Antigen peptide chain group for treating tumor and application thereof to medicine

A technology of antigenic peptides and drugs, applied in the field of malignant tumor bioimmune drugs, can solve problems such as hearing loss, side effects, blurred vision, etc., and achieve the effect of low incidence of side effects, killing tumor cells, and obvious changes

Inactive Publication Date: 2018-08-24
天津亨佳生物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many methods of biological immunotherapy for tumors, including common CIK cell immunotherapy, DC drug therapy, etc., but the therapeutic effect is not significant, and the survival rate of patients has not been significantly improved
In addition, immune cells stimulated by non-mutated tumor highly expressed proteins have been studied for anti-tumor immune responses, but due to their non-specific expression, there are side effects, including blurred vision, hearing loss, rash, etc.

Method used

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  • Antigen peptide chain group for treating tumor and application thereof to medicine
  • Antigen peptide chain group for treating tumor and application thereof to medicine
  • Antigen peptide chain group for treating tumor and application thereof to medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Patient A, female, 48 years old. Lung metastasis of breast cancer, bilateral cervical lymph node metastasis, clinical stage IV, progression after 4 cycles of vinorelbine single-agent chemotherapy, resistance to targeted drugs. Multiple small nodules in the lungs, repeated pleural effusions, and multiple drainages. A biopsy of the lung lesions was taken. After whole-exome sequencing and HLA typing chip detection, the patient carried an insertion mutation in exon 20 of HER2 (ERBB2) , HLA type is HLA-A: A*3303A*3201; HLA-B: B*3017B*3101; HLA-C: C*0324C*0612; HLA-DQB1: DQB1*0208DQB1*1121; HLA-DRB1: DRB1 *0202DRB1*0601.

[0027] Use the specific tumor antigen peptide chain SEQ ID No: 1 of the present invention for treatment once a week for a total of 12 weeks. Detect the secretion of specific CD8+Tetramer+T cells by spot detection before and after the injection of the antigen peptide chain group (hereinafter referred to as "medication"), and observe the changes in tumor si...

Embodiment 2

[0032] Patient B, female, 62 years old, with lung metastases after gastric cancer surgery, progressed after 6 weeks of chemotherapy with oxaliplatin + capecitabine regimen. After performing whole exome sequencing and HLA typing chip detection on lung metastases biopsy, the patient carried an insertion mutation in exon 20 of HER2 (ERBB2), and the HLA typing was HLA-A: A*0302A*6501; HLA-B: B*0301B*3201; HLA-C: C*0334C*0501; HLA-DQB1: DQB1*0302DQB1*0330; HLA-DRB1: DRB1*0313DRB1*1221.

[0033] Combination therapy with the antigenic peptide chain SEQ ID No: 2 for treating tumors of the present invention, once a week, for 12 weeks in total.

[0034] The changes in the size of right lung metastases before treatment are as follows: image 3 shown by image 3 It can be seen that before drug treatment, the size of right lung metastases was 4cm×3cm ( image 3 -A); 12 weeks after drug treatment, the right lung metastases basically disappeared ( image 3 -B), the tumor was significantl...

Embodiment 3-101

[0036] Example 3-101 Cancer patients of different types and degrees were taken. After whole-exome sequencing and HLA typing chip detection, the patients were all patients with HER2 (ERBB2) exon 20 insertion mutations, and different antigens were used respectively. The combination form of the peptide chain group was treated once a week for a total of 12 weeks. The HLA*A3101-HVKITDFGR Tetramer staining results of Example 3-101 and the changes in the size of lung tumors before and after treatment are similar to those of Example 1-2, and will not be repeated here due to space limitations. The above results can all show that the antigen peptide chain group of the present invention can induce dendritic cells that produce tumors, and dendritic cells as antigen-presenting cells can present antigen information to T cells, interact with T cells, and cause T cells to produce tumors. It specifically kills tumor cells, plays a role in killing tumor cells, and the effect is obvious.

[003...

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Abstract

The invention discloses an antigen peptide chain group for tumor individualized biological immunotherapy and application thereof to medicine. The antigen peptide chain group for treating tumor comprises any one of SEQ ID No: 1 to 101 or a combination of at least two amino acid sequences. The antigen peptide chain group provided by the invention can induce dendritic cells that produce tumor, so that the dendritic cells as antigen-presenting cells can present antigen information to T cells, thereby interacting with the T cells to enable the T cells to generate specificity to kill tumor cells, and realizing the effect of killing the tumor cells.

Description

technical field [0001] The invention belongs to the technical field of malignant tumor bioimmune drugs, and in particular relates to an antigen peptide chain group for individualized biological immunotherapy of tumors and its application in medicine. Background technique [0002] At present, the global incidence of malignant tumors is increasing, the mortality rate is high, and the prognosis is poor. The National Cancer Prevention and Research Office of the National Cancer Center released the largest comprehensive analysis of cancer survival data in China in the International Journal of Cancer. The data shows that the 5-year survival rate of cancer in China is 30.9%, which is far lower than that of developed countries; at the same time, the survival rate of rural patients is only half of urban patients. In developed countries, prostate cancer and breast cancer account for the majority. In China, cancers such as lung cancer, gastric cancer, and liver cancer are more common, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K7/08A61K39/00A61P35/00
CPCC07K7/06A61K39/0011A61P35/00C07K7/08
Inventor 刘玉强李晓丹
Owner 天津亨佳生物科技发展有限公司
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