94 results about "Biological immunity" patented technology

The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.

The invention provides an up-converting phosphor (UCP) bio-detector and a method for detecting sampling test strips. The UCP bio-detector consists of an optical system, a photo-detector, a control system, a driving module, a stepping motor and a scanning platform for placing the test strips, wherein, the control system comprises a micro-processor, a photo-detector interface, a signal acquisition circuit, a driving module interface, an LCD (liquid crystal display) module, a matrix keyboard, an RFID (radio frequency identification) module, a D / A (digital to analog) converter, a memorizer, an SD (secure digital) memory card and a micro-printer; and each test strip consists of test paper mounted inside the casing of the test strip and an RFID card, the test paper comprises a sample pad, a detection band and a quality control band, and the RFID card contains the information including test paper ID, substances to be detected, decision values, a parameter A and a parameter B. The control system of the invention has the advantages of simple design and convenient debugging, and the biological immunological detection can be carried out rapidly and accurately.

The invention relates to a dipterex bionic enzyme linked immunosorbent detection method. The bionic enzyme linked immunosorbent detection method with high sensitivity on the dipterex is established by using a dipterex molecular imprinting polymer film as an artificial antibody instead of a biological antibody and by utilizing an enzyme linked immunosorbent assay principle. The lowest detection limit of the method is 7 ugL<-1> and is far less than the highest residue limit value; and the analysis time is greatly shortened (by 1.0 hour compared with the traditional biological immune analysis time), so the method is applicable to rapid detection of the dipterex. A bionic antibody prepared by the method can be reused for more than 50 times, so cost is greatly reduced; and the method is simplein pretreatment, high in sensitivity, simple in test operation and applicable to rapid detection of the dipterex in various kinds of food.

The invention belongs to the technical field of immunobiology and particularly relates to application for a patent of a PRV (pesudorabies virus) gB monoclonal antibody and application thereof. The antibody is obtained by screening PRV variant strains HeNZK-2014 and PRV gB proteins with hybridoma cells. The hybridoma cells capable of stably secreting the PRV gB protein monoclonal antibody is obtained through screening, so that the gB protein monoclonal antibody with high potency is obtained, a finished kit is prepared from the antibody, and a matched one-step competitive ELISA detection method is established. Through a series of verification for specificity, sensitivity and repeatability, the result indicates that according to the PRV gB antibody provided in the application and the established one-step competitive ELISA detection method, a comparatively accurate and comparatively stable detection result is achieved, the result can be better used for detection and evaluation of the PRV gB antibody, and the foundation is laid for preventing and controlling a PRV.

The invention discloses a group of proteins with allergen activity from metupcllu ensis, a preparation technology thereof and application thereof in medicine, and belongs to the field of natural bioactive substances and preparation technologies and medical applications thereof. The invention provides a group of proteins with allergen activity in a tissue of the metupcllu ensis, and molecular weights of the proteins are 21.6KDa, 36KDa, 46.2KDa, 60KDa, 64.8KDa, 68KDa, 78KDa and 88.5KDa, respectively. The operation according to the invention can obtain main allergen protein compositions of the metupcllu ensis which have high-purity and maintain good immunobiologic activity. The main allergen protein compositions of the metupcllu ensis produced by the invention can be used to prepare diagnostic reagents and desensitizing preparations for clinical shrimp-induced anaphylaxis and prepare reagents used to detect shrimp food allergen.

The invention discloses a preparation method of a biological immunosensor which has an electrochemiluminescence and photoelectrochemistry dual signal developed strategy and is constructed on the basis of a functional nano material.The prepared immunosensor is easy to operate, convenient to carry, rapid in detection, low in cost and capable of being used for rapid and sensitive detection on parathion-methyl in the fields of daily production and life and the like.

The invention discloses a preparation method of a biological immunity sensor which is based on functional nano-material construction and has dual signal development strategies of electrogenerated chemiluminescence and photoelectrochemistry, and the prepared sensor is easy to operate, convenient to carry, fast in detection, low in cost and capable of being used for fast and sensitive detection of estradiol in the fields of routine production and life and the like.

The invention relates to an oestrone derivative for detecting oestrone content in a biological sample and a preparation method of the oestrone derivative. The structural formula of the oestrone derivative is shown as a formula (I). Oestrone immunogens with high immunogenicity and corresponding antibodies are prepared in succession by using the oestrone derivative. The oestrone immunogen is high inspecificity and high in immunogenicity, and the anti-oestrone specific antibody is high in specificity and high in titer, is capable of well recognizing and binding oestrone, and does not have any cross reaction with common 92 chaff interferents. The invention further discloses an oestrone enzyme-labeled conjugate, and an oestrone homogeneous enzyme immunoassay detection reagent is prepared by utilizing the anti-oestrone specific antibody and the oestrone enzyme-labeled conjugate. The reagent is capable of conveniently, rapidly, and accurately measuring the oestrone content in the biologicalsample, multiple samples are determined on a full-automatic biochemical analyzer, high throughput and rapid determination of the oestrone is realized, the accuracy is high, the specificity is high, and the accuracy and detection efficiency are greatly improved compared with the previous detection.

For the first time individual (free from impurities of penta- and hexa-acetylated derivatives) di-, tri- and tetra-acetylated S-LPS of endotoxic bacteria and combinations thereof were obtained and their immunobiological, physical-chemical and chemical-pharmaceutical properties were studied.For the first time the principal possibility of their clinical application was directly demonstrated as vaccines and pharmaceutical compositions containing the modified S-LPS individual as monocomponent or combinations thereof as two and three component active substance, respectively.The modified S-LPS and combinations thereof have high safety profile and provide low pyrogenicity and high immunogenicity. Developed on their basis vaccines and pharmaceutical compositions demonstrate anti-shock activity, high efficiency and specificity, broad-spectrum action and also good chemical-pharmaceutical parameters.

The invention belongs to the field of immunobiology and relates to immunogenic polypeptide of 71-type VP1 antigen of enterovirus, a preparation method and application thereof, and particularly relatesto the immunogenic polypeptide of the 71-type VP1 antigen of the enterovirus. The immunogenic polypeptide has an amino acid sequence shown as any sequence of SEQ ID NO.1-SEQ ID NO.5 in a sequence table, or an amino acid sequence formed by substituting, deleting or adding one or more amino acids for the sequence and with equal functions. The invention also relates to the preparation method of theimmunogenic polypeptide and the application to preparation of a diagnostic reagent for EV71 viruses. The immunogenic polypeptide has good antigenicity and immunogenicity and provides research basis for early development of the diagnostic reagent and vaccine research and development of EV71.

The invention discloses a preparation method of a bioimmune sensor with dual signal development strategies of electrochemiluminescence and photoelectrochemistry constructed on the basis of functional nanomaterials. The prepared sensor is simple to operate, easy to carry, fast to detect, and low in cost, and can be used in Rapid and sensitive detection of ethinyl estradiol in daily production, life and other fields.