Colon-targeted gel microsphere with controllable core-shell ratio, and preparation and application of colon-targeted gel microsphere

Abstract

The invention provides a colon-targeted gel microsphere with a controllable core-shell ratio, and preparation and application of the colon-targeted gel microsphere. The gel microsphere comprises a core layer, an inner shell layer and an outer shell layer from inside to outside in sequence, wherein the core layer comprises cereal prolamin and an active matter; the inner shell layer comprises gel polysaccharide; the outer shell layer comprises chitosan, a cross-linking agent and a suspending aid. The inner shell layer and the core layer form core-shell structure fog drops through a coaxial electrostatic spraying technology, in an outer shell layer solution, the inner shell layer gel polysaccharide of the core-shell structure fog drops is cross-linked with the cross-linking agent and is subjected to electrostatic layer-by-layer adsorption with chitosan, and therefore, the colon-targeted gel microsphere is prepared. The particle size of the gel microsphere is 100-600 [mu] m, the core-shell ratio is 0.5-0.9, the encapsulation efficiency of a water-soluble active matter is as high as 60%, the encapsulation efficiency of an alcohol-soluble active matter is as high as 90%, the release amounts in a stomach simulation liquid and a small intestine simulation liquid within 1 h and 3 h can be as low as 10% and 25%, and the gel microsphere can be efficiently delivered and targeted to the colon.

Description

technical field [0001] The invention belongs to the technical field of colon delivery system preparation. More specifically, it relates to a colon-targeting gel microsphere with a controllable core-shell ratio and its preparation and application. Background technique [0002] Colon diseases are divided into inflammatory colon diseases, ischemic colon diseases, neoplastic colon diseases, etc., and the current treatment methods for colon-related diseases are limited, mainly including oral administration and rectal administration. Discomfort and the range of administration is limited, the drug cannot reach the upper part of the colon, and has little effect on the inflammation that occurs in the cecum and upper colon. For oral administration, in order to make the drug reach the colon and release it smoothly, and improve the efficiency of action, the colon-targeted delivery of drug materials is a current research hotspot. [0003] As a type of colon-targeted delivery material, ...

AI Technical Summary

Problems solved by technology

Patent CN106702597A discloses a core-shell structure nanofiber membrane and its preparation method and application. The nanofiber membrane prepared by coaxial electrospinning has a single-layer core-shell structure and the core-shell ratio is uncontrollable. The wall material used Although it is a polysaccharide material, a variety of polymers are added to promote film formation, and multi-step preparation is required, the operation is cumbersome, and the fibrous membrane structure limits its application in oral delivery systems

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