Antibacterial wound dressing and preparation method thereof

A wound dressing and composite antibacterial technology, which is applied in medical science, textiles, papermaking, bandages, etc., can solve the problems of unclear chronic toxic reactions, achieve the effects of preventing wound fluid infection, good water resistance, and promoting wound healing

Inactive Publication Date: 2014-12-10
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] At present, in the research on antibacterial dressings loaded with antibacterial agents, most of them are based on the research and application of silver-loaded antibacterial dressings, and there are few reports on drugs loaded with organic antibacterial agents. However, the biological negative effects of nano-silver on the human body, especially The chronic toxicity of long-term frequent use or large-scale use is not very clear

Method used

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  • Antibacterial wound dressing and preparation method thereof
  • Antibacterial wound dressing and preparation method thereof
  • Antibacterial wound dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] Such as figure 1 Shown is a schematic structural view of the antibacterial composite wound dressing of the present invention. The antibacterial composite wound dressing includes chitosan-based drug-loaded composite antibacterial microfiber membrane 1, alginic acid Calcium fiber non-woven fabric 2 and supporting protective layer 3. The supporting protective layer 3 is polyacrylate pressure-sensitive adhesive.

[0038] The concrete steps of the preparation method of described antibacterial composite wound dressing are:

[0039] Add antimicrobial drug ciprofloxacin hydrochloride powder in the acetic acid aqueous solution that mass fraction is 90%, make it fully dissolve with magnetic stirrer stirring, take chitosan and polyoxyethylene powder and join in the above-mentioned solution, stir to obtain uniform, Stable spinning solution, the concentration of polyethylene oxide in the spinning solution is 0.5wt%, the weight ratio of chitosan and polyethylene oxide is 90:10, and...

Embodiment 2

[0043] Such as figure 1 Shown is a schematic structural view of the antibacterial composite wound dressing of the present invention. The antibacterial composite wound dressing includes chitosan-based drug-loaded composite antibacterial microfiber membrane 1, alginic acid Calcium fiber non-woven fabric 2 and supporting protective layer 3. The supporting protection layer 3 is provided with polyacrylate pressure-sensitive adhesive.

[0044] The concrete steps of the preparation method of described antibacterial composite wound dressing are:

[0045] Add antimicrobial drug ciprofloxacin hydrochloride powder in the acetic acid aqueous solution that mass fraction is 90%, make it fully dissolve with magnetic stirrer stirring, take chitosan and polyoxyethylene powder and join in the above-mentioned solution, stir to obtain uniform, Stable spinning solution, the concentration of polyethylene oxide in the spinning solution is 0.5wt%, the weight ratio of chitosan and polyethylene oxide...

Embodiment 3

[0049] Such as figure 1 Shown is a schematic structural view of the antibacterial composite wound dressing of the present invention. The antibacterial composite wound dressing includes chitosan-based drug-loaded composite antibacterial microfiber membrane 1, alginic acid Calcium fiber non-woven fabric 2 and supporting protective layer 3. The supporting protective layer 3 is a polyethylene film with biological glue.

[0050] The concrete steps of the preparation method of described antibacterial composite wound dressing are:

[0051] Add antibacterial drug powder moxifloxacin hydrochloride to 90% acetic acid aqueous solution by mass fraction, stir it with a magnetic stirrer to fully dissolve it, weigh chitosan and polyethylene oxide powder and add it to the above solution, and stir to obtain a uniform, stable spinning solution, the concentration of polyoxyethylene in the spinning solution is 0.5wt%, the weight ratio of chitosan and polyoxyethylene is 90:10, and the weight rat...

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Abstract

The invention provides an antibacterial wound dressing and a preparation method thereof. The antibacterial compound type wound dressing is characterized by comprising a chitosan-based medicine carrying compound antibacterial ultrafine fibrous membrane, a calcium alginate fiber non-woven fabric and a supporting protective layer which are sequentially arranged from top to bottom. The medicine carrying ultrafine fibrous membrane obtained by adopting an electrostatic spinning method has the advantages that the surface area of a medicament can be effectively increased, medicines can be slowly and sustainably released by virtue of high porosity and uniform pore diameter of ultrafine fibers, so that the medicines can be fully absorbed by a human body, medication is not need to be carried out frequently, the effect of the medicines can be maintained, and toxic and side effects of the medicines are reduced.

Description

technical field [0001] The invention belongs to the technical field of preparation of composite antibacterial wound dressings, and in particular relates to a novel medical dressing with antibacterial, hemostatic and healing functions and a preparation method thereof. Background technique [0002] At present, traditional dressings are mainly used for nursing care of skin injuries caused by trauma, scalds, burns, bedsores, diabetic ulcers, varicose ulcers, and surgical incisions. However, there are defects such as no antibacterial properties, poor air permeability, and easy adhesion, which can easily lead to repeated damage and damage to the skin, slow down the healing speed, and cause adverse consequences such as secondary bacterial infections. Among them, bacterial infection is one of the main factors affecting wound healing. Wound exudate contains a large number of inflammatory factors, proteases and free radicals, which will affect the speed of wound healing. The developm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/42D04H1/728
Inventor 高晶程凤王璐万倩
Owner DONGHUA UNIV
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