Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof

A technique for slow-release preparations of coronary heart, which is applied in the field of refined coronary heart sustained-release preparations and its preparation, and can solve the problems of large dosage of refined coronary heart tablets and backward process conditions, etc.

Inactive Publication Date: 2006-02-22
SHENYANG PHARMA UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The refined Guanxin Tablets recorded in the 2005 edition of the Pharmacopoeia of the People's Republic of China has a large dosage, 6 to 8 tablets at a time, 3 times a day, the technological conditions are backward, and there is no quantitative detection index

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof
  • Finely prepared sustained-releasing formulation for coronary disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Extract and separate the various medicinal materials in the refined Guanxin formula, for example: extract the effective fraction group mainly composed of Danshensu by water extraction and alcohol precipitation method and / or other methods; use water extraction and alcohol precipitation method and / or 50%-98% After extraction with concentrated ethanol (including water), use macroporous resin separation method and / or other methods to extract the active fraction group mainly based on paeoniflorin; Porous resin separation method and / or other methods to extract the effective fraction group mainly composed of ferulic acid; after extraction with water extraction and alcohol precipitation method and / or different concentrations of ethanol (including water), use macroporous resin separation method and / or other methods Extract the active part group mainly composed of safflower yellow pigment; extract the volatile oil of balsamic balm by steam distillation and / or other methods, and in...

Embodiment 2

[0040] Each medicinal material in the refined Guanxin formula is extracted and separated with reference to Example 1, and the tablet of Example 2 made by a method known in the pharmaceutical industry contains the following ingredients by weight percentage:

[0041] Salvia Extract 23.0%

[0042] Paeoniae Rubra Extract 5.4%

[0043] Chuanxiong Extract 1.2%

[0044] Safflower Extract 11.5%

[0045] Aroma essential oil-β-cyclodextrin inclusion complex 7.9%

[0046] Bergamot Extract 0.7%

[0047] Carbopol 32.9%

[0048] Lactose 16.4%

[0049] Magnesium Stearate 1.0%

[0050] 60% ethanol solution appropriate amount

Embodiment 3

[0052] Each medicinal material in the refined Guanxin formula is extracted and separated with reference to Example 1, and the present Example 3 tablet made by a method known in the pharmaceutical industry contains the following ingredients by weight percentage:

[0053] Salvia Extract 27.5%

[0054] Radix Paeoniae Alba Extract 6.5%

[0055] Chuanxiong Extract 1.5%

[0056] Safflower Extract 13.8%

[0057] Aroma essential oil-β-cyclodextrin inclusion complex 9.5%

[0058] Bergamot Extract 0.8%

[0059] Sodium Alginate 35.5%

[0060] Calcium Alginate 3.9%

[0061] Magnesium Stearate 1.0%

[0062] 75% ethanol solution appropriate amount

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to finely prepared sustained-releasing formulation for coronary disease and preparation process, whose constituents (percentage by weight) are, root of red rooted saliva, radix paeoniae rubrathe, Ligusticum wallichii, safflower herbs and / or extract 10-80%, adjuvant for slow release action 20-90%, and balancing medicinal auxiliary materials.

Description

Technical field: [0001] The present invention relates to a sustained-release preparation containing medicinal materials and / or extracts such as Salvia miltiorrhiza, Radix Paeoniae Rubra, Chuanxiong, safflower, and Dalbergia basilica. Specifically, it is a refined coronary heart sustained-release preparation and its preparation method, which is used for treating cardiovascular disease. Coronary heart disease due to blood stasis, angina pectoris. technical background: [0002] Traditional Chinese medicine has a long history, and there are a large number of compound prescriptions with definite curative effects. However, at present, most of the drug dosage forms are still in common preparations, and there are very few sustained-release traditional Chinese medicine preparations with high efficiency, long-acting effect and small dosage. With the development of excipients, the application of technology and the advanced preparation technology of traditional Chinese medicine, it has ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/22A61P9/10
Inventor 潘卫三杨星钢彭博张志宏
Owner SHENYANG PHARMA UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap