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Chitosan collagen and calcium alginate compounded spongy biological dressing and its preparation process

A biological dressing and composite sponge technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of time-consuming, high power consumption, and constraints on the industrialization of collagen sponge dressings, and achieve smooth surface, uniform mesh, and in vitro degradation rate moderate effect

Inactive Publication Date: 2002-11-20
JIANGXI RUIJI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process requires secondary freeze-drying, which consumes a lot of power and is time-consuming, thus becoming a bottleneck restricting the industrialization of collagen sponge dressings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh chitosan 8kg and calcium alginate 1.5kg, dissolve in 0.05M acetic acid to 2% (W / V), stir the solution at room temperature for 1 hour, then incubate overnight at room temperature and remove in a dust-free atmosphere. The bubbles remaining in the solution were slowly added to the homogeneous solution of type I collagen (0.5kg). Add 0.25% glutaraldehyde cross-linking agent 0.8kg to the above mixed solution, put it in the refrigerator at 4°C for 4 hours, add buffer solution to adjust the pH value of the solution to 5-7, add emulsifier 0.02kg monostearic fatty acid glyceride and stir well, use colloid The mill grinds the solution into a homogeneous liquid. Install the template in a -30°C refrigerator and pre-freeze for 4 hours. Quickly transfer the pre-frozen collagen template to a freeze dryer and vacuum freeze-dry for 12-24 hours. After the sample temperature rises to room temperature, gradually heat it to 105°C and keep the temperature for 4 hours. Sponge dressing,...

Embodiment 2

[0018] Weigh 40kg of chitosan and 2kg of calcium alginate, dissolve in 0.05M acetic acid to 2% (W / V), stir the solution at room temperature for 1 hour, then incubate overnight at room temperature to remove the solution in a dust-free atmosphere Slowly add the remaining air bubbles in the homogeneous solution of bovine tendon collagen 8kg. Dissolve 0.15kg of chondroitin sulfate in 0.05M acetic acid, add dropwise to the above mixed solution and keep stirring, then add 0.1kg of calcium chloride cross-linking agent, put it in the refrigerator at 4°C for 4 hours, add buffer to adjust the pH value of the solution to 5-7, Add 0.01 kg of emulsifier polyglycerol fatty acid ester and stir evenly, and use a colloid mill to grind the solution into a uniform liquid. Install the template in a -30°C refrigerator and pre-freeze for 4 hours. Quickly transfer the pre-frozen collagen template to a freeze dryer and vacuum freeze-dry for 12-24 hours. After the sample temperature rises to room temp...

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PUM

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Abstract

The composite spongy biological dressing contains chitosan, collagen and calcium alginate with weigh tmixing ratio o f 0.5-8:0.5-8:0.1-8. Its preparation method includes the following steps: selecting chitosan and collagen type I, adding calcium alginate, compounding and cross-linking, using buffer solution to make neutralization, emulsifying, prefreezing and one-step freeze-drying so as to obtain the invented dressing with good biological compatibility and strong adhesion property. Said invented dressing possesses active function of promoting wound healing and hemostatic action, can be combined with anti-bacterial medicine to obtain gene engineeirng dressing for curing wound surface infection, also can be combined with active growth factor or active cell to form gene engineering dressingfor curing intractable ulcer and burn wound surface.

Description

technical field [0001] The invention relates to a medical device dressing, in particular to a biodegradable spongy dressing. Background technique [0002] Wound repair is one of the most important and fundamental issues facing surgery and the medical profession as a whole. Experts predict that the number of traumatized people will double in the 21st century. The demand for wound dressings will also face a new climax that continues to rise. The traditional dressing (gauze) only plays the role of simply covering the wound. With the rapid development of modern medicine, especially molecular biology, the concept of modern dressing has undergone fundamental changes, that is, the dressing should not only cover the wound, but also have Promote the function of tissue repair, provide a growth environment for new tissue, accelerate wound healing, reduce scars, and prevent bacterial contamination; and use its biodegradability to reduce the number of dressing changes. [0003] An ide...

Claims

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Application Information

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IPC IPC(8): A61L15/12A61L15/22A61L15/28
Inventor 苗九昌傅筱冲张莉莉饶国厚
Owner JIANGXI RUIJI BIOTECH CO LTD
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