52results about How to "Reduce bone loss" patented technology

The invention relates to methods identify or characterize compounds that can be used to treat specified clinical disorders such as hyperglycemia and type 2 diabetes. Compounds that can be used in these methods include 4α-fluoro-17α-ethynylandrost-5-ene-3β,7β,17β-triol, 4α-fluoro-17α-ethynylandrost-5-ene-3β,7α,17β-triol, 4α-fluoro-17α-ethynylandrost-5-ene-3α,7β,17β-triol and 4α-fluoro-17α-ethynylandrost-5-ene-3β,17β-triol-7-one.

The invention relates to methods identify or characterize compounds that can be used to treat specified clinical disorders such as hyperglycemia and type 2 diabetes. Compounds that can be used in these methods include 4α-fluoro-17α-ethynylandrost-5-ene-3β, 7β,17β-triol, 4α-fluoro-17α-ethynylandrost-5-ene-3β,7α,17β-triol, 4α-fluoro-17α-ethynylandrost-5-ene-3α,7β,17β-triol and 4α-fluoro-17α-ethynylandrost-5-ene-3β,17β-triol-7-one.

A femoral neck fixation prosthesis and method of using same which reduces bone loss and the avoids the other shortcomings of the prior art by allowing the fixation of a stable femoral head replacement while reducing the amount of the femur which must be reamed for the insertion of the prosthesis. The preferred embodiment provides that the femoral head is attached to a fixation prosthesis, which extends coaxially through the canal of the femoral neck, into the femur, and is then attached to the opposite lateral wall of the femur. In this manner, the prosthesis serves to imitate the original structure of the femoral neck. No other support members, either crosspins or arms extending into the length of the femur, are required.

A femoral neck fixation prosthesis and method of using same which reduces bone loss and the avoids the other shortcomings of the prior art by allowing the fixation of a stable femoral head replacement while reducing the amount of the femur which must be reamed for the insertion of the prosthesis. The preferred embodiment provides that the femoral head is attached to a fixation prosthesis, which extends coaxially through the canal of the femoral neck, into the femur, and is then attached to the opposite lateral wall of the femur. In this manner, the prosthesis serves to imitate the original structure of the femoral neck. No other support members, either crosspins or arms extending into the length of the femur, are required.

The invention relates to an automatic splitting machine for beef carcasses. The automatic splitting machine comprises a work box with a base, a splitting device mounted on the work box as well as an enclasping device and a lifting system which are mounted in the work box, wherein the work box comprises an enclasping chamber, a driving chamber and a transmission chamber; the transmission chamber is positioned at the top of the enclasping chamber and the driving chamber; a support frame provided with a guide rail is arranged at the outer side of the enclasping chamber; two arc-shaped positioning boards are arranged at the outer side of the support frame; and the support frame and the positioning boards are fixedly connected between the extending part of a top board of the work box and the extending part of a bottom board of the base. C-shaped enclasping arms of the automatic splitting machine can enclasp a beef carcass to enable the beef carcass to be jointed on the two arc-shaped positioning boards so as to enable the spine to be positioned in a gap between the two arc-shaped positioning boards, and a circular saw blade is driven by the lifting system to split the beef carcass from bottom to top along the guide rail, thereby ensuring the splitting accuracy, reducing the loss of bones and beef, improving the working efficiency of the splitting operation and ensuring the appearance effect of a split section.

The invention relates to the technical field of microorganisms, and discloses lactobacillus plantarum for preventing and / or treating periodontitis as well as a culture, preparation and application of the lactobacillus plantarum. The name of the lactobacillus plantarum is Lactobacillus plantarum CCFM1137, the lactobacillus plantarum is preserved in Guangdong Microbial Culture Collection Center on the 5th floor of the Building 59, No. 100 Courtyard, Xianlie Middle Road, Guangzhou on August 1, 2020, and the preservation number is GDMCC No: 61114. The lactobacillus plantarum can be used for inhibiting the formation of a mixed bacterium biological membrane of porphyromonas gingivalis, prevotella intermedia and fusobacterium nucleatum; the content of inflammatory factors in a periodontitis cell model can be reduced; the expression quantity of transmembrane transport protein in a periodontitis cell model can be increased; and the lactobacillus plantarumcan be used for preventing and / or treating oral diseases and inhibiting prevotella intermedia, porphyromonas gingivalis and / or fusobacterium nucleatum.

An implant for transplanting tooth bone in it has a bullet-like shape, cylindrical upper half, conic lower half, external spiral thread, coated nano-apatitie layer on its external surface, and axial stepped internal hole with internal spiral thread on the inner surface of small-diameter segment.

