The invention provides eye drops for epidemic keratoconjunctivitis. The eye drops are prepared from radix saposhnikoviae, senecio scandens, mint, centipeda minima, concha haliotidis, crocus sativus, white mulberry root-bark, borneol, semen cuscutae, ash bark, herba ecliptae, liriope spicata, honeysuckle, buddleja officinalis, plantain herbs, schizonepeta, glossy privet fruit, coptis chinensis, flatstem milkvetch seeds, Chinese yam, polygonum aviculare, prunella vulgaris, paper mulberry fruit, feather cockscomb seeds, raspberries, pipewort, common bluebeard herbs and sticktight. The eye drops have few side effects and are stable in treatment effect, reliable, high in safety and high in clinical application value.