Compound amino acid preparation for hemodialysis and hemodialysis preparation containing same

Abstract

The invention relates to a compound amino acid preparation for hemodialysis and a hemodialysis preparation containing the same. The invention provides a preparation for modulating disorder of plasma aminogram of hemodialysis patients by using a plurality of essential amino acids and semi-essential amino acids, specifically relates to a solid powder form or liquid bicarbonate hemodialysis preparation used for treating nephrosis and containing compound amino acids, and especially to a hemodialysis preparation containing L-leucine, L-isoleucine, L-valine, L-threonine, L-phenylalanine, L-methionine, L-tryptophan, L-lysine, L-histidine, L-arginine and a pH conditioning agent (e.g., acetic acid, citric acid, malic acid, lactic acid and hydrochloric acid) and a preparation method thereof. The hemodialysis preparation further contains sodium chloride, potassium chloride, calcium chloride, magnesium chloride and sodium bicarbonate, and can also include glucose. Compared to conventional bicarbonate hemodialysis preparations, the preparation provided in the invention has the advantages of partly modulating disorder of plasma aminogram of hemodialysis patients and reducing side effects in hemodialysis treatment.

Description

Technical field

[0001] The invention relates to a compound amino acid for hemodialysis, in particular to a hemodialysis preparation for kidney patients using various amino acids as nutritional supplements in hemodialysis treatment and a preparation method thereof. Background technique

[0002] As we all know, the impairment of renal function will increase the chance of malnutrition in patients with kidney disease. Many experiments have proved that in acute renal failure and chronic renal failure, protein and amino acid metabolism is abnormal, which is manifested by abnormal plasma amino acid levels and intracellular amino acid levels. The reasons are related to many factors: 1. Loss of appetite, vomiting, diarrhea, long-term low-protein diet, so that essential amino acids are reduced. 2. The kidney's ability to excrete non-essential amino acids decreases, resulting in an increase in non-essential amino acids. 3. Patients with renal failure and hemodialysis often have VitB 6 The ...

Examples

Embodiment 1

[0018] Take the following various amino acid raw materials according to the following weight parts: L-leucine 12.9g, L-isoleucine 9.3g, L-lysine 10g, L-methionine 14.14g, L-phenylalanine 16.15g , L-valine 9.3g, L-threonine 5.8g, L-tryptophan 3.8g, L-histidine 6.4g, L-arginine 11.6g, sieved and mixed uniformly, packaged in a container in.

example 2

[0020] Take the following various amino acid raw materials according to the following weight parts respectively; L-leucine 12.9g, L-isoleucine 9.3g, L-lysine 10g, L-methionine 14.1g, L-phenylalanine 16.1g , L-valine 9.6g, L-threonine 5.8g, L-tryptophan 3.8g, L-histidine 6.4g, L-arginine 11.6g, dissolved in purified water, adjusted with a pH regulator The pH is close to neutral. After sterilization and filtration, the concentrated liquid is filled into a container, filled with nitrogen and sealed.

example 3

[0022] Take the following various amino acid raw materials according to the following weight parts: L-leucine 14.6g, L-isoleucine 10.6g, L-lysine 11.3g, L-methionine 16g, L-phenylalanine 18.2g, L-valine 10.9g / , L-threonine 6.6g, L-tryptophan 4.3g, and L-histidine 7.3g were sieved and mixed uniformly and packaged in a container.

Technical field

[0001] The invention relates to a compound amino acid for hemodialysis, in particular to a hemodialysis preparation for kidney patients using various amino acids as nutritional supplements in hemodialysis treatment and a preparation method thereof. Background technique

[0002] As we all know, the impairment of renal function will increase the chance of malnutrition in patients with kidney disease. Many experiments have proved that in acute renal failure and chronic renal failure, protein and amino acid metabolism is abnormal, which is manifested by abnormal plasma amino acid levels and intracellular amino acid levels. The reasons are related to many factors: 1. Loss of appetite, vomiting, diarrhea, long-term low-protein diet, so that essential amino acids are reduced. 2. The kidney's ability to excrete non-essential amino acids decreases, resulting in an increase in non-essential amino acids. 3. Patients with renal failure and hemodialysis often have VitB 6 The ...

Examples

Embodiment 1

[0018] Take the following various amino acid raw materials according to the following weight parts: L-leucine 12.9g, L-isoleucine 9.3g, L-lysine 10g, L-methionine 14.14g, L-phenylalanine 16.15g , L-valine 9.3g, L-threonine 5.8g, L-tryptophan 3.8g, L-histidine 6.4g, L-arginine 11.6g, sieved and mixed uniformly, packaged in a container in.

example 2

[0020] Take the following various amino acid raw materials according to the following weight parts respectively; L-leucine 12.9g, L-isoleucine 9.3g, L-lysine 10g, L-methionine 14.1g, L-phenylalanine 16.1g , L-valine 9.6g, L-threonine 5.8g, L-tryptophan 3.8g, L-histidine 6.4g, L-arginine 11.6g, dissolved in purified water, adjusted with a pH regulator The pH is close to neutral. After sterilization and filtration, the concentrated liquid is filled into a container, filled with nitrogen and sealed.

example 3

[0022] Take the following various amino acid raw materials according to the following weight parts: L-leucine 14.6g, L-isoleucine 10.6g, L-lysine 11.3g, L-methionine 16g, L-phenylalanine 18.2g, L-valine 10.9g / , L-threonine 6.6g, L-tryptophan 4.3g, and L-histidine 7.3g were sieved and mixed uniformly and packaged in a container.