. Elastollan 1174D is produced by BASF, with a Shore hardness of 73D. Elastollan 1185A is produced by BASF, with a Shore hardness of 85A. The two were mixed in a high-speed mixer for 5 minutes, and then transferred to a hopper type dehumidification drier at 110° C. for 3-5 hours to obtain a dry mixture. Add the dry compound into the twin-screw extruder for melt mixing. The screw diameter of the extruder is 36mm, the aspect ratio is 28 / 1, and the temperature from the feed port to the die of the extruder is set at 190- 215 ° C, the die temperature is 215 ° C, the blend is extruded through the die, cooled, and pelletized to obtain a polyurethane alloy. The test shows that the flexural modulus (GB / T9341-2000) of the alloy is 564MPa at 23°C, and after 24 hour...

Embodiment 3

[0017] Example 3: Component A medical grade hydrophobic thermoplastic polyurethane Pellethane 2363-75D and component B medical grade hydrophobic thermoplastic polyurethane Pellethane 2363-80A were weighed in a weight ratio of 70 / 30. Pellethane 2363-75D is produced by Lubrizol, with a Shore hardness of 76D. Pellethane 2363-80A is produced by Lubrizol, with a Shore hardness of 81A. The two are mixed in a high-speed mixer for 5 minutes, and then transferred to a hopper-type dehumidification dryer at 110° C. for 3-5 hours to obtain a dry mixture. Add the dry compound into the twin-screw extruder for melt mixing. The screw diameter of the extruder is 36mm, the aspect ratio is 28 / 1, and the temperature from the feed port to the die of the extruder is set at 190- 215 ° C, the die temperature is 215 ° C, the blend is extruded through the die, cooled, and pelletized to obtain a polyurethane alloy. The test shows that the flexural modulus (GB / T9341-2000) of the alloy is 726MPa at 23°C...

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Abstract

The invention discloses a hydrophobic medical thermoplastic polyurethane alloy which comprises acomponent A and a component B, wherein the component A is commercial medical level hydrophobic thermoplastic polyurethane with shore hardness of 65 to 78 D, which takes 55% to 90% of the alloy total weight; the component B is commercial medical level hydrophobic thermoplastic polyurethane with shore hardness of 75 to 95 D, which takes 10% to 45% of the alloy total weight. The characteristic of hardness of the component A can be maintained when the medical thermoplastic polyurethane alloy is stored in indoor temperature dry environment, after entering into the human body, the medical thermoplastic polyurethane alloy can absorb moisture which takes 1.0% to 5.0% of the medical thermoplastic polyurethane alloy weight and can be softened; compared with the storage, the modulus is declined by more than 70%. The raw material of the hydrophobic medical thermoplastic polyurethane alloy is wide, the preparation is simple, the hardness is high in indoor temperature environment, and the stimulating degree to organization can be reduced, and the hydrophobic medical thermoplastic polyurethane alloy can resist bending and is favor of involving in human body, can be softened in the human body obviously and is suitable for preparing medical interventional catheter.

Description

technical field [0001] The invention belongs to the technical field of modification of medical thermoplastic polyurethane, and specifically relates to a hydrophobic medical thermoplastic polyurethane alloy which has high hardness when stored in a dry environment at room temperature and can be greatly softened after entering a human body. Background technique [0002] The field of medical interventional catheters has been used for decades. During the intervention process, the catheter generally needs a steel needle that is good for piercing the skin to enter the human body or blood vessels smoothly. Nevertheless, it is still required that the materials used to manufacture catheters, especially small-sized catheters, have relatively high hardness, so as to ensure that the catheter does not retract and improve the success rate of one-time intervention. At the same time, it is also required that the catheter has sufficient flexibility after entering the human body, so as to red...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L75/04A61L29/06
Inventor 杨华伟殷敬华张德海石强尹立刚张晓伟黄尉
Owner WEIHAI JIERUI MEDICAL PRODUCTS CO LTD
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