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Red yeast rice and glossy ganoderma composition and its preparation method and application

A technology of Monascus ganoderma and its composition, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve problems such as skin health damage, cancer damage, and reduced eye function, so as to improve sleep, reduce the incidence of toxic and side effects, and improve effect of effect

Pending Publication Date: 2021-09-03
杭州雪域生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. Sleep disorders will cause certain damage to our skin health
[0008] 5. The decrease of immunity is also one of the harms caused by sleep disorders, and the decrease of immunity will make our body unable to effectively resist the invasion of some germs, thus promoting the occurrence of various diseases
[0009] 6. Sleep disorders may also cause us to be attacked by malignant tumor diseases such as cancer
[0013] 2. Reduce eye function
[0015] 3. Affect the blood supply to the brain
[0020] Long-term hyperlipidemia may accelerate atherosclerosis of arteries, which is not good for arterial health

Method used

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  • Red yeast rice and glossy ganoderma composition and its preparation method and application
  • Red yeast rice and glossy ganoderma composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The fruiting body of Ganoderma lucidum is extracted by ultrasonic microwave enzymatic hydrolysis synergistic method. The technological conditions are: 1 kg of decoction pieces of fruiting body of Ganoderma lucidum, adding water to a liquid-to-material ratio of 10:1, pH value 6, adding 20 U of cellulase per gram of medicinal material, and enzymatic hydrolysis temperature of 48 ℃, enzymatic hydrolysis time 50 minutes, 95 ℃ to inactivate enzyme for 5 minutes, temperature dropped to 80 ℃, placed in ultrasonic-microwave synergistic extraction apparatus for extraction, microwave power set at 280W, extraction time 30 minutes, proper vacuum concentration and freeze-drying to obtain 131g ganoderma lucidum extract thing. The content of polysaccharides, triterpenes and sterols (calculated as oleanolic acid) in the Ganoderma lucidum extract was measured to be 11.7% and 10.9%, respectively.

Embodiment 2

[0055] The fruiting body of Ganoderma lucidum is extracted by ultrasonic microwave enzymatic hydrolysis synergistic method. The technological conditions are: 1 kg of decoction pieces of fruiting body of Ganoderma lucidum, adding water to a liquid-solid ratio of 15:1, pH value of 5, adding 100 U of cellulase per gram of medicinal material, and enzymatic hydrolysis temperature of 38 ℃, enzymatic hydrolysis time 60min, 85℃ to inactivate the enzyme for 15min, the temperature dropped to 72℃, placed in an ultrasonic-microwave synergistic extractor for extraction, the microwave power was set at 320W, the extraction time was 20min, properly concentrated and freeze-dried in a vacuum to obtain 162g of Ganoderma lucidum extract thing. The content of polysaccharides, triterpenes and sterols (calculated as oleanolic acid) in the Ganoderma lucidum extract was measured to be 17.1% and 6.7%, respectively.

Embodiment 3

[0057] The fruiting bodies of Ganoderma lucidum are extracted by ultrasonic microwave enzymatic hydrolysis synergistic method. The technological conditions are: 1 kg of decoction pieces of Ganoderma lucidum fruiting bodies, adding water to a liquid-to-material ratio of 12:1, pH value 5.5, adding 60 U of cellulase per gram of medicinal materials, and enzymatic hydrolysis temperature of 43 ℃, enzymatic hydrolysis time 55 minutes, 90 ℃ to inactivate the enzyme for 10 minutes, the temperature dropped to 76 ℃, placed in an ultrasonic-microwave synergistic extraction apparatus for extraction, the microwave power was set at 300W, the extraction time was 25 minutes, properly concentrated and freeze-dried in a vacuum to obtain 152g of Ganoderma lucidum extract thing. The content of polysaccharides, triterpenes and sterols (calculated as oleanolic acid) in the Ganoderma lucidum extract was measured to be 16.6% and 9.2%, respectively.

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Abstract

The present invention discloses a composition of red yeast rice and ganoderma and an application thereof. The composition is prepared by adding a proper amount of water to red yeast rice and ganoderma extract, uniformly mixing the water and the red yeast rice and the ganoderma extract and then freeze-drying the mixture. The composition of red yeast rice and ganoderma can be used for preparing medicines for treating and / or preventing hyperlipemia and / or improving sleep. The dosage forms comprise tablets, capsules, injections or oral liquid, and the composition of red yeast rice and ganoderma obtains obvious synergistic interaction.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine and health food, in particular to a combination of red yeast rice and ganoderma lucidum and applications thereof. Background technique [0002] Sleep disorder is a disease with a relatively high incidence rate. Long-term sleep disorder will seriously affect our mental state, resulting in a great drop in our work efficiency and learning efficiency, and a decrease in memory. Therefore, we must deeply understand the importance of sleep. The serious harm of sleep disorders, once you find that you have sleep disorders, you must seek the help of a professional doctor as soon as possible, and scientifically treat sleep disorders in a timely manner. [0003] Long-term sleep disturbance can produce the following harms: [0004] 1. Obesity is one of the hazards caused by sleep disorders. Relevant studies have shown that lack of sleep can lead to a decrease in the level of fat-reduci...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/062A61K36/074A61K31/366A61K31/22A61P3/06A61P25/20A61P3/10
CPCA61K36/899A61K36/062A61K36/074A61K31/366A61K31/22A61P3/06A61P25/20A61P3/10A61K2236/19A61K2300/00
Inventor 徐深录金李洁李肖娟李其
Owner 杭州雪域生物技术有限公司
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