Epristeride sustained-release pellets and preparation method thereof
A technology of Aprelate and sustained-release pellets, which is applied in the field of Aprelate sustained-release pellets and its preparation, which can solve the problems of packaging, transportation, and storage inconvenience, low drug release stability, and large gastrointestinal irritation and other issues, to achieve the effect of improving bioavailability, small individual differences, and easy absorption
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[0027] Example 1
[0028] A sustained-release pellet of Aplite, comprising a coating layer and a drug-containing pellet; it is characterized in that: the coating layer is wrapped on the outer side of the drug-containing pellet; the coating layer comprises: 35-175mg Ute Qi NE30D, 5-53 mg of talc; the drug-containing pellets include: 5 mg of Epilite, 80 mg of blank core, 195-250 mg of filler, 10-50 mg of lubricant, and 5-25 mg of binder.
[0029] The coating layer also includes a trace amount of one or two of sodium lauryl sulfate and polyethylene glycol.
[0030] The preferred weight ratio in the coating layer is: 132mg Eudragit NE30D, 7mg talc.
[0031] The preferred weight ratio in the drug-containing pellets is: 5 mg of Eplite, 80 mg of blank pill core, 235 mg of filler, 20 mg of lubricant, and 10 mg of binder.
[0032] The filler is microcrystalline cellulose, the lubricant is talc, and the binder is hypromellose.
Example Embodiment
[0033] Example 2
[0034] Its production method includes the following steps:
[0035] Step 1: Material preparation: According to the above-mentioned mass ratio, use a pulverizer to pulverize the Eplite, and pass it through a 100-mesh sieve;
[0036] Step 2: Mixing: Weigh Epilite and Microcrystalline Cellulose according to the above-mentioned mass ratio, put them into a three-dimensional mixer and mix for 30 minutes to make medicine subdivisions, and take them out for use;
[0037] Step 3: preparation of adhesive: weigh an appropriate amount of hypromellose according to the above-mentioned mass ratio, add an appropriate amount of hot water to prepare an adhesive with a concentration of 2%, for use;
[0038] Step 4: Pill making: put the medicine into the feeding tank of the centrifugal pill making machine, put the adhesive into the liquid supply tank, put the blank pill core in the pot, turn on the machine, adjust the parameters, and start spraying. When the pill ...
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