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Pharmaceutical composition for preventing or treating sexual dysfunction and application of pharmaceutical composition

A technology for erectile dysfunction and composition, applied in the field of medicine, can solve the problems such as treatment and/or prevention of sexual dysfunction that are not disclosed with alprostadil and ginkgolide

Inactive Publication Date: 2020-01-17
CHENGDU BAIYU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] After searching, the prior art does not disclose a pharmaceutical composition using these two types of compounds of prostadil and ginkgolide as active ingredients for the treatment and / or prevention of sexual dysfunction

Method used

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  • Pharmaceutical composition for preventing or treating sexual dysfunction and application of pharmaceutical composition
  • Pharmaceutical composition for preventing or treating sexual dysfunction and application of pharmaceutical composition
  • Pharmaceutical composition for preventing or treating sexual dysfunction and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0129] Embodiment 1 ginkgolide alprostadil injection

[0130] Alprostadil 0.25 mg, ginkgolide 100 g, supplemented with conventional pharmaceutical excipients for injections, prepared by conventional preparation methods for injections.

Embodiment 2

[0131] Embodiment 2 ginkgolide alprostadil injection

[0132] Alprostadil 10 mg, ginkgolide 50 g, supplemented with conventional pharmaceutical excipients for injections, prepared by conventional preparation methods for injections.

Embodiment 3

[0133] Embodiment 3 ginkgolide alprostadil injection

[0134] Alprostadil 80 mg, ginkgolide 10 g, supplemented with conventional pharmaceutical excipients for injections, prepared by conventional preparation methods for injections.

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Abstract

The invention discloses a pharmaceutical composition containing ginkgo terpene lactones and alprostadil and application of the pharmaceutical composition in preparation of a pharmaceutical compositionfor preventing or treating sexual dysfunction, and belongs to the medical field. Specifically, the weight ratio of the ginkgo terpene lactones to the alprostadil in the disclosed pharmaceutical composition is (1.1*10<5>-1*10<2>):1. The ginkgo terpene lactones and the alprostadil have a synergistic effect after being combined for use, can effectively prevent and / or treat sexual dysfunction, can beused for treating male erectile dysfunction, and particularly have good treatment effects on vascular, senile and neurogenic erectile dysfunction. The disclosed pharmaceutical composition has high efficacy, takes effect quickly, acts for a long term and can improve sexual intercourse intensions of patients, and meanwhile, the occurrence rate of side effects of the medicine is reduced, and the possibility of developing multiple preparation forms is increased.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition containing ginkgolide and alprostadil, and its use in preparing a pharmaceutical composition for preventing and / or treating sexual dysfunction. Background technique [0002] Erectile dysfunction (erectile dysfunction, ED) is a male sexual dysfunction, refers to the persistent inability of the penis to achieve and (or) maintain a sufficient erection for satisfactory sexual life (coitus). ED is a common and frequently-occurring disease in andrology. According to statistics, 52% of men aged 40 to 70 have different degrees of ED. According to the statistics of WHO, the global ED patients have reached 150 million people, and the global incidence rate is 4% (Duan Xueguang. An overview of tadalafil treatment of ED. "Chinese Journal of Andrology". 2013-19(4): 380-383 ). The occurrence of ED not only affects the quality of life of patients, but also brin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/365A61K31/5575A61P15/10A61P15/00
CPCA61K31/365A61K31/5575A61P15/00A61P15/10A61K2300/00
Inventor 鄢云彪李慧琴刘科金振东
Owner CHENGDU BAIYU PHARMA CO LTD
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