Finely prepared controlled release preparation for coronary disease and its preparation process

A technology for controlled release preparation and coronary heart, which is applied in the field of refined coronary controlled release preparation and its preparation technology, can solve the problems of large dosage of refined coronary heart tablet and backward technological conditions, and achieves improvement of curative effect, reduction of taking times, and carrying handy effect

Inactive Publication Date: 2011-11-16
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The refined Guanxin Tablets recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China has a large dosage, 6 to 8 tablets at a time, 3 times a day, the technological conditions are backward, and there is no quantitative detection index

Method used

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  • Finely prepared controlled release preparation for coronary disease and its preparation process
  • Finely prepared controlled release preparation for coronary disease and its preparation process
  • Finely prepared controlled release preparation for coronary disease and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Extract and separate the various medicinal materials in the refined Guanxin formula, for example: extract the effective fraction group mainly composed of Danshensu by water extraction and alcohol precipitation method and / or other methods; use water extraction and alcohol precipitation method and / or different concentrations of ethanol (including After extracting with water), use macroporous resin separation method and / or other methods to extract the effective fraction group mainly based on paeoniflorin; use water extraction and alcohol precipitation method and / or different concentrations of ethanol (including water) to extract and use macroporous resin separation method and / or other methods to extract the effective part group mainly based on ferulic acid; after extraction with water extraction and alcohol precipitation method and / or different concentrations of ethanol (including water), use macroporous resin separation method and / or other methods to extract safflower Yell...

Embodiment 2

[0052] Each medicinal material in the refined Guanxin prescription extracts and separates with reference to embodiment 1, adopts the tablet (also can be capsule) that the known method of pharmaceutical industry is made to contain following component by weight percentage:

[0053] Tablet Prescription:

[0054] Salvia Extract 23.0%

[0055] Paeoniae Rubra Extract 5.4%

[0056]Chuanxiong Extract 1.2%

[0057] Safflower Extract 11.5%

[0058] Aroma essential oil-β-cyclodextrin inclusion complex 7.9%

[0059] Bergamot Extract 0.7%

[0060] Hypromellose K4M 8.9%

[0061] Sodium chloride 10.0%

[0062] Lactose 10.0

[0063] Polyoxyethylene (PEO) 20.4%

[0064] Magnesium Stearate 1.0%

[0065] Proper amount of ethanol solution

[0066] Coating Solution Prescription:

[0067] Acetate 75%

[0068] PEG-4000 25%

[0069] Using film coating technology, the refined coronary heart is made into a double-layer osmotic pump controlled release tablet, and the drug-containing layer i...

Embodiment 3

[0071] The refined Guanxin osmotic pump tablet prepared in Example 1 and the refined Guanxin ordinary tablet of the same dose were used to conduct pharmacokinetic studies in vivo with Beagle dogs. The relative bioavailability of paeoniflorin was 98.7%, and the blood drug concentration curve in the body was shown in attached figure 2 .

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Abstract

Disclosed is a finely prepared controlled release preparation for coronary disease and its preparation process, which is prepared from red sage root, radix paeoniae rubrathe, Ligusticum wallichii, safflower and dalbergia wood and / or extract 10-80%, adjuvant 20-70% for controlled release action, and balancing medicinal auxiliary materials. The film material employs cellulose acetate and / or ethyl cellulose, the auxiliary materials include polyoxyethylenes and / or methyl hydroxypropylcellulose.

Description

technical field [0001] The present invention relates to a controlled-release preparation containing medicinal materials and / or extracts such as Danshen, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Safflower and Dalbergia basilica. Specifically, it is a refined controlled-release preparation for coronary heart disease and its preparation process, which is used for treating cardiovascular disease. Coronary heart disease due to blood stasis, angina pectoris. technical background [0002] Traditional Chinese medicine has a long history, and there are a large number of compound prescriptions with definite curative effects. However, at present, most of the drug dosage forms are still in common preparations, and there are very few controlled-release traditional Chinese medicine preparations with high efficiency, long-acting and small doses. With the development of excipients, the application of technology and the advanced preparation technology of traditional Chinese medicine, it has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22
Inventor 潘卫三杨星钢李伟彭博
Owner SHENYANG PHARMA UNIVERSITY
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