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Antigen peptide chain group for treating tumor as well as application thereof to medicines

An antigen peptide and drug technology, applied in the field of malignant tumor bioimmune drugs, can solve problems such as hearing loss, side effects, blurred vision, etc., and achieve the effect of small incidence of side effects, killing tumor cells, and obvious changes.

Inactive Publication Date: 2018-09-04
天津亨佳生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many methods of biological immunotherapy for tumors, including common CIK cell immunotherapy, DC drug therapy, etc., but the therapeutic effect is not significant, and the survival rate of patients has not been significantly improved
In addition, immune cells stimulated by non-mutated tumor highly expressed proteins have been studied for anti-tumor immune responses, but due to their non-specific expression, there are side effects, including blurred vision, hearing loss, rash, etc.

Method used

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  • Antigen peptide chain group for treating tumor as well as application thereof to medicines
  • Antigen peptide chain group for treating tumor as well as application thereof to medicines
  • Antigen peptide chain group for treating tumor as well as application thereof to medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]Patient A, female, 63 years old. Lung adenocarcinoma, lung metastasis, clinical stage IV, progressed after 4 times of NP chemotherapy, KRAS molecular targeted drug resistance. A lung lesion biopsy was taken, and after whole exome sequencing and HLA typing chip detection, the patient carried the KRAS p.G12C mutation, and the HLA typing was HLA-A: A*2103A*3501; HLA-B: B*3117B *3101; HLA-C: C*0301C*0612; HLA-DQB1: DQB1*0218DQB1*1111; HLA-DRB1: DRB1*0101DRB1*0101.

[0036] Use the specific tumor antigen peptide chain combination therapy of the present invention once a week for a total of 6 weeks. Detect the secretion of specific CD8+Tetramer+T cells by spot detection before and after the injection of antigen peptide chain group (hereinafter referred to as "medication"), and observe the changes in tumor size 6 weeks before and after the administration by imaging. The results are as follows: figure 1 with figure 2 shown. The specific peptide chain selection is as follows:...

Embodiment 2

[0041] Patient B, female, 60 years old, lung adenocarcinoma, no indication for surgery, received intravenous chemotherapy with gemcitabine + cisplatin for 6 weeks, and was resistant to oral gefitinib. After whole exome sequencing and HLA typing chip detection, the patient carried the KRAS p.G12C mutation, and the HLA typing was HLA-A: A*0202A*6201; HLA-B: B*0201B*3201; HLA-C: C*0302C*0201; HLA-DQB1: DQB1*0202DQB1*0230; HLA-DRB1: DRB1*0214DRB1*1221.

[0042] Combination therapy was performed with the antigen peptide chain group for treating tumors of the present invention once a week for a total of 12 weeks. The specifically selected peptide chain is as follows: SEQ ID No:2.

[0043] The changes in the size of lung tumors before and after treatment are as follows: image 3 shown by image 3 It can be seen that before drug treatment, the size of the left lung tumor was 4cm×5cm ( image 3 -A); 11 weeks after drug treatment, the left lung tumor basically disappeared ( image ...

Embodiment 3-93

[0045] Example 3-93 Cancer patients of different types and degrees were taken. After whole exome sequencing and HLA typing chip detection, the patients were all patients with KRAS p.G12C mutation, and different combinations of antigen peptide chain groups were used respectively. The treatment was performed once a week for 12 weeks. The results of HLA*A3101-HVKITDFGR Tetramer staining in Example 3-93 and the changes in the size of lung tumors before and after treatment are similar to those in Example 1-2, and will not be repeated here due to space limitations. The above results can all show that the antigen peptide chain group of the present invention can induce dendritic cells that produce tumors, and dendritic cells as antigen-presenting cells can present antigen information to T cells, interact with T cells, and cause T cells to produce tumors. It specifically kills tumor cells, plays a role in killing tumor cells, and the effect is obvious.

[0046] During the treatment of...

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Abstract

The invention discloses an antigen peptide chain group applied to tumor individualized biological immunotherapy as well as the application thereof to medicines. The antigen peptide chain group for treating tumor comprises at least one of SEQ ID No:1-93 or combination of at least two amino acid sequences. The antigen peptide chain group can induce dendritic cells capable of generating tumor, so thedendritic cells serving as antigen-presenting cells can present antigen information to T cells and interact with the T cells, the T cells generate specific tumor killing cells, and the effect of killing the tumor cells is achieved.

Description

technical field [0001] The invention belongs to the technical field of malignant tumor bioimmune drugs, and in particular relates to an antigen peptide chain group for individualized biological immunotherapy of tumors and its application in medicine. Background technique [0002] At present, the global incidence of malignant tumors is increasing, the mortality rate is high, and the prognosis is poor. The National Cancer Prevention and Research Office of the National Cancer Center released the largest comprehensive analysis of cancer survival data in China in the International Journal of Cancer. The data shows that the 5-year survival rate of cancer in China is 30.9%, which is far lower than that of developed countries; at the same time, the survival rate of rural patients is only half of urban patients. In developed countries, prostate cancer and breast cancer account for the majority. In China, cancers such as lung cancer, gastric cancer, and liver cancer are more common, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K7/08A61K39/00A61P35/00
CPCC07K7/06A61K39/0011A61P35/00C07K7/08
Inventor 刘玉强霍冲
Owner 天津亨佳生物科技发展有限公司
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