The invention discloses a bone connecting device for treating femoral intertrochanteric fracture. The bone connecting device for treating femoral intertrochanteric fracture comprises a bone connecting plate, a circular knife and fixing screws, wherein the bone connecting plate comprises a bone connecting plate upper portion, a bone connecting plate middle portion and a bone connecting plate lower portion which are sequentially connected to one another; the bone connecting plate upper portion is arc-shaped; the bone connecting plate middle portion is obliquely arranged at the lower end of the bone connecting plate upper portion; the outer side of the bone connecting plate middle portion and the outer side of the bone connecting plate lower portion are straight; the bone connecting plate middle portion is thicker than the bone connecting plate upper portion and the bone connecting plate lower portion; a sleeve is arranged on the bone connecting plate middle portion; threads are arranged at the front end of the circular knife; and the rear of the circular knife does not have threads. When the bone connecting device is used, the circular knife is obliquely placed in a femoral head via a femoral neck from a greater trochanter, the threads of the circular knife are fixed in the femoral head, and the rear of the circular knife is slidably connected with the femoral neck and the sleeve; and the bone connecting plate upper portion and the bone connecting plate lower portion are provided with locking screw holes which are locked with the fixing screws in a threaded manner. By the mode, a fracture portion can be compressed, and a fracture line is reduced; and angular stability is high, displacement fracture can be prevented, injury is reduced, and healing on femoral intertrochanteric fracture is facilitated.

The invention discloses application of probiotics or outer membrane vesicles thereof to preparing medicines for preventing and treating osteoporosis. The probiotics is an Akk bacterium. The probioticsor the outer membrane vesicles of the probiotics can be used for increasing the bone volume fractions of distal-end cancellous bones of femurs, increasing the numbers of bone trabeculas and loweringthe separation of the bone trabeculas. The probiotics or the outer membrane vesicles of the probiotics can be used for preparing the medicines, food or healthcare products for preventing and treatingpostmenopausal osteoporosis. The application has the advantage that novel, safe and effective biotherapy directions can be provided to treating the osteoporosis and particularly the postmenopausal osteoporosis by the application.

The invention relates to a thoracic vertebra pedicle screw path detector which is characterized by comprising a handle (1), and the front end of the handle is connected with an arc-shaped smooth proof stick (2). The thoracic vertebra pedicle screw path detector has the advantages that the structure is simple, using is convenient, the detector is used in internal fixation of a thoracic vertebra pedicle screw, operation efficiency can be obviously improved, operation difficulty and complications are reduced, and operation wounds of a patient are reduced.

The invention discloses an application of Longistyline A-2-carboxylic acid in osteoclast formation inhibiting and osteoporosis preventing medicines. The chemical structural formula of the LongistylineA-2-carboxylic acid is shown in the description. The invention also provides an application of the Longistyline A-2-carboxylic acid in medicines for inhibiting the osteoclast marker gene expression in the osteoclast formation process, an application of the Longistyline A-2-carboxylic acid in medicines for inhibiting the RANKL-induced NF-kappa and NFAT pathway activity through inhibiting the expression level of proteins in the upstream and downstream pathways in the osteoclast differentiation process, and an application of the Longistyline A-2-carboxylic acid in medicines for inhibiting RANKL-induced reactive oxygen species (ROS) and important calcium ion oscillation reactions in the osteoclast differentiation process. RANKL-induced osteoclast formation and the functions of osteoclast areinhibited to reduce the bone loss in OVX mice; and the Longistyline A-2-carboxylic acid can improve the bone mineral density of OP patients, which proves that the Longistyline A-2-carboxylic acid canbe a potential choice for treating osteoporosis and other osteolytic diseases.

The invention relates to an internal fixation device for a fractured cancellous bone. The device specifically includes two parts including a screw nail body and a nail tail structure. The nail body isof a spiral spring-like structure with a sharp front portion, and the cross section of the screw nail body is circular. The screw pitch of the screw nail body and the cross section of the snail bodycan be appropriately changed according to materials and mechanical properties; the nail tail of the screw nail body is a hollow outer hexagonal nail tail, and the screw nail body rotates naturally tobe fused with the nail tail naturally. A hollow part of the nail tail is threaded and used for mounting a hexagonal screw-in wrench matched with the hollow part. The hexagonal screw-in wrench is hollow and is internally provided with a bolt which is in threaded match with the hollow part of the nail tail, and the bolt is also hollow and used for containing a navigation Kirschner wire. The hexagonal screw-in wrench is matched with the hexagonal nail tail. If the nail tail is U-shaped, when the nail body is screwed into a spine vertebral body, a round rod matched with the nail body can be placedfor fixation of the anterior spine.

Enantomerically purified phenothiazines are provided as active ingredients of medicaments to limit activity of bone resorbing cells so as to reduce bone loss. Novel phenothiazine derivatives are provided. A method of synthesizing enantiomerically pure phenothiazine derivatives is provided that avoids post-synthetic enantiomeric resolution.

The invention relates to traditional Chinese medicine composition for treating rheumatoid arthritis and bone destruction and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 10-20 parts of Japan sabia, 15-30 parts of malaytea scurfpea fruits, 15-30 parts of fortune's drynaria rhizomes, 9-15 parts of Chinese angelica and 15-20 parts of epimedium herbs. The traditional Chinese medicine composition has a remarkable inhibition function on toe swelling of a rheumatoid arthritis animal model, can remarkably reduce loss of bone mass around an inflammable joint of the rheumatoid arthritis animal model, improves the bone biomechanical parameter and inhibits bone destruction caused by rheumatoid arthritis; the traditional Chinese medicine composition has the advantages that a few raw materials are required, preparation is convenient, the cost is low, and no toxic and side effects are caused.

The invention discloses a medicinal composition for treating osteoporosis and a preparation method thereof, relating to the field of traditional Chinese medicine. The medicinal composition for treating osteoporosis consists of the following Chinese medicinal raw materials: pseudo-ginseng root, dragon's blood, safflower, frankincense, rhubarb, Chinese angelica, szechuan lovage rhizome, myrrh, prepared rehmannia root, red paeony root, white paeony root, fortune's drynaria rhizome, himalayan teasel root, slenderstyle acanthopanax bark, borax and natural copper. The medicinal composition is prepared by organically blending a plurality of medicaments, has the effect of treating both principal and secondary aspects of a disease, and has more advantages than a single compound and a single biological preparation. The traditional Chinese medicines are natural products with small toxic and side effects, so that the medicinal composition is safer to take. The medicament has a good curative effect on osteoporosis.

The invention relates to a knee joint spreader. The knee joint spreader comprises a lower spreading plate, a guide rod, a gear rack structure, an upper spreading plate and a gear, wherein the guide rod is vertically arranged on the upper portion of the lower spreading plate, the gear rack structure is arranged on the guide rod and extends in the longitudinal direction of the guide rod, the upper spreading plate is arranged on the guide rod in a sleeving mode and is parallel to the lower spreading plate, the gear is arranged on the upper portion of the upper spreading plate through a support component, and the gear is rotatably arranged on the support component and can be meshed with the gear rack structure; when the gear rotates on the gear structure to force the upper spreading plate to slide upwards along the guide rod, the upper spreading plate gradually gets away from the lower spreading plate; when the gear rotates on the gear structure to force the upper spreading plate to slide downwards along the guide rod, the upper spreading plate gradually gets close to the lower spreading plate. By the adoption of the knee joint spreader, the gap between the femoral tibias can be spread in a parallel mode to reduce the possibility of bone defects of a patient caused by knee arthroplasty.

The invention relates to a composition capable of improving osteoporosis and increasing bone density. The composition comprises the following components in parts by weight of 10-30 parts of oligopeptide powder, 10-60 parts of saccharide substances, 10-60 parts of dietary fibers, 5-30 parts of maltodextrin, 5-15 parts of a calcium compound, and 0.1-2 parts of complex vitamins. When the compositionis eaten, the arthralgia can be notably reduced, the joint function can be improved, the hydroxyproline concentration in blood can be increased, the running off of sclerotin of post-menopause women suffering from osteoporosis is reduced, the treatment effect on anti-osteoporotic can be strengthened and prolonged, and the composition as a nutrient has the potential effect of preventing and treatingdegenerative arthritis and osteoporosis.

The invention relates to a tibia supporting assembly. The tibia supporting assembly comprises a tibia support and a supporting plate, wherein a first connecting surface and an implant surface which can be implanted into human tissue are formed on the tibia support; a second connecting surface and a supporting surface which can cooperate with a tibia liner are formed on the supporting plate, and the second connecting surface is connected with the first connecting surface. According to the embodiment, the tibia support and the supporting plate can be made of two different materials; the tibia support is made of a material with a better bone ingrowth effect and small stress shielding; the supporting plate is made of a wear-resistant material; frictional wear between the wear-resistant supporting plate and the tibia liner is small; the supporting plate has good wear resistance, and the service life is prolonged. On one hand, after the tibia support is implanted into the tibia, the ingrowthof the tibia to the tibia support is facilitated, and on the other hand, sliding friction between the supporting plate made of the wear-resistant material and the tibia liner is small, so that the advantage of biological fixation bone ingrowth can be brought into play on the whole, and abrasion of the prosthesis is effectively reduced.

The invention relates to application of a target mRNA of let-7f-5p for preparing medicine for treating osteoporosis, and belongs to the technical field of biologic medicine. Experiments verify that let-7f-5p mimics can reverse reduction of osteogenesis differentiation under GC induction; in-vivo experiments also verify that let-7f-5p tail intravenous injection can reduce loss of the GIOP mouse bone mass. Meanwhile, the let-7f-5p and a TGFBR1 gene have the target relationship, the let-7f-5p and the target gene thereof can be applied as a target for treating osteoporosis, a novel target is supplied by treatment adopting miRNA let-7f-5p and a target gene thereof as OP, and a novel therapeutic drug is supplied by treatment adopting miRNA let-7f-5p as OP.

The invention discloses an application of deferoxamine mesylate for injection in treating senile bone loss and bone marrow stem cell aging. It is shown in the invention that after deferoxamine mesylate is injected into an elderly rat, the phenomenon of bone aging (older bone loss) is reversed, and the aging of bone marrow stromal cells (stem cells) separated from a bone marrow cavity after medicine injection is relieved. It is further proved that intraperitoneal injection of a deferoxamine mesylate medicine can relieve bone mass loss related to rat age and recover aging phenotypes of rat bonemarrow stromal cells, such as promotion of cell growth (cell proliferation and colony formation), increase of osteogenesis, reduction of adipogenesis, reversion of the expression level of cell aging related markers, resistance to oxidative stress and the like.

This document provides methods and materials involved in reducing bone loss. For example, methods and material for using one or more inhibitors of a Rorβ polypeptide to reduce bone loss are provided. In some cases, methods and material for using one or more inhibitors of a Rorβ polypeptide to treat osteoporosis are provided.

The invention provides a flavonoid derivative for treating osteoporosis as well as a pharmaceutical composition and application thereof. The flavonoid derivative has a chemical structure shown as thefollowing formula A. The structural formula is as shown in the description. The product disclosed by the invention is the flavonoid derivative. The influence of estrogen on the reproductive system does not exist in the human body, but the activity of the estrogen can be increased, and the flavonoid derivative has the characteristic of estrogenic osteoporosis resistance and can achieve effects of reducing bone loss and increasing bone mineral density. The main anti-osteoporosis mechanisms are that (1) osteocyte proliferation can be promoted, bone collagen synthesis and mineralization of the bone matrix can be promoted, and the bone mass is increased; (2) proliferation and differentiation of osteoclast precursor cells can be reduced, the activity of the osteoclast is inhibited, and bone resorption is reduced; and (3) calcitonin secretion is increased by virtue of the estrogenic effect, and bone resorption resistance is indirectly produced.

The invention relates to a traditional Chinese medicine preparation for preventing osteoporosis and a preparation method for the traditional Chinese medicine preparation. The traditional Chinese medicine preparation for preventing the osteoporosis consists of the following main raw materials in parts by weight: 400-500 parts of herba epimedii, 300-400 parts of fructus psoraleae, 250-350 parts of Salvia miltiorrhiza, 200-300 parts of Astragalus mongholicus and 200-300 parts of zaocys dhumnade. The traditional Chinese medicine preparation capable of enhancing bone density is prepared through extracting, concentrating, drying, crushing and mixing the raw materials. Compared with traditional medicaments for preventing the osteoporosis, the traditional Chinese medicine preparation for preventing the osteoporosis is prepared from a pure traditional Chinese medicine prescription. The traditional Chinese medicine preparation for preventing the osteoporosis has an effect that the bone density is enhanced through adjusting internal secretion to promote the absorption of calcium. Moreover, the traditional Chinese medicine preparation for preventing the osteoporosis is stable and reliable in preparation process and is suitable for mass production.

The invention provides a personalized dental implant including a dental implant body and an abutment part; the abutment part is arranged on the dental implant body, and the abutment part is integrally formed with the dental implant body. The integrally-forming structure of the personalized dental implant can avoid the micro-leakage problem of a traditional two-section type connection, and a formed surface has no need of sandblasting treatment. A tooth root part of the personalized dental implant is prepared based on a true scan shape of a human tooth root, and can meet needs of different individuals on tooth roots during an implantation process; therefore, the personalized dental implant is more conducive to immediate implantation, reduces bone loss, reduces operation procedures, and makes an operation become a minimally invasive operation or even a non-invasive operation.