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Antigen peptide chain group for treating tumors and application thereof in medicines

An antigen peptide and drug technology, applied in the field of malignant tumor bioimmune drugs, can solve the problems of difficult side reactions and non-specificity

Inactive Publication Date: 2018-05-18
天津亨佳生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, DCs induced by tumor-associated high-expression proteins are not strictly specific, and tissue cells other than tumors also express the same protein, so its side effects are a problem

Method used

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  • Antigen peptide chain group for treating tumors and application thereof in medicines
  • Antigen peptide chain group for treating tumors and application thereof in medicines
  • Antigen peptide chain group for treating tumors and application thereof in medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Patient A, female, 47 years old. Lung squamous cell carcinoma, liver metastases, clinical stage IV, lung tumor treated with iodine 125 seed implantation once, progressed after 3 times of gemcitabine single-drug chemotherapy, progressed after chemoembolization for liver metastases, EGFR molecular targeted drug resistance . Multiple lung metastases, liver metastases, pleural metastases, bone metastases, abdominal lymph node metastases. A lung lesion biopsy was taken, and after whole exome sequencing and HLA typing chip detection, the patient carried EGFR p.T790M, and the HLA typing was HLA-A: A*0216A*3002; HLA-B: B*1502B* 5801; HLA-C: C*0303C*1203; HLA-DQB1: DQB1*0401DQB1*0602; HLA-DRB1: DRB1*1101DRB1*1501.

[0063] Use the specific tumor antigen peptide chain combination therapy of the present invention once a week for a total of 6 weeks. Detect the secretion of specific CD8+Tetramer+T cells by spot detection before and after the injection of antigen peptide chain gro...

Embodiment 2

[0079]Patient B, male, 70 years old, right lung adenocarcinoma, multiple lymph node metastases, no indication for surgery, received pemetrexed + cisplatin intravenous chemotherapy for 6 weeks, progressed after 1 cycle of pemetrexed chemotherapy, and received iodine 125 seed implantation. Progression after entry. After whole exome sequencing and HLA typing chip detection, the results showed that the patient carried the EGFRp.T790M mutation, and the HLA typing was HLA-A: A*0202A*0212; HLA-B: B*0702B*0808; HLA-C : C*0401C*0701; HLA-DQB1: DQB1*030302DQB1*0601; HLA-DRB1: DRB1*0401DRB1*1002.

[0080] Combination therapy was performed with the antigen peptide chain group for treating tumors of the present invention once a week for a total of 12 weeks. The specific selected peptide chains are as follows:

[0081] a) MQLMPFGCLLDY

[0082] b) TSTVQLIMQLMP

[0083] c) GICLTSTVQLIM

[0084] d) TSTVQLIMQLM

[0085] e)QLIMQLMPFGC

[0086] f) VQLIMQLMPF

[0087] g) QLIMQLMPF

[0088...

Embodiment 3-50

[0093] In Example 3-50, cancer patients of different types and degrees were treated with combinations of different antigen peptide chain groups, once a week for a total of 12 weeks. The results of HLA*A3101-HVKITDFGR Tetramer staining in Example 3-50 and the changes in the size of lung tumors before and after treatment are similar to those in Example 1-2, and will not be repeated here due to space limitations. The above results can all show that the antigen peptide chain group of the present invention can induce dendritic cells that produce tumors, and dendritic cells as antigen-presenting cells can present antigen information to T cells, interact with T cells, and cause T cells to produce tumors. It specifically kills tumor cells, plays a role in killing tumor cells, and the effect is obvious.

[0094] During the treatment of Examples 1-50, ELISA was used to detect the specific IFN-γ secretion before the antigen peptide chain was used, 3 weeks, 7 weeks, and 11 weeks after the...

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Abstract

The invention discloses an antigen peptide chain group for individualized biological immunotherapy of tumors and application thereof in medicines. The antigen peptide chain group for treating tumors is prepared from combination of any one or at least two amino acid sequences in SEQ ID NO:1-27. The antigen peptide chain group disclosed by the invention can generate dendritic cells of tumors by induction, and then the dendritic cells serving as antigen-presenting cells can present antigen information to T cells so as to interact with the T cells to enable the T cells to generate specific killingtumor cells, thereby achieving the effect of killing tumor cells.

Description

technical field [0001] The invention belongs to the technical field of malignant tumor bioimmune drugs, and in particular relates to an antigen peptide chain group for individualized biological immunotherapy of tumors and its application in medicine. Background technique [0002] At present, the global incidence of malignant tumors is increasing, the mortality rate is high, and the prognosis is poor. The National Cancer Prevention and Research Office of the National Cancer Center released the largest comprehensive analysis of cancer survival data in China in the International Journal of Cancer. The data shows that the 5-year survival rate of cancer in China is 30.9%, which is far lower than that of developed countries; at the same time, the survival rate of rural patients is only half of urban patients. In developed countries, prostate cancer and breast cancer account for the majority. In China, cancers such as lung cancer, gastric cancer, and liver cancer are more common, ...

Claims

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Application Information

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IPC IPC(8): C07K7/06C07K7/08A61K38/08A61K38/10A61P35/00A61P35/02
CPCC07K7/06A61K38/00C07K7/08
Inventor 刘玉强霍冲
Owner 天津亨佳生物科技发展有限公司
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