Preparation method of porous dressing of silk fibroin-calcium alginate biological wound

Abstract

The invention relates to a preparation method of porous dressing of a silk fibroin-calcium alginate biological wound in the technical field of skin care products and medical apparatuses and instruments. The preparation method specifically comprises the steps: dissolving fibrous silk fibroin formed after a silkworm cocoon is degummed, filtering, dialyzing and concentrating so as to obtain silk fibroin water solutions with different weight concentrations; mixing deionized water and calcium alginate with a defined amount of silk fibroin solution, placing the obtained gelatinous solution in an environment with a normal temperature to obtain a gel film, freezing and drying the gel film to obtain the porous dressing of the fibroin-calcium alginate biological wound. The excellent biocompatibility is realized; the deionized water and the calcium alginate in the raw materials are both natural active materials, are used commonly used for the health-care food industry without stimulation on the skin, and are good in hygroscopicity and water-absorbing quality; the silk fibroin and the calcium alginate both have the high water holding rate property, thereby being relatively good in affinity property on the skin.

Description

technical field [0001] The invention relates to the technical field of skin care products and medical devices, in particular to a preparation method of silk fibroin-calcium alginate biological wound dressing. Background technique [0002] The skin is the largest organ of the human body and the first physical barrier between the human body and the external environment. It plays an important role in preventing the invasion of harmful substances from the outside, excreting and preventing water evaporation, regulating body temperature, and keeping the body in a stable internal environment. The use of different wound dressings can effectively promote the repair of damaged skin and accelerate wound healing. Due to the poor hydrophilic performance of traditional wound dressings, the wound dressings are hard and brittle, and often cause secondary physical damage to the injured skin, and bacteria can enter the edge of the dressing to grow; secondly, the traditional wound dressing has...

AI Technical Summary

Problems solved by technology

Due to the poor hydrophilic performance of traditional wound dressings, the wound dressings are hard and brittle, and often cause secondary physical damage to the injured skin, and bacteria can enter the edge of the dressing to grow; secondly, the traditional wound dressing has a large microstructure pore size, The porosity is low, the air permeability of the skin is not good, the slow-release effect of the drug is not good, and the effect of promoting skin healing is not very good