3results about How to "Reduce bone loss" patented technology

The invention discloses a micro-motion intramedullary nail, and relates to the field of medical instruments, the micro-motion intramedullary nail comprises an intramedullary nail main body, the intramedullary nail main body is composed of a far-end nail body and a near-end nail body, the far-end nail body is provided with a far-end interlocking screw hole, the near-end nail body is provided with a near-end interlocking screw hole, a micro-motion assembly is arranged between the far-end nail body and the near-end nail body, and the micro-motion assembly is connected with the near-end nail body. The micro-motion assembly comprises an absorbable block and a limiting nail body, and a femtosecond laser modified coating used for promoting fracture healing is arranged on the outer wall of the intramedullary nail body. According to the micro-motion intramedullary nail, by arranging the micro-motion assembly, the problem of stress shielding caused by the fact that an existing intramedullary nail is not matched with the elastic modulus of bone tissue is effectively solved, a proper micro-motion space is provided in the fracture healing period, the situation that the intramedullary nail excessively bears stress is avoided, the bone mass loss and osteoporosis risks are reduced, the secondary fracture probability is reduced, and the fracture healing period is shortened; meanwhile, the absorbable block does not need to be taken out through secondary operation, and pains and medical burdens of patients are relieved.

The invention belongs to the field of effects of traditional Chinese medicines in treatment of osteoporosis. The pathological change of osteoporosis is mainly bone microstructure injury, and comprises cortical bone thinning and porosity increase, bone trabecular connectivity loss, quantity reduction and gap increase, and bone reconstruction imbalance is the main reason of bone microstructure injury of osteoporosis patients. Adjustment of unbalanced bone metabolism and improvement of bone microstructure are key points in treatment. According to the technical scheme, the traditional Chinese medicine composition is preferably prepared from the following components in parts by weight: 1500 to 2500 parts of radix astragali seu hedysari, 300 to 600 parts of fructus schisandrae chinensis, 800 to 1200 parts of fructus lycii, 800 to 1200 parts of radix trichosanthis, 800 to 1200 parts of rhizoma anemarrhenae, 800 to 1200 parts of radix puerariae, 800 to 1200 parts of bulbus allii macrostemi, 500 to 700 parts of rhizoma acori graminei, 800 to 1200 parts of radix angelicae sinensis and 800 to 1200 parts of radix salviae miltiorrhizae. The traditional Chinese medicine composition disclosed by the invention can also be prepared into different dosage forms of medicines such as tablets, capsules, granules, oral liquid or injection together with pharmaceutically acceptable auxiliary materials.

This application discloses the application of Fe / Mn bimetallic enzymes in the preparation of anti-periodontalgia or teeth whitening agents. The Fe / Mn bimetallic enzyme exhibits excellent photothermal properties and peroxidase-like activity; that is, under photothermal synergy, its POD-like activity can be significantly enhanced, generating more ·OH groups. In antibacterial coating experiments against *Porphyromonas gingivalis* and drug-resistant *Staphylococcus aureus*, Fe / Mn BA, through photothermal synergistic chemokinetic therapy, achieved antibacterial rates exceeding 90%. By treating periodontitis through anti-inflammatory and antibacterial action and achieving teeth whitening through pigment degradation, the application of this biatomic nanozyme provides a new research direction for the application of artificial enzymes in oral diseases and is expected to open up broader pathways to address the challenges currently faced by artificial enzyme antibacterial technologies.