The invention provides a rat
periodontitis model and a construction method and application thereof, on the basis of ligating a
tooth neck of a first
molar of an SD (
Sprague Dawley) rat by a traditional silk thread, light-cured composite resin is bonded in the
occlusion direction of the silk thread to manufacture an appearance high point, the silk thread is fixed, a tartar is simulated, and an
occlusion high point is formed; meanwhile, the
gingival sulcus of the first
molar of the upper jaw is cooperatively inoculated with human
periodontitis pathogenic bacteria, the implementation method is simple, the
repeatability is good, the stability is high, the silk thread loosening rate is reduced to 3.13% when modeling is carried out for 28 days, the loosening rate is greatly reduced compared with 34.38% of a traditional silk thread
ligation model, subsequent experiment steps are simplified, lasting
gingivitis cell infiltration is caused, and the method is suitable for popularization and application. The number of inflammatory cells is 63.27 + / -7.07% when modeling is carried out for 28 days, experimental
periodontitis models of different degrees can be constructed within 2-4 weeks, compared with a traditional model, forming is faster, the model is closer to periodontitis clinical characteristics, and a model basis is provided for researching intervention strategies of different stages